Toxicity of silver nanoparticles in fish: a critical review

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Toxicity of silver nanoparticles in fish: a critical review

Muhammad Saleem Khan, Farhat Jabeen, Naureen Aziz Qureshi, Muhammad Saleem Asghar, Muhammad Shakeel, Aasma Noureen
J. Bio. Env. Sci.6( 5), 211-227, May 2015.
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Abstract

The variable spectrum of applications largely depends upon silver physicochemical and biological properties which changes as the particles are decreased to nano-scale. This unique behavior is responsible for the larger use of silver in consumer product and industry. Since little information is available about toxicity to the organisms practically in the aquatic environment, the predication of possible environmental hazards and remedy are the hot topics of current research studies. Researchers are drawing more and more data from appropriate model organisms. Fish being aquatic organism is badly affected by Ag-NPs, so concern of potential risk to aquatic organism increases. The toxicity endpoints include growth and reproduction impairment, mortality and biochemical changes in both adult fish and embryos. Being a healthy food for human, the researchers try to know how Ag-NPs can affect the fish and its body when sizes decrease to nano-scale. Therefore, fish is extensively studied model in the toxicological studies. It examined some of these studies which address the adverse effects of Ag-NPs on biological systems of different fish group predicting the dose dependent toxicity. The organisms more acutely sensitive have lower LC50 values. All the studies also indicated that silver ions released from Ag-NPs surface contributes to toxicity. Therefore, it is suggested that emphasis should be placed on upcoming investigations for the evaluation of environmental impact of nano-silver in both in vitro and in vivo studies. The effect of long term exposure and bioaccumulation of silver through food web should be unmasked and discussed in detail.

VIEWS 10

Alt V, Bechert T, Steinrucke P, Wagener M, Seidel P, Dingeldein E, Domann E, Schnettler R. 2004. An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement. Biomaterials 25(18), 4383-4391. doi:10.1016/j.biomaterials.2003.10.078

Alt V, Wagener M, Salz D, Bechert T, Steinrucke P, Schnettler R. 2006. Plasma polymer high-porosity silver composite coating for infection prophylaxis in intramedullary nailing. Practice of Intramedullary Locked Nails pp. 297-303. DOI: 10.1007/3-540-32345-7_30

Ananth AN, Daniel SCG, Sironmani TA, Umapathi. 2011. PVA and BSA stabilized silver nanoparticles based surface–enhanced plasmon resonance probes for protein detection Colloids and Surfaces B: Biointerfaces 85(2), 138-144. doi:10.1016/ j.colsurfb.2011.02.012

Arora S, Jain J, Rajwade JM, Paknikar KM. 2009. Interactions of silver nanoparticles with primary mouse fibroblasts and liver cells. Toxicology and Applied Pharmacology 236(3), 310–318. doi:10.1016/j.taap.2009.02.020.

Asharani PV, Wu YL, Gong Z, Valiyaveetti S. 2008. Toxicity of silver nanoparticles in zebrafish models. Nanotechnology 19(25), 55-102. -doi:10.1088/0957-4484/19/25/ 255102

Aslan K, Geddes CD. 2006. Microwave-accelerated and metalenhanced fluorescence myoglobin detection on silvered surfaces: Potential application to myo-cardial infarction diagnosis. Plasmonics 1(1), 53-59. DOI: 10.1007/s11468-006-9006-7

Aslan K, Huang J, Wilson GM, Geddes CD. 2006. Metalenhanced fluorescence-based RNA sensing. Journal of American Chemical Society 128, 4206-4207.

ATSDR (Agency for Toxic Substances and Disease Registry). 1990. Toxicological profile for Silver. Prepared by Clement international corporation, under Contract 205-88-0608). U.S. public Health Service. ATSDR/TP-90-24.

Bar-Ilan O, Albrecht RM, Fako VE, Furgeson DY. 2009. Toxicity assessments of multisized gold and silver nanoparticles in Zebrafish embryos. Small 5(16), 1897-910. DOI: 10.1002/smll.200801716.

Bayston R, Ashraf W, Fisher L. 2007. Prevention of infection in neurosurgery: Role of ‘antimicrobial’ catheters. Journal of Hospital Infection 65(2), 39-42. DOI: http://dx.doi.org/10.1016/S0195-6701(07)60013-9.

