The role of Pet-Ct in neuroendocrine tumors without an identified primary focus: A case report and review

Paper Details

Case Study 04/08/2024
Views (518)
current_issue_feature_image
publication_file

The role of Pet-Ct in neuroendocrine tumors without an identified primary focus: A case report and review

Tinatin Rizaeva, Daniyar Shahanov, Shafee Ur Rehman, Kudaibergen Osmonaliev, Nurlan Mannapuulu, Meder Melisbekov, Damir Abibillaev
Int. J. Biosci. 25(2), 25-30, August 2024.
Copyright Statement: Copyright 2024; The Author(s).
License: CC BY-NC 4.0

Abstract

Neuroendocrine tumors are a rare group of heterogeneous tumors, mostly developed in the gastrointestinal and respiratory tract.  These tumors show overexpression of somatostatin receptors on the cell membrane, in which type 2 SSTRs are more common.  Functional imaging techniques are using for the NETs diagnosis and treatment. In this case a patient with neuroendocrine tumor (NET) without primary focus was admitted to the hospital due to recurrent episodes of cholecystitis. During diagnostic investigation incidentally anechoic foci in the patient’s liver were detected and pathological examination of this foci showed that it’s a metastasis of neuroendocrine tumor. The patient was previously investigated for the primary focus identification of NET, but no significant outcome was found. Hence, we used SSTR-based PET/CT scan 68Ga-DOTA-peptides, which showed the primary focus of NET in the tail of pancreas. Therefore, we concluded that the PET/CT scan 68Ga-DOTA-TATE showed significant outcome with identification of tumor localization.

Ambrosini V, Caplin M, Castaño JP, Christ E, Denecke T, Deroose CM, Dromain C, Falconi M, GrozinskyGlasberg S, Hicks RJ, Hofland J. 2024. Use and perceived utility of [18F] FDG PET/CT in neuroendocrine neoplasms: A consensus report from the European Neuroendocrine Tumor Society (ENETS) Advisory Board Meeting 2022. Journal of Neuroendocrinology 36(1), e13359.

Arrivi G, Specchia M, Pilozzi E, Rinzivillo M, Caruso D, Santangeli C, Prosperi D, Ascolese AM, Panzuto F, Mazzuca F. 2024. Diagnostic and Therapeutic Management of Primary Orbital Neuroendocrine Tumors (NETs): Systematic Literature Review and Clinical Case Presentation. Biomedicines 12(2), 379.

Di Franco M, Zanoni L, Fortunati E, Fanti S, Ambrosini V. 2024. Radionuclide Theranostics in Neuroendocrine Neoplasms: An Update. Current Oncology Reports 2024, 1-13.

Ditonno F, Franco A, Manfredi C, Veccia A, Valerio M, Bukavina L, Zukowski LB, Vourganti S, Stenzl A, Andriole GL, Antonelli A. 2024. Novel non-MRI imaging techniques for primary diagnosis of prostate cancer: micro-ultrasound, contrast-enhanced ultrasound, elastography, multiparametric ultrasound, and PSMA PET/CT. Prostate Cancer Prostatic Disease 27(1), 29-36.

Ghabra S, Ramamoorthy B, Andrews SG, Sadowski SM. 2024. Surgical Management and Long-Term Evaluation of Pancreatic Neuroendocrine Tumors. Surgical Clinics 104(4), 891-908.

Han S, Ryu J, Song SW, Kim JS, Ryu JS, Oh M. 2024. 68Ga-DOATATOC Brain PET/CT Imaging in a case of Dural Metastasis from Synovial Sarcoma. Nuclear Medicine and Molecular Imaging 2024, 1-7.

Has Simsek D, Guzel Y, Denizmen D, Sanli Y, Buyukkaya F, Kovan B, Komek H, Isik EG, Ozkan ZG, Kuyumcu S. 2024. The inferior performance of [68Ga] Ga-FAPI-04 PET/CT as a diagnostic and theranostic biomarker in [177Lu] Lu-DOTATATE refractory well-differentiated neuroendocrine tumors. European Journal of Nuclear Medicine and Molecular Imaging 51(3), 828-40.

Huang J, Liu H, Yang D, Xu T, Wang J, Li J. 2024. Personalized treatment of well-differentiated gastric neuroendocrine tumors based on clinicopathological classification and grading: A multicenter retrospective study. Chinese Medical Journal 2024, 10-1097.

Marcus C, Muzahir S, Subramaniam RM. 2024. Quarter Century PET/Computed Tomography Transformation of Oncology: Neuroendocrine Tumors. PET Clinics 19(2), 187-196.

Pishdad R, Treglia G, Mehta A, Santhanam P. 2024. Somatostatin receptor imaging of thyroid tissue and differentiated thyroid cancer using gallium-68-labeled radiotracers—a review of clinical studies. Endocrine 18, 1-10.

Raynor WY, Kempf JS. 2024. Somatostatin Receptor PET Imaging of Physiologic and Benign Processes: Implications for Image Interpretation, Avoiding Pitfalls, and Clinical Applications. Applied Radiology 2, 53.

Søreide K, Stättner S, Hallet J. 2024. Surgery as a Principle and Technical Consideration for Primary Tumor Resection of Small Bowel Neuroendocrine Tumors. Annals of Surgical Oncology 31(2), 1125-1137.

Sugawara H, Kikkawa N, Ito K, Watanabe H, Kaku S, Akai H, Abe O, Watanabe SI, Yatabe Y, Kusumoto M. 2024. Is 18F-fluorodeoxyglucose PET recommended for small lung nodules? CT findings of 18F-fluorodeoxyglucose non-avid lung cancer. British Journal of Radiology 97(1154), 462-468.

Wedin M, Janson ET, Wallin G, Sundin A, Daskalakis K. 2024. Prevalence of metastases outside the liver and abdominal lymph nodes on 68Ga‐DOTATOC‐PET/CT in patients with small intestinal and pancreatic neuroendocrine tumours. Journal of Neuroendocrinology 36(5), e13391.

Related Articles

Extraction of biologically active substances of fungi isolated from various ecosystems and evaluation of their effect

K. F. Bakhshaliyeva*, G. A. Tomuyeva, A. R. Hasanova, V. Y. Hasanova, A. M. Hasanov, S. E. Nagiyeva, A. G. Eyvazov, G. T. Huseynova, G. A. Qasimova, V. K. Isayeva, Int. J. Biosci. 28(2), 143-150, February 2026.

Integrative role of yeast culture metabolites in aquatic health and productivity

Sajjad Ur Rahman, Dur E Nayab, Rabia Kanwar*, Muhammad Mukarram Bashir, Int. J. Biosci. 28(2), 126-142, February 2026.

Land use efficiency and performance of sweet corn-cowpea intercropping influenced by temporal planting and methods of fertilizer application

Bryan Cristian M. Demolar, Marissa C. Hitalia*, Int. J. Biosci. 28(2), 101-125, February 2026.

Illuminating the deficiency: Public awareness of vitamin- D in Lahore, Pakistan

Muhammad Zeeshan Arif*, Muhammad Arslan Shahid, Zeerak Laila, Ahmad Ali Shabbir, Farrukh Nadeem, M Muazzam Khan, Yousuf Shahjahan, Rajab Ali, Int. J. Biosci. 28(2), 91-100, February 2026.

Characteristics of symbiotic relationships between plants and bacteria and the influence of stress factors on them

Konul F. Bakhshaliyeva, Navai D. İmamquliyev, Mehpara İ. Gasımova, Sevda M. Muradova, Panah Z. Muradov*, Int. J. Biosci. 28(2), 75-90, February 2026.

In the line of fire: Unmasking the institutional challenges in the bureau of fire protection

Mhelen Grace F. Libre, Nancy E. Aranjuez*, Int. J. Biosci. 28(2), 53-74, February 2026.

One health approch: Diversity of domestic larval habitats and human responsibility in mosquito proliferation in Bobo-Dioulasso (Burkina Faso)

Zouéra Laouali, Kouamé Wilfred Ulrich Kouadio, Moussa Namountougou*, Int. J. Biosci. 28(2), 38-52, February 2026.

Linkages between land use change, flooding, and water quality in the Pallikaranai Marshland, Chennai, India

Arunpandiyan Murugesan, Roshy Ann Mathews, Aarthi Mariappan, J. Ranjansri, Rajakumar Sundaram, Prashanthi Devi Marimuthu*, Int. J. Biosci. 28(2), 28-37, February 2026.