The impact of cobalt chloride on enzyme activity of mice

Paper Details

Research Paper 01/08/2019
Views (1111)
current_issue_feature_image
publication_file

The impact of cobalt chloride on enzyme activity of mice

Khalid H. Gathwan, Khalil Ismail A. Mohamed, Mohammed Sami Kadhim
Int. J. Biosci. 15(2), 92-94, August 2019.
Copyright Statement: Copyright 2019; The Author(s).
License: CC BY-NC 4.0

Abstract

Liver is a primary site of toxic and plays important role metabolism, any changes in cobalt concentration in blood; this may affect the activities of antioxidant enzymes for adult male mice. (80) Days old, weighing 30- 35 gm., were treated orally COCl2 (15, 30, 45) mg / kg Body weight for 30 days. The acid phosphatase, alkaline phosphatase in the plasma and liver were estimated. There was a significant increasing in the activity of enzyme (p<0.05), these enzyme with moderate and high dose (30, 45) while no change with low dose (15). This investigation concluded that COCl2 caused increasing in the levels of enzyme with increase of dose.

Aquilian G, Bories G, Chesson A. 2012. Scientific opinion on safety and efficacy of cobalt carbonate as feed additive for ruminants, horses and rabbit. EFSA. Journal 10(6), 2727. https://doi.org/10.2903/j.efsa.2012.27.27

Bucher JR, Elwell MR, Thomoson MB. 1990. Inhalation toxicity studies of cobalt sulfate in F344/ N Rats and B6C3F1 mice, Toxicol Sci 15(2), 357-372.

Gathwan KH, Albir AA, Al-Saadi AH. 2013. Histological Changes in the Duodenum of Mice Treated with Cobalt, Iraqi Journal of Science 54(4), 1018-1022.

Gathwan KH, Al-Karkhi IHT, Yaseen AK. 2013. Organophosphorus Insecticides Induced Alterations in Liver of Male Albino Rat. Chemical Science Trans 2(S1), S95-S98.

Gathwan KH, Qasim M, Al Ameri A, Zaidan HK, Al Saadi AH. 2012. Heavy metals induced apoptosis in liver of mice International Journal Applied Biology and Pharmaceutical Techno 3(2), 146-150.

Guyton AC, Hall JE. 2006. Textbook of medical physiology, 9th Ed.10, Prism book (Pvt.) Ltd, Bangalore, India.

Hanafy MSM, Arbid MS, Afify MMH. 1991. Biochemical and histopathological effects of the organophosphorus insecticide (Tamaron) in rats. Indian Journal of Animal Science 61(1), 43-47.

Hayes RB. 1997. The carcnogenecity of metals in humans. Canc. Caus. Contr 8(3), 371-385.

Jordan C, Whitman RD, Harbut M, Tanner B. 1990. Memory deficits in workers suffering from hard metal disease. Toxcol. Let, 54(2-3), 241-243

King PR, King EJ. 1954. Estimation of plasma phosphatase by determination of hydrolysed phenol (with amino-antipyrine). Journal of Clinical Pathology 7, 322-326. http://dx.doi.org/10.1136/jcp.7.4.322

Korman EF, Ward JF, Myers LS. 1978. Development of Toxicology of Energy- Related Pollutants. D.O.E. Symposium Series 47, 384-395.

Maity S, Roy S, Chaudhury S, Bhattachar S. 2008. Antioxidant responses of the earthworm lampito mauriti exposed to p b and z n contaminated soil. Environmental Pollution 151(1), 1-7. https://doi.org/10.1016/j.envpol.2007.03.005

Related Articles

Characterization of juvenile growth of néré (Parkia biglobosa (Jacq.) R.Br. ex G. Don) in Northern Côte d’Ivoire

Koffi Adjoua Bénédicte*, Tra Bi Tra Jeannot, Sanogo Yacouba, Keita Abdoul Karim, Silue Pagadjovongo Adama, Soro Dramane, Int. J. Biosci. 29(4), 60-69, October 2026.

Ethnobotanical survey and pharmacological evaluation of aphrodisiac plants used in the department of Oumé (Central-West Côte d’Ivoire)

Moyabi Any Georges Armel*, Kpan Wokapeu Blaise, Tra Bi Zamblé Fidèle, Coulibaly Founzégué Amadou, Koné Mamidou Witabouna, Int. J. Biosci. 29(4), 38-47, October 2026.

When silence turns to pain: Decoding endodontic flare-ups

S. Vidya, T. Vinay Kumar Reddy*, K. Vijay Venkatesh, B. Shyam, Seetha Kunhikannan, Int. J. Biosci. 29(4), 23-37, October 2026.

Effect of rubber tree seed cake on the vegetative growth of oil palm in a nursery in La Mé, Southeast of Côte d’Ivoire

Adou Bini Yao Christophe*, Yoboue Ahou Natachat, Kelechi Nwanchor, Coulibaly koigni Junior Pacome, Konan Djézou, Kouakou Tanoh Hilaire, Int. J. Biosci. 29(4), 14-22, October 2026.

Diversity, botanical origin, and valorization potential of honeys from Lower Guinea, Guinea: A systematic descriptive review

Aude Eminsédé Kelomey*, Jean Loua, Steven Chokki, Ibrahima Kalil Sylla, Doumbouya Almamy Daouda, Elhadj Saidou Balde, Int. J. Biosci. 29(4), 1-13, October 2026.

Effects of crop succession on bird communities in an urban wetland in Korhogo (Côte d’Ivoire)

Konan Ekoun Michaël*, Niamien Coffi Jean Magloire, Guétondé Valérie Florence, Yéo N’gan-Nan, Yaokokoré-Béibro Kouassi Hilaire, Int. J. Biosci. 29(3), 94-107, September 2026.