Benn TM, Westerhoff P. 2008. Nanoparticle silver released into water from commercially available sock fabrics. Environmental Science and Technology 42(11), 4133–4139. DOI: 10.1021/es7032718.

Bhol KC, Alroy J, Schechter PJ. 2004. Anti-inflammatory effect of topical nanocrystalline silver cream on allergic contact dermatitis in a guinea pig model. Clinical Experimental Dermatology 29(3), 282-287. DOI: 10.1111/j.1365-2230.2004.01515.x.

Bhol KC, Schechter PJ. 2007. Effects of nanocrystalline silver (NPI 32101) in a rat model of ulcerative colitis. Digestive Diseases and Sciences 52, 2732-2742. DOI: 10.1007/s10620-006-9738-4.

Bilberg K, Doving KB, Beedholm K, Baatrup E. 2011. Silver nanoparticles disrupt olfaction in Crucian carp (Carassius carassius) and Eurasian perch (Perca fluviatilis). Aquatic Toxicology 104, 145–152. doi: 10.1016/j.aquatox.2011. 04.010.

Blaser SA, Scheringer M, MacLeod M, Hungerbühler K. 2008. Estimation of cumulative aquatic exposure and risk due to silver: Contribution of nano-functionalized plastics and textiles. Science of Total Environment 390 (2-3), 396–409. DOI: 10.1016/ j.scitotenv. 2007.10.010.

Bouadma L, Wolff M, Lucet JC. 2012. Ventilator-associated pneumonia and its prevention. Current opinion in infectious diseases 25 (4), 395–404. doi: 10.1097/ QCO.0b013e328355a835.

Braydich-Stolle L, Hussain S, Schlager JJ, Hofmann MC. 2005. In vitro cytotoxicity of nanoparticles in mammalian germline stem cells. Toxicological Science 88(2), 412–419. doi: 10.1093/toxsci/kfi340.

Carlson C, Hussain S, Schrand A, Braydich-Stolle L, Hess K, Jones R, Schlager J. 2008. Unique cellular interaction of silver nanoparticles: Size-dependent generation of reactive oxygen species. The Journal of Physical Chemistry 112(43), 13608-13619. DOI: 10.1021/jp712087m.

Catsakis LH, Sulica VI. 1978. Allergy to silver amalgams. Oral Surgery Medicine Oral Pathology Oral Radiology 46(3), 371-375. DOI: http://dx.doi.org/ 10.1016/0030-4220(78)90402-4.

Chae YJ, Pham CH, Lee J, Bae E, Yi J, Gu MB. 2009. Evaluation of the toxic impact of silver nanoparticles on Japanese medaka (Oryzias latipes). Aquatic Toxicology 94(4), 320–327. doi:10.1016/j.aquatox.2009.07.019

Chen LQ, Fang L, Ling J, Ding CZ, Kang B, Huang CZ. 2015. Nanotoxicity of silver nanoparticles to red blood cells: size dependent adsorption, uptake, and hemolytic activity. Chemical Research in Toxicology 28(3), 501-9. doi: 10.1021/tx 500479m.

Chen W, Liu Y, Courtney HS, Bettenga M, Agrawal CM, Bumgardner JD, Ong JL. 2006. In vitro anti-bacterial and biological properties of magnetron co-sputtered silver-containing hydroxyapatite coating. Biomaterials 27(32), 5512-5517. doi:10.1016/j.biomaterials.2006.07.003.

Chen X, Schluesener HJ. 2008.  Nanosilver:  A nanoproduct in medical application. Toxicological Letters 176(1), 1–12. doi:10.1016/j.toxlet.2007.10.004.

Cho JG, Kim KT, Ryu TK, Lee JW, Kim JE, Kim J, Lee BC, Jo EH, Yoon J, Eom IC, Choi K, Kim P. 2013. Stepwise Embryonic Toxicity of Silver Nanoparticles on Oryzias latipes. BioMed Research International, Article ID 494671, 7 pages. http:// dx. doi.org/10.1155/2013/494671.

