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Three Cagayan Island endemic flora: Its phytochemicals and hypoglycemic effect on alloxan induced Sprague Dawley Rat

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Research Paper 03/07/2023
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Three Cagayan Island endemic flora: Its phytochemicals and hypoglycemic effect on alloxan induced Sprague Dawley Rat

Jane R. Sambrana, Andy L. Catulin
J. Bio. Env. Sci.23( 1), 7-12, July 2023.
Certificate: JBES 2023 [Generate Certificate]
Key: AlloxanEndemicHealth scienceHypoglycemicPhilippinesPhytochemicalsSprague Dawley Rats

Abstract

Cagayan province is blessed with vast flora with presence of many island species that are endemic. Currently, different botanicals have been formulated as pharmaceutical agents to developed new products essential for human wellbeing. This study generally aimed to determine the secondary metabolites present in the three island endemic plant species in Cagayan namely; Igem dagat (Podocarpus costalis C. Presl), Balingagta (Drypetes falcata Pax & K. Hoffm.) and Babuyan lunas (Lunasia babuyanica Merr.) and to determine their hypoglycemic effect on Sprague Dawley Rats. Ethanolic leave extract of the three endemic plant species were used and tested for its phytochemicals. Complete randomized design (CRD) was used for the hypoglycemic potential with three replications for each species and Alloxan was used to induce hyperglycemia in the rats. The results reveals that P. costalis, D. falcata and L. babuyanica contains alkaloids, flavonoids, glycosides, tannins and tripertenes. Likewise, L. babuyanica and D. falcata were also positive with saponin and phytosterols. Analysis of variance (ANOVA) for the initial glucose level, after Alloxan induced and after treatment of plant extracts did not show significant difference across treatment means. Among the treatments, T3 (L. babuyanica ethanolic leave extract) significantly reduced the Alloxan induced hyperglycemia in Spraue Dawley Rats. Glucose level were reduced with the administration of the other treatments but not significant to reject the null hypothesis. All the plant extracts have hypoglycemic effect however, T3 (L. babuyanica ethanolic leave extract) is more effective.

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Boon NA, Colledge NR, Walker BR. 2006. Diabetes mellitus. In vidson’s Principles and Practice of Medicine (ed. Hunter, J.A.A.), Elsevier, Edinburg, pp 805-847. Boyle J.P., Honeycutt A.A., Narayan K.M., www.academia.edu/Diabetes_mellitus_The_P

Carlson, Elizabeth A. 1998. Prospective Longitudinal Study of Attachment Disorganization/ Disorientation Child Development 69(4), pages 1107-1128.

Dhasarathan P, Theriappan P. 2011. Evaluation of anti-diabetic activity of Strychonous potatorum in alloxan induced diabetic rats- J Med Med Sci.

Krishnaraju V, Manimekalai P, Davidraj C. 2010. “Effect of Hydro Alcoholic Extract of Nelumbo nucifera (G) on STZ induced Diabetic Rats.” International Journal of Pharma World Research June-Sept.

Lancion Jr, Conrado M, de Guzman, Rey (cartography). 1995. “The Provinces”. Fast Facts about Philippine Provinces (The 2000 Millenium ed.). Makati, Metro Manila: Tahanan Books pp. 48, 49, 84, 118. ISBN 971-630-037-9.

Rajalakshmi M, Cecilia Edel Priya, Nirmala A, Daisy P. 2009. Anti-diabetic properties of Tinospora cordifolia stem extracts on streptozotocin- induced diabetic rats. Academic Journal Organization. 28 Apr.

Trivedi NA, Mazumder B, Bhatt JD, Hemavathi KG. 2004. Effect of Shilajit on blood glucose and lipid profile in alloxan induced diabetic rats. Indian J. Pharmacol 36, 373-376.

WHO. 1991. World Health Organization Department of Noncommunicable Disease Serveillance.

World Health Organization IDF. 2004. Diabetes Action Now: An initiative of WHO and IDF.

Yadav Manish, Khalid Kafeel Khan, Beg MZ. 2012. Medicinal Plants Used for the Treatment of Diabetes by the Baiga Tribe Living in Rewa District m.p. Indian Journal Science 2(1), 99-102, http://www.ijls.in/upload/897053355PAPER_19.

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