Thrombolytic and allelopathic activities of medicinal plant: Strobilanthes urticifolia Wall. Ex Kuntze.
Paper Details
Thrombolytic and allelopathic activities of medicinal plant: Strobilanthes urticifolia Wall. Ex Kuntze.
Abstract
Indigenous knowledge and literature review reveals that there is no such information or citation is available on proposed study and was aimed to evaluate the crude methanolic extract (CME)and different fractions of Strobilanthes urticifolia Wall. ex Kuntze for thrombolytic and allelopathic activities. CME and different fractions were tested against clot lytic activity in the thrombolytic test and the result showed that crude methanolic extract (56.11%) and chloroform fraction (64.94%) havehighest thrombolytic activity followed by n-hexane fraction (29.66%) while effect of ethyl acetate fraction (7.58%) and aqueous fraction (9.88%) on the blood clots ware almost negligible as compared to positive controlstreptokinase (SK) and negative control water which showed 76.44% and 5.97 % lysis of clot respectively. Only aqueous fraction was checked for the presence of allelochemicals in allelopathic activity and the result showed that at low concentration (25 and 50 %) the germination was 70±3.50% and 60±2.00% respectively while at high concentration of aqueous fraction it was reduce to 40±3.50 as compared to negative control water. Moisture content, shoot and radical length of the wheat seed in allelopathic activity was also noted and it also reduced in dose-dependent (25, 50 and 100 %) manner.These results suggest that CME and different fractions of Strobilanthes urticifoliaWall.exKuntze has significant thrombolytic and allelopathic properties and needs further exploration.
Ali MR, Hossain M, Runa JF, Hasanuzzaman M, Islam MM. 2014. Evaluation of thrombolytic potential of three medicinal plants available in Bangladesh, as a potent source of thrombolytic compounds. Avicenna Journal of Phytomedicine 4(6), 430–436.
Ansaria P, Uddina MJ, Rahman MM, Abdullah-Al-Mamun M, Islam MR, Ali MH and Ali Reza ASM. 2016. Anti-inflammatory, anti-diarrheal, thrombolytic and cytotoxic activities of an ornamental medicinal plant: Persicaria orientalis. Journal of Basic and Clinical Physiology and Pharmacology 28(1), 51-58. https://doi.org/10.1515/jbcpp-2016-0023
Asaduzzaman M, Luckett DJ, Cowley RB, An M, Pratley JE, Lemerle D. 2014. Canola cultivar performance in weed-infested field plots confirms allelopathy ranking from in vitro testing. Biocontrol Science and Technology 24(12), 1394-1411. http://dx.doi.org/10.1080/09583157.2014.942596
Cantrell CL, Dayan FE, Duke SO. 2012. Natural products as sources for new pesticides. Journal of Natural Product 75(6), 1231-1242. https://doi.org/10.1021/np300024u
Hien LT, Park S, Park YJ, Won OJ, Hwang JB, Park SU, Park KW. 2015. Allelopathy in Sorghum bicolor (L.) moench: A review on environmentally friendly solution for weed control. Research on Crops 16(4), 657-662.
Kabir MSH, Murad MAH, Hasanat A, Hamid MA, Islam MI, Chowdhury TA, Hasan M, Hossain MM, Masum MAA, Uddin MR. 2015. Evaluation of total flavonols, total proanthocyanidins content and thrombolytic activity of methanol extracts of three Bangladeshi plants. International Journal of Pharmacy 5(3), 747-751.
Khang D, Anh L, Ha T, Tuyen PT, Quan N, Minh L, Quan NT, Minh TN, Xuan TD, Khanh TD. 2016. Allelopathic activity of dehulled rice and its allelochemicals on weed germination. International Letters of Natural Sciences 58, 1-10 https://dx.doi.org/10.18052/www.scipress.com/ILNS.58.1
Laurence DR, Bennett PN. 1992. Clinical Pharmacology. Churchill Livingstone, seventh edition, New York, p. 483.
Naderi GA, Asgary S, Jafarian A, Askari N, Behagh A, Aghdam RH. 2005. Fibrinolytic effects of Ginkgo biloba extract. Experimental and Clinical Cardiology 10(2), 85-7.
Prasad S, Kashyap RS, Deopujari JY. 2007. Effect of Fagonia arabica (Dhamasa) on in vitro thrombolysis. BMC Complementary and Alternative Medicine 7, 36. https://dx.doi.org/10.1186%2F1472-6882-7-36
Prasad S, Kashyap RS, Deopujari JY, Purohit HJ, Taori GM, Daginawala HF. 2006. Development of an in vitro model to study clot lysis activity of thrombolytic drugs. Thrombosis Journal 4, 14. https://doi.org/10.1186/1477-9560-4-14
Putnam AR, Tang CS. 1988. The Science of Allelopathy. Ecology 69(1), 292–293. https://doi.org/10.2307/1943186
Rahman MA, Sultana R, Emran TB, Islam MS, Rahman MA, Chakma JS, Rashid H, Hasan CMM. 2013. Effects of organic extracts of six Bangladeshi plants on in vitro thrombolysis and cytotoxicity. BMC Complementary and Alternative Medicine 13, 25. https://doi.org/10.1186/1472-6882-13-25
Rawat LS, MaikhuriRK ,Vikram S. Negi, Yateesh M. Bahuguna ,Dalbeer S. Pharswan , Maletha A. 2016. Allelopathic Performance of Medicinal Plants on Traditional Oilseed and Pulse Crop of Central Himalaya, India. Natl. Acad. Sci. Lett 39(3), 141–144. https://doi.org/10.1007/s40009-016-0435-3
Zaman R, Parvez M, Jakaria M, Sayeed MA, Islam M. 2015. In vitro Clot Lysis Activity of Different Extracts of Mangifera sylvatica Roxb. Leaves. Research Journal of Medicinal Plant 9(3), 135-140. https://doi.org/10.3923/rjmp.2015.135.140
Arshad Farid, Bashir Ahmad, Kashif Bashir, Yaqoob ur Rehman, Shafiullah Khan, 2017. Thrombolytic and allelopathic activities of medicinal plant: Strobilanthes urticifolia Wall. Ex Kuntze.. Int. J. Biosci., 11(6), 39-44.
Copyright © 2017 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.