Choi JE, Kim S, Ahn JH, Youn P, Kang JS, Park K, Yi J, Ryu D. 2009. Induction of oxidative stress and apoptosis by silver nanoparticles in the liver of adult Zebrafish. Aquatic Toxicology 100(2), 151-159. doi: 10.1016/j.aquatox. 2009.12.012.

Coelho S, Amarelo M, Ryan S, Reddy M, Sibbald RG. 2004. Rheumatoid arthritis-associated inflammatory leg ulcers: A new treatment for recalcitrant wounds. International Wound Journal 1(1), 81-84. DOI: 10.1111/j.1742-481x.2004. 0002.x.

Cohen MS, Stern JM, Vanni AJ, Kelley RS, Baumgart E, Field D, Libertino JA, Summer-hayes IC. 2007. In vitro analysis of a nanocrystalline silver-coated surgical mesh. Surgical Infections (Larchmt.) 8(3), 397-403. DOI: 10.1089/sur.2006.032

Deery C. 2009. Silver lining for caries cloud? Evidence-Based Dentistry 10(3), 68. doi:10.1038/ sj. ebd.6400661

Diehl AM. 2000. Cytokine regulation of liver injury and repair. Immunological Reviews 174(1), 160-171. DOI: 10.1034/j.1600-0528.2002.017411.x

Dowling A, Clift R, Grobert N, Hutton D, Oliver R, Neill O, Pethica J, Inoue KI, Takano H, Yanagisawa R, Koike E, Shimada A. 2009. Size effects of latex nanomaterials on lung inflammation in mice. Toxicology and Applied Pharmacology 234(1), 68-76. doi:10.1016/j.taap.2008.09.012

Drake PL, Hazelwood KJ. 2005. Exposure-related health effects of silver and silver compounds: A review. The Annals of Occupational Hygiene 49(7), 575-585. doi: 10.1093/annhyg/mei019

EC. 1999. Annex VI of Directive 1999/45/EC to consolidated version of directive 67/548/EEC. General classification and labeling requirements for dangerous substances and preparations. ec.europa.eu/environment/archives/dansub/pdfs/an nex6_ en.pdf

EC. 2008. Regulation (EC) No 1272/2008 of the European Parliament and Council of 16 December 2008 on classification, labeling and packaging of substances and mixtures, Official Journal of the European Union, 31.12.2008. http://eur-lex.europa.eu/legal-content/en/TXT/?uri =CELEX:32008R1272.

Elechiguerra JL, Morones JR, Camacho A, Holt K, Kouri JB, Ramirez JT, Yacaman MJ. 2005. Interaction of silver nanoparticles with HIV-1. Journal of Nanotechnology 16, 23-46. DOI: 10.1186/1477-3155-3-6

Farkas J, Christian P, Gallego JA, Urrea N, Roos, Hassellöv M, Tollefsen KE, Thomas KV. 2010. Effects of silver and gold nanoparticles on rainbow trout (Oncorhynchus mykiss) hepatocytes. Aquatic Toxicology 96(1), 44-52. doi:10.1016/j. aquatox.2009.09. 016

Gliga AR, Skoglund S, Wallinder IO, Fadeel B, Karlsson HL. 2014. Size-dependent cytotoxicity of silver nanoparticles in human lung cells: the role of cellular uptake, agglomeration and Ag release. Particle and Fibre Toxicology 11(11), 1-17 doi: 10.1186/1743-8977-11-11

Gonzalez P, Baudrimont M, Boudou A, Bourdineaud JP. 2006. Comparative effects of direct cadmium contamination on gene expression in gills, liver, skeletal muscles and brain of the zebrafish (Danio rerio). Biometals 19(3), 225–235. DOI: 10.1007/s10534-005-5670-x.

Griffitt RJ, Hyndman K, Denslow ND, Barber DS. 2009. Comparison of molecular and histological changes in zebrafish gills exposed to metallic nanoparticles. Toxicological Science 107(2), 404-415. doi: 10.1093/toxsci/kfn256

Griffitt RJ, Luo J, Gao J, Bonzongo JC, Barber DS. 2008. Effects of particle composition and species on toxicity of metallic nanomaterials in aquatic organisms. Environmental Toxicology and Chemistry 27(9), 1972–1978. DOI: 10.1897/08-002.1

Gulbranson SH, Hud JA, Hansen RC. 2000. Argyria following the use of dietary supplements containing colloidal silver protein. Cutis 66, 373-376.

