Welcome to International Network for Natural Sciences | INNSpub

The polar fraction of a Sea cucumber (Bohadschia Argus) is a potential source of anti-inflammatory and hypoglycemic agents

Research Paper | June 1, 2022

| Download 28

Malihah I. Mamalo, Chona D. Gelani, Charlie A. Lavilla Jr.

Key Words:

Int. J. Biosci.20( 6), 254-260, June 2022

DOI: http://dx.doi.org/10.12692/ijb/20.6.254-260


IJB 2022 [Generate Certificate]


Diabetes is a complex metabolic condition that affects the glucose homeostasis of the human body. Inflammation has been significantly associated with diabetes pathogenesis and so makes this area a popular target for the prevention and treatment of these metabolic abnormalities. In this study, we have evaluated the anti-inflammatory and anti-diabetic properties of polar methanol (SB1M) and non-polar hexane (SB1H) extracts of a sea cucumber, B. argus, via inhibition of albumin denaturation assay, starch-iodine and glucose-uptake assay by yeast cells assays. Whilst there was no anti-inflammatory action observed in SB1H extracts, the SB1M showed anti-inflammatory potential (84.70±1.9% to 100±1.11%) with comparable activities with a known anti-inflammatory drug Flanax (Naproxen) (p<0.05). For anti-diabetic activity, the average alpha-amylase percent inhibition capacity for both extracts was observed to be in the range of 60.99±1.23% to 71.26±3.33% with a moderate enhancement of glucose uptake using yeast cells. Therefore, this study provides groundwork data to indicate B. argus as a potential source of agents with anti-inflammatory and anti-diabetic effects.


Copyright © 2022
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

The polar fraction of a Sea cucumber (Bohadschia Argus) is a potential source of anti-inflammatory and hypoglycemic agents

Abdulkhaleq LA, Assi MA, Abdullah R, Zamri-Saad M, Taufiq-Yap YH, Hezmee MNM. 2018. The crucial roles of inflammatory mediators in inflammation: A review. Veterinary World, 11(5), 627–635. https://doi.org/10.14202/vetworld.2018.627-635

Bellou V, Belbasis L, Tzoulaki I, Evangelou E. 2018. Risk factors for type 2 diabaetes mellitus: An exposure-wide umbrella review of meta-analyses. PloS one 13(3), e0194127. https://doi.org/10.1371/journal.pone.0194127

Celep, Gulcin Sagdicoglu Marotta F. 2005. Oxidants and Antioxidants in Health and Disease. Practical Approach to Respiratory Diseases 3(1), 285–285. https://doi.org/10.5005/jp/books/10638_35

Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Zhao L. 2018. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. https://doi.org/10.18632/oncotarget.23208

El Barky AR, Hussein SA, Alm-Eldeen AA, Hafez YA, Mohamed TM. 2016. Anti-diabetic activity of Holothuria thomasi saponin. Biomedicine & Pharmacotherapy 84, 1472–1487. https://doi.org/10.1016/j.biopha.2016.10.002

HPI, WJABN J. 2016. Phylum Echinodermata – A source for biologically active compounds: A Review. Phylum Echinodermata – A Source for Biologically Active Compounds: A Review 6(1).

Layson J, Criselda R, Rodil AM, Mojica EER, Deocaris C. 2014. Potential Anti-cancer and Anti-bacterial Activities of Philippine Echinoderm Extracts. Journal of Tropical Life Science 4(3), 175–175. https://doi.org/10.11594/jtls.04.03.03

Janakiram N, Mohammed A, Rao C. 2015. Sea Cucumbers Metabolites as Potent Anti-Cancer Agents. Marine Drugs 13(5), 2909–2923. https://doi.org/10.3390/md13052909

Khotimchenko Y. 2018. Pharmacological Potential of Sea Cucumbers. International journal of molecular sciences 19(5), 1342. https://doi.org/10.3390/ijms19051342

Kumar BA, Khan S, Saran GS, Nandeesh R, Manjunath NK. 2013. In vitro anti-diabetic activity of nisamalaki churna. Sains Malaysiana 42(5), 625-628.

Mathur S, Hoskins C. 2017. Drug development: Lessons from nature. Biomedical Reports 6(6), 612–614. https://doi.org/10.3892/br.2017.909

Mizushima Y, Kobayashi M. 1968. Interaction of anti‐inflammatory drugs with serum proteins, especially with some biologically active proteins. Journal of Pharmacy and Pharmacology 20(3), 169-173.

Oguntibeju OO. 2019. Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links. International Journal of Physiology, Pathophysiology and Pharmacology 11(3), 45-63.

Reshma Arun KP, Brindha P. 2014. In vitro anti-inflammatory, Antioxidant and nephroprotective studies on leaves of Aegle marmelos and Ocimum sanctum. Asian Journal of Pharmaceutical and Clinical Research 7(4), 122-129.

Shettar AK, Sateesh MK, Kaliwal BB, Vedamurthy AB. 2017. In vitro anti-diabetic activities and GC-MS phytochemical analysis of Ximenia americana extracts. South African Journal of Botany. https://doi.org/10.1016/j.sajb.2017.03.014

Stabili L, Acquaviva MI, Cavallo RA, Gerardi C, Narracci M, Pagliara P. 2018. Screening of Three Echinoderm Species as New Opportunity for Drug Discovery: Their Bioactivities and Antimicrobial Properties. Evidence-Based Complementary and Alternative Medicine. https://doi.org/10.1155/2018/7891748

Tsalamandris S, Antonopoulos AS, Oikonomou E, Papamikroulis G, Vogiatzi G. 2019. Risk Factors and Cardiovascular Disease Prevention The Role of Inflammation in Diabetes : Current Concepts and Future Perspectives. European Cardiology Review 14(1), 50–59.

Woodward JR, Cirillo VP. 1977. Amino acid transport and metabolism in nitrogen starved cells of Saccharomyces cerevisiae. Journal of Bacteriology. https://doi.org/10.1128/jb.130.2.714-723.1977

Xiao Z, Storms R, Tsang A. 2006. A quantitative starch-Iodine method for measuring alpha-amylase and glucoamylase activities. Analytical biochemistry 351(1), 146-148.