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The immune modulatory effects of prolactin and cortisol in Hashimotos thyroiditis – A case control study

Research Paper | August 1, 2018

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Khayyam, Muhammad Zahid, Naiz Ali, Qadeem khan

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Int. J. Biosci.13( 2), 133-139, August 2018

DOI: http://dx.doi.org/10.12692/ijb/13.2.133-139


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The immune modulatory effect of serum prolactin (PRL) and cortisol were studied in Hashimoto’s thyroiditis (HT). The present case control study was conducted at the Department of Endocrinology, Institute of nuclear medicine and radiotherapy, Peshawar, Khyber-Pakhtunkhwa, Pakistan, from January 2017 to December 2017. Forty eight HT patients including (29 females) (34.97±1.454 years) and (19 males) (38.42±1.805 years) were selected. The thirty six control subjects included 21 females (31.43±1.698 years) and 15 males (37.93±2.561 years). HT females showed significantly higher (p = 0.0396) PRL values (631.8±119.7 mIU/L) than the control (322.7±44.84 mIU/L). Similarly HT males showed increased PRL values (p= 0.0215) (466.3±120.6 mIU/L) than control (134.4±19.59 mIU/L). In contrast, cortisol level was low in all HT patients (female= 101.9±20.37 ng/ml) and (male=106.8±21.77 ng/ml). Cortisol level in control females and males were (123±15.45 ng/ml.) and (163.9±23.25ng/ml) respectively. The TSH level was high in both males (16.24±1.135µIU/L) and females (5.793±1.395 µIU/L) patients while in control it was between the normal ranges (05-5µIU/L). The TT4 values in HT females (16.45±0.848 nmol/L) and males (6.956±2.667 nmol/L) were significantly lower than control. In conclusion, our results provide evidence for an altered prolactin-cortisol status in Hashimoto’s thyroiditis patients.


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The immune modulatory effects of prolactin and cortisol in Hashimotos thyroiditis – A case control study

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