Handy RH, Owen R, Valsami-Jones E. 2008. The ecotoxicology of nanoparticles and nanomaterials: current status, knowledge gaps, challenges, and future needs. Ecotoxicology 17(5), 315-325. doi: 10.1007/s10646-008-0206-0.

Hawkins AD, Thornton C, Kennedy AJ, Bu K, Cizdziel J, Jones BW, Steevens JA, Willett KL. 2015. Gill histopathologies following exposure to nanosilver or silver nitrate. Journal of Toxicology and Environmental Health A 78(5), 301-15. doi: 10.1080/15287394.2014.971386.

He J, Lin L, Liu H, Zhang P, Lee M, Sankey OF, Lindsay SM. 2009. A hydrogen-bounded electron-tunneling circuit reads the base composition of unmodified DNA. Nanotechnology 20(7), 075102. doi: 10.1088/0957-4484/20/7/075102

Hedayati A, Kolangi H, Jahanbakhshi A, Shaluei F. 2012a. Evaluation of Silver nanoparticles Ecotoxicity in Silver carp (Hypophthalmicthys molitrix) and Goldfish (Carassius auratus). Bulgarian Journal of Veterinary Medicine 15(3), 172−177. Article id: 80158939

Hedayati A, Shaluei F, Jahanbakhshi A. 2012b. Comparison of Toxicity Responses by Water Exposure to Silver Nanoparticles and Silver Salt in Common Carp (Cyprinus carpio). Global Veterinaria 8(2), 179-184.

Hussain SM, Hess KL, Gearhart JM, Geiss KT, Schlager JJ. 2005. In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicology in Vitro 19(7), 975–983. doi:10.1016/j.tiv.2005.06.034.

Inoue Y, Uota M, Torikai T, Watari T, Noda I, Hotokebuchi T. 2010. Antibacterial properties of nanostructured silver titanate thin films formed on a titanium plate. Journal of Biomedical Materials Research Part A 92A(3), 1171-1180. doi: 10.1002/jbm.a.32456.

Ivask A, Kurvet I, Kasemets K, Blinova I, Aruoja V. 2014. Size-Dependent Toxicity of Silver Nanoparticles to Bacteria, Yeast, Algae, Crustaceans and Mammalian Cells In Vitro. PLoS ONE 9(7), e102108. doi:10.1371/journal.pone.0102108

Jahanbakhshi A, Shaluei F, Hedayati A. 2012b. Detection of Silver Nanoparticles (Nanosil®) LC50 in Silver Carp (Hypophthalmichthys molitrix) and Goldfish (Carassius auratus). World Journal of Zoology 7(2), 126-130. DOI: 10.5829/idosi. wjz.2012.7.2.62129.

Jang MH, Kim WK, Lee SK, Henry TB, Park JW. 2014. Uptake, tissue distribution, and depuration of total silver in common carp (Cyprinus carpio) after aqueous exposure to silver nanoparticles. Environmental Science and Technology 48(19), 11568-74. doi: 10.1021/es5022813.

Johari SA,  Kalbassi MR, Soltani  M,  Yu IJ. 2013. Toxicity comparison of colloidal silver nanoparticles in various life stages of rainbow trout (Oncorhynchus mykiss). Iranian Journal of Fisheries Science 12(1), 76 -95.

Jones CM, Hoek EM. 2010. A review of the antibacterial effects of silver nanomaterials and potential implications for human health and the environment. Journal of Nanoparticle Research 12, 1531–1551.

Jovanovic B, Anastasova L, Rowe EW, Zhang Y, Clapp AR, Palic D. 2011. Effects of nanosized titanium dioxide on innate immune system of fathead minnow (Pimephales promelas Rafinesque, 1820). Ecotoxicology and Environmental Safety 74(7), 675-683. DOI: 10.1016/j.ecoenv.2010.10.017

Jung WK, Kim SH, Koo HC, Shin S, Kim JM, Park YK, Hwang SY, Yang H, Park YH. 2007. Antifungal activity of the silver ion against contaminated fabric. Mycoses 50(4), 265–269. DOI: 10.1111/j.1439-0507.2007.01372.x

Kalbassi MR, Johari SA, Soltani M, Yu LJ. 2013. Particle Size and Agglomeration Affect the Toxicity Levels of Silver Nanoparticle Types in Aquatic Environment. ECOPERSIA 1(3), 273-290.

