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The polar fraction of a Sea cucumber (Bohadschia Argus) is a potential source of anti-inflammatory and hypoglycemic agents

Malihah I. Mamalo, Chona D. Gelani, Charlie A. Lavilla Jr.

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Int. J. Biosci.20(6), 254-260, June 2022

DOI: http://dx.doi.org/10.12692/ijb/20.6.254-260

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Abstract

Diabetes is a complex metabolic condition that affects the glucose homeostasis of the human body. Inflammation has been significantly associated with diabetes pathogenesis and so makes this area a popular target for the prevention and treatment of these metabolic abnormalities. In this study, we have evaluated the anti-inflammatory and anti-diabetic properties of polar methanol (SB1M) and non-polar hexane (SB1H) extracts of a sea cucumber, B. argus, via inhibition of albumin denaturation assay, starch-iodine and glucose-uptake assay by yeast cells assays. Whilst there was no anti-inflammatory action observed in SB1H extracts, the SB1M showed anti-inflammatory potential (84.70±1.9% to 100±1.11%) with comparable activities with a known anti-inflammatory drug Flanax (Naproxen) (p<0.05). For anti-diabetic activity, the average alpha-amylase percent inhibition capacity for both extracts was observed to be in the range of 60.99±1.23% to 71.26±3.33% with a moderate enhancement of glucose uptake using yeast cells. Therefore, this study provides groundwork data to indicate B. argus as a potential source of agents with anti-inflammatory and anti-diabetic effects.

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The polar fraction of a Sea cucumber (Bohadschia Argus) is a potential source of anti-inflammatory and hypoglycemic agents

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