The effects of meloxicam, a non-steroidal anti-inflammatory drug on the biochemical parameters of rabbits

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Research Paper 01/08/2017
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The effects of meloxicam, a non-steroidal anti-inflammatory drug on the biochemical parameters of rabbits

Abrar Ahmad, Rehana Shah Nawaz, Saeed Ahmed Soomro, Naseem Rao, Muhammad Qasim
Int. J. Biosci.11( 2), 58-67, August 2017.
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Diclofenac been the predominant cause of vulture population decline in subcontinent has been mostly replaced by several NSAIDs. The present study was aimed to evaluate biochemical effect of meloxicam on functional status of liver and kidney of rabbit. Meloxicam was administered to rabbits divided into two treatment groups. The control group (A) was left untreated. Group B and C were given (1.5mg/kg b.w.) and (3.0mg/kg b.w.) meloxicam respectively for seven consecutive days. Blood samples were collected pre-treatment and on day 1, 3, 5 and 10 post-treatment for the assessment of Serum ALT (Alanine aminotransferase), AST (Aspartate aminotransferase), Bilirubin, ALP (Alkaline Phosphatase), Creatinine and Urea. All the parameters were evaluated from serum samples using Spectrophotometer. Obtained data were subjected to Student Edition of Statistics (SXW). Results showed a significant increase (P<0.05) in ALT, ALP, and Urea on day 1 post treatment with therapeutic dose, whereas with double dose these parameters showed a highly significant (P<0.01) increase on day 1, 3, 5 and significant (P<0.05) increase on day 10. The levels of serum AST, Bilirubin and Creatinine did not show marked elevation with therapeutic meloxicam and were found statistically non-significant (P>0.05). In contrast, double dose caused significant (P<0.01) increase in AST level upto last day. Creatinine showed significant (P<0.01) increase upto day 5 and significant (P<0.05) on day 10. Serum Bilirubin was significantly (P<0.01) increase upto day 3 and significant (P<0.05) only upto day 5 compared with control value. It was concluded that biochemical effects of Meloxicam are dose and time dependent.


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