Kannan R, Jerley A, Ranjani M, Prakash V. 2011. Antimicrobial silver nanoparticle induces organ deformities in the developing Zebra fish (Danio rerio) embryos. Journal of Biomedical Science and Engineering 4, 248-254. doi: 10.4236/ jbise.2011.44034.

Katuli KK, Massarsky A Hadadi A, Pourmehran Z. 2014. Silver nanoparticles inhibit the gill Na⁺/K⁺-ATPase and erythrocyte AChE activities and induce the stress response in adult zebrafish (Danio rerio). Ecotoxicology and Environmental Safety 106, 173-80 doi: 10.1016/j.ecoenv.2014.04.001.

Kim J, Kuk E, Yu K, Park S, Lee H, Kim S, Park Y, Hwang C, Kim Y, Lee Y, Jeong D, Cho M. 2007. Antimicrobial effects of silver nanoparticles. Nanomedicine: Nanotechnology, Biology and Medicine 3(1), 95-101. doi:10.1016/j.nano. 2006.12.001

Kim J, Lee J, Kwon S, Jeong S. 2009. Preparation of biodegradable polymer/silver nano-particles composite and its antibacterial efficacy. Journal of Nanoscience and Nanotechnology 9(2), 1098–1102. doi:10.1166/jnn.2009.C096

Kim  JY, Kim  KT, Lee  BG, Lim  BJ, Kim  SD. 2013. Developmental toxicity of Japanese medaka embryos by silver nanoparticles and released ions in the presence of humic acid. Ecotoxicology and Environmental Safety 92(1), 57-63. doi: 10.1016/j. ecoenv.2013.02.004.

Kirsner RS, Orstead H, Wright JB. 2001. Matrix metalloproteinases in normal and impaired wound healing: a potential role for nanocrystalline silver. Wounds 13(3), 5-12.

Klaprat DA, Evans RE, Hara TJ. 1992. Environmental contaminants and chemoreception in fishes. In Fish Chemoreception Fish and Fisheries Series 6, 321-341. DOI: 10.1007/978-94-011-2332-7_15.

Kumar PS, Sivakumar R, Anandan S, Madhavan J, Maruthamuthu P, Ashokkumar M. 2008. Photocatalytic degradation of Acid Red 88 using Au TiO2 nanoparticles in aqueous solutions. Water Research 42(19), 4878–4884. doi:10.1016/j. watres.2008.09.027

Kwok KW, Auffan M, Badireddy AR, Nelson CM, Wiesner MR, Chilkoti A, Liu J, Marinakos SM, Hinton DE. 2012. Uptake of silver nanoparticles and toxicity to early life stages of Japanese medaka (Oryzias latipes): effect of coating materials. Aquatic Toxicology 120(121), 59-66. doi: 10.1016/j.aquatox.2012.04.012.

Laban G, Nies LF, Turco RF, Bickham JW, Sepulveda MS. 2010. The effects of silver nanoparticles on fathead minnow (Pimephales promelas) embryos. Ecotoxicology 19(1), 185-195. DOI: 10.1007/s10646-009-0404-4

Lancaster T, Stead LF. 2012. Silver acetate for smoking cessation. The Cochrane Collaboration. (Online) 9, CD000191. DOI: 10.1002/14651858.CD000191.

Lansdown A. 2006. Silver in health care: antimicrobial effects and safety in use. Current Problems in Dermatology 33, 17-34. DOI: 10.1159/000093928.

Larese FF, Dagostin F, Crosera M, Adami G, Renzi N, Bovenzi M, Maina G. 2009. Human skin penetration of silver nanoparticles through intact and damaged skin. Toxicology 255(1-2), 33–37. doi:10.1016/j.tox.2008.09.025

Lee B, Duong C, Cho J, Lee J, Kim K, Seo Y, Kim P, Choi K, Yoon J. 2012. Toxicity of Citrate-Capped Silver Nanoparticles in Common Carp (Cyprinus carpio). Journal of Biomedicine and Biotechnology 2012, 262670. doi: 10.1155/2012/262670.

Lee BC, Kim J, Cho JG, Lee JW, Duong CN, Bae E, Yi J, Eom IC, Choi K, Kim P, Yoon J. 2014. Effects of ionization on the toxicity of silver nanoparticles to Japanese medaka (Oryzias latipes) embryos. Toxic/Hazardous Substances and Environ-mental Engineering 49(3), 287-93. doi: 10.1080/10934529.2014. 846614.

Lee HJ, Yeo SY, Jeong SH. 2003. Antibacterial effect of nanosized silver colloidal solution on textile fabrics. Journal of Materials Science 38(10), 2199-2204. DOI: 10.1023/A: 1023736416361.

Lesniak W, Bielinska AU, Sun K, Janczak KW, Shi X, Baker JR, Balogh LP, 2005. Silver /dendrimer nanocomposites as biomarkers: Fabrication, characterization, in vitro toxicity, and intracellular detection. Nano Letters 5(11), 2123-2130. DOI: 10.1021/nl051077u.

Li Q, Mahendra S, Lyon, DY, Brunet L, Liga MV, Li D, Alvarez PJJ. 2008. Antimicrobial nanomaterials for water disinfection and microbial control: potential applications and implications. Water Research 42 (18), 4591–4602. doi: 10.1016/j.watres.2008.08.015.

Luoma SN, Rainbow PS. 2008. Metal contamination in aquatic environments: science and lateral management. Journal of Fish Biology 75, 1911–1912. DOI: 10.1111/j.1095-8649.2009.02440_4.x.

Massarsky A, Abraham R, Nguyen KC, Rippstein P, Tayabali AF, Trudeau VL, Moon TW. 2014. Nanosilver cytotoxicity in rainbow trout (Oncorhynchus mykiss) erythrocytes and hepatocytes. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology; 159, 0-21. doi: 10.1016/j. cbpc.2013.09.008.

Moaddab S, Ahari H, Shahbazzadeh D, Motallebi A, Anvar A, Rahman-Nya J, Shokrgozar MA. 2011. Toxicity study of nanosilver (Nanocid®) on osteoblast cancer cell Line. International Nano Letters 1(1), 11-16.

Monfared AL, Soltani S. 2013. Effects of silver nanoparticles administration on the liver of rainbow trout (Oncorhynchus mykiss): histological and biochemical studies. European Journal of Exponential Biology 3(2), 285-289.

NCCAM. 2012.  Colloidal  Silver  Products. National Center for Complementary and Alternative Medicine. February 2012. https://nccih.nih.gov/health/providers/digest/topsupplements

Nowack B, Bucheli TD. 2007. Occurrence, behavior and effects of nanoparticles in the environment. Environmental Pollution 150(1), 5-22. doi:10.1016/j. envpol.2007.06.006

Nowack B, Krug HF, Height M. 2011. 120 years of nanosilver history: implications for policy makers. Environmental Science and Technology 45(4), 1177– 1183. DOI: 10.1021/es103316q.

Pal S, Tak YK, Song JM. 2007. Does the Antibacterial Activity of Silver Nanoparticles Depend on the Shape of the Nanoparticle? A Study of the Gram-Negative Bacterium Escherichia coli. Applied and Environmental Microbiology 73(6), 1712-1720. doi:10.1128/AEM.02218-06.

Panyala NR, Pena-Mendez EM, Havel J. 2008. Silver or silver nanoparticles: a hazardous threat to the environment and human health? Journal of Applied Biomedicine 6, 117–129.

Perelshtein I, Applerot G, Perkas N, Guibert G, Mikhailov S, Gedanken A. 2008. Sonochemical coating of silver nanoparticles on textile fabrics (nylon, polyester and cotton) and their antibacterial activity. Nanotechnology 19, 245705. doi:10.1088/0957-4484/19/24/245705

Pohle D, Damm C, Neuhof J, Rosch A, Munstedt H. 2007. Antimicrobial properties of orthopaedic textiles after in-situ deposition of silver nanoparticles. Polymers & Polymer Composites 15(5), 357-363. Accession# 28655926.

Powers CM, Yen J, Linney EA, Seidler FJ, Slotkin TA. 2010. Silver exposure in developing Zebrafish (Danio rerio): Persistent effects on larval behavior and survival. Neurotoxicology and Teratology 32(3), 391-397. doi:10.1016/j.ntt.2010.01.009

Project on emerging nanotechnologies. 2013. Available online: http://www. nanotechproject. org/ inventories/consumer/ (accessed on 3 June 2013).

Rajkumar KS, Kanipandian N, Thirumurugan R. 2015. Toxicity assessment on haemotology, biochemical and histopathological alterations of silver nanoparticles-exposed freshwater fish Labeo rohita. Applied Nanoscience DOI 10.1007/s13204-015-0417-7.

Rathore RS, Khangarot BS. 2002. Effect of temperature on the sensitivity of sludge worm Tubifex tubifex (Muller) to selected heavy metals. Ecotoxi-cology and Environmental Safety 53(1), 27–36. doi:10.1006/eesa.2001.2100

Reddy TK, Reddy SJ, Prasad TNVKV. 2013. Effect of Silver Nanoparticles on Energy Metabolism in Selected Tissues of Aeromonas Hydrophila Infected Indian Major Carp, Catla Catla. IOSR Journal of Pharmacy 3(1), 49-55.

Reidy B, Haase A, Luch A, Dawson KA, Lynch A. 2013. Mechanisms of Silver Nanoparticle Release, Transformation and Toxicity: A Critical Review of Current Knowledge and Recommendations for Future Studies and Applications. Materials 6, 2295-2350. doi: 10.3390/ma6062295.

Rivero P, Urrutia A, Goicoechea J, Zamarreno C, Arregui F, Matias I. 2011. An antibacterial coating based on a polymer/solgel hybrid matrix loaded with silver nanoparticles. Nanoscale Research Letters 6(305). doi:10.1186/1556-276X-6-305.

Rosenblatt A, Stamford TCM, Niederman R. 2009. Silver Diamine Fluoride: A Caries Silver-Fluoride Bullet. Journal of Dental Research 88 (2), 116–125. DOI: 10.1177/0022034508329406

Rothkamm K, Lobrich M. 2003. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proceding of National and Academy of Sciences U.S.A. 100, 5057-5062. doi: 10.1073/pnas.0830918100

Russell AD, Hugo WB. 1994. Antimicrobial activity and action of silver. Progress in Medicinal Chemistry 31, 351-370.

Safaepour M, Shahverdi A, Shahverdi H, Khorramizadeh M, Gohari A. 2009. Green synthesis of small silver nanoparticles using geraniol and its cytotoxicity against Fibro sarcoma-Wehi 164. Avicenna Journal of Medical Biotechnology 1(2), 111-115.

Samuel U, Guggenbichler J. 2004. Prevention of catheter-related infections: the potential of a new nano-silver impregnated catheter. International Journal of Antimicrob Agents 23, 75-78. DOI: 10.1016/j.ijantimicag.2003.12.004

Schrand AM, Braydich-Stolle LK, Schlager JJ, Dai L, Hussain SM. 2008. Can silver nanoparticles be useful as potential biological labels? Nanotech-nology 19(2), 235104. doi: 10.1088/0957-4484/19/23/235104

Schultz AG, Ong KJ, MacCormack T, Ma G, Veinot JG, Goss GG. 2012. Silver nanoparticles inhibit sodium uptake in juvenile rainbow trout (Oncorhynchus mykiss). Environmental Science and Technology 46(18), 10295-301. doi: 10.1021/es3017717.

Scown TM, Santos EM, Johnston BD, Gaiser B, Baalousha M, Mitov S, Lead JR, Stone V, Fernandes TF, Jepson M, Van Aerle R, Tyler CR. 2010. Effects of aqueous exposure to silver nanoparticles of different sizes in rainbow trout. Toxicological Science 115(2), 521–534. doi: 10.1093/toxsci/ kfq076.

Shaluei F, Hedayati A, Jahanbakhshi A, Kolangi H, Fotovat M. 2013. Effect of subacute exposure to silver nanoparticle on some hematological and plasma biochemical indices insilver carp (Hypoph-thalmichthys molitrix). Human& Experimental Toxicology 32(12), 1270-7. doi: 10.1177/0960327113485258.

Sharma VK, Siskova KM, