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Therapeutic effect of aerobic exercise training on serum resistin in asthma patients

Mokhtar Nasiri Farsani, Abbas Biniaz, Shahram Safari, Maryam Taghvayi

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J. Bio. Env. Sci.4(2), 148-153, February 2014


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Previous studies were reported higher adipokine resistin on asthma patients. The objective of this study was to estimate the effects of aerobic exercise program on serum resistin in asthma patients. For this purpose, twenty four adult men with chronic asthma aged 37 ± 6 were participated in this study and divided into exercise or control groups by randomly. Subjects in exercise group were completed an aerobic exercise program for three month, three times per week and control subjects was banned of exercise in this period. Pre and post training of anthropometrical markers and fasting serum resistin were measured in two groups. Exercise program resulted in significant decrease in serum resistin, body weight, BMI and body mass index in exercise group. All variables remained without change in control group. Based on this data, we can say aerobic training is associated with loss weight can be improve inflammation profile in asthma patients.


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Therapeutic effect of aerobic exercise training on serum resistin in asthma patients

Akshay S, Stephanie A. 2013. Adiponectin, Leptin, and Resistin in Asthma: Basic Mechanisms through Population Studies. Journal of Allergy 5, 1-15.

Arm JP, Lee TH. 1992. The pathobiology of bronchial asthma. Advances in Immunology 51, 323-382. http://dx.doi.org/10.1016/S0065-2776(08)60491-5

Arshi M, Cardinal J, Hill RJ, Davies PS, Wainwright C. 2010. Asthma and insulin resistance in children. Respirology     15, 779-784. http://dx.doi.org/10.1111/j.1440-1843.2010.01767.x

Ceddia MA, Voss EW, Woods JA. 2000. Intracellular mechanisms are responsible for the exhaustive exercise-induced suppression of macrophage antigen presentation. Journal of Applied Physiology 88, 804–810.

Fang  C,  Meng  O,  Wuetal  H.  2012.  Resistin-likemolecule-ß are a human airway remodeling mediator. European Respiratory Journal 39(2), 458–466. http://dx.doi.org/10.1183/09031936.00107811

Fantuzzi G. 2005. Adipose tissue, adipokines, and inflammation. Journal of Allergy and Clinical Immunology 115, 911-919. http://dx.doi.org/10.1016/j.jaci.2005.02.023

Jamaluddin MS, Weakley SM, Yao Q, Chen C. 2012. Resistin: functional roles and therapeutic considerations for cardiovascular disease, British Journal of Pharmacology 165(3), 622–632. http://dx.doi.org/10.1111/j.1476-5381.2011.01369.x

Jung SH, Park HS, Kim KS, Choi WH, Ahn CW, Kim BT. 2008. Effect of weight loss on some serum cytokines in human obesity: increase in IL-10 after weight loss. Journal of Nutritional Biochemistry 19(6), 371-5. http://dx.doi.org/10.1016/j.jnutbio.2007.05.007

Kaser S, Kaser A, Sandhofer A, Ebenbichler CF, Tilg H, Patsch JR. 2003. Resistin messenger-RNA expression is increased by proinflammatory cytokines in vitro. Biochemical and Biophysical Research Communications 309, 286-290. http://dx.doi.org/10.1016/j.bbrc.2003.07.003

Kelly AS, Steinberger J, Olson TP, Dengel DR. 2007. In the absence of weight loss, exercise training does not improve adipokines or oxidative stress in overweight children. Metabolism 56(7), 1005-9. http://dx.doi.org/10.1016/j.metabol.2007.03.009

Kim KW, Shin YH, Lee KE, Kim ES, Sohn MH, Kim KE. 2008. Relationship between adipokines and manifestations of childhood asthma. Pediatric Allergy and Immunology 19, 535-540. http://dx.doi.org/10.1111/j.1399-3038.2007.00690.x

Larochelle J, Freiler J, Dice J, Hagan L. 2007. Plasma resistin levels in asthmatics as a marker of disease state. Journal of Asthma 44, 509-513. http://dx.doi.org/10.1080/02770900701495785

Leivo-Korpela S, Lehtimäki L, Vuolteenaho K, Nieminen R, Kankaanranta H, Saarelainen S, Moilanen E. 2011. Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma. Journal of Inflammation (Lond) 8(12), 1-7.

Mayr SI, Zuberi RI, Liu FT. 2003. Role of immunoglobulin E and mast cells in murine models of asthma. Brazilian Journal of Medical and Biological Research 36(7), 821-7. http://dx.doi.org/10.1590/S0100-879X2003000700001

Nagel  G,  Koenig  W,  Rapp  K,  Wabitsch  M, Zoellner I, Weiland SK. 2008. Associations of adipokines with asthma, rhinoconjunctivitis, and eczema in German schoolchildren. Pediatric Allergy and Immunology [Epub ahead of print]

Pedersen BK, Hoffman-Goetz L. 2000. Exercise and the immune system: regulation, integration, and adaptation. Physiological Reviews 80, 1055–1081.

Rubin DA, McMurray RG, Harrell JS, Hackney AC, Thorpe DE, Haqq AM. 2008. The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise. Metabolism 57(5), 683-90. http://dx.doi.org/10.1016/j.metabol.2008.01.005

Sahoo RC, Acharya PR, Noushad TH, Anand R, Acharya VK, Sahu KR. 2009. A Study of High-Sensitivity C-Reactive Protein in Bronchial Asthma. Indian journal of chest diseases & allied sciences 51(4), 213-6.

Shanshan P, Yingying L. 2006. Role of Resistin in Inflammation and Inflammation-Related Diseases. Cellular & Molecular Immunology 3(1), 29-34.

Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN ET AL. 2008. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring) 16(5), 1033-8. http://dx.doi.org/10.1038/oby.2008.37

Silswal N, Singh AK, Aruna B, Mukhopadhyay S, Ghosh S, Ehtesham NZ. 2005. Human resistin stimulates the pro-inflammatory cytokines TNF-alpha and IL-12 in macrophages by NF-kappaB-dependent pathway. Biochemical and Biophysical Research Communications 334, 1092-1101. http://dx.doi.org/10.1016/j.bbrc.2005.06.202

Skilton MR, Celermajer DS. 2006. The effects of obesity-related peptides on the vasculature. Current Vascular Pharmacology 4(1), 79-85. http://dx.doi.org/10.2174/157016106775203135

Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. Journal of Huazhong University of Science and Technology. 25(2), 191-3, 201. http://dx.doi.org/10.1007/BF02873574

Woods JA, Lu Q, Ceddia MA, Lowder T. 2000. Exercise and neuroendocrine modulation of macrophage function. Immunology and Cell Biology 78, 545–553. http://dx.doi.org/10.1111/j.1440-1711.2000.t01-9-.x

Yokoyama A, Kohno N, Sakai K, Kondo K, Hirasawa Y, Hiwada K.1997. Circulating Levels of Soluble Interleukin-6 Receptor in Patients with Bronchial Asthma. American Journal of Respiratory and Critical Care Medicine 156(5), 1688-91. http://dx.doi.org/10.1164/ajrccm.156.5.9610070


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