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Research Paper | August 1, 2013

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The responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron supplementation in healthy man

Mohammad Musaie, Mohammad Ali Azarbayjani, Maghsoud Peeri

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Int. J. Biosci.3(8), 319-324, August 2013

DOI: http://dx.doi.org/10.12692/ijb/3.8.319-324


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The purpose of present study was to investigate responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron and vitamin C supplementation in healthy man. For this purpose 21 subjects attended in this study, they were assigned randomly to three separate group: saffron group, vitamin C group and placebo group and during fourteen days, each group receive their supplement in form of capsule. After fourteen days supplementation subjects were running with their 70% of their VO2max on treadmill with 10 percent gradient for forty five minutes. Five ml Blood samples were taken from antecubital vein before supplementation, before exercise, immediately after exercise and 1h recovery after exercise. Data Analyzes of between group comparison using repeated measure ANOVA for CK and LDH in done. Results show significant decrease of CK immediately after exercise but LDH didn’t show significant changes by saffron supplementation. In general it seems that saffron supplementation during eccentric contraction activity decrease enzymatic activity of CK in comparison with control group.


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The responses of creatine kinase and lactate dehydrogenase to acute eccentric activity after saffron supplementation in healthy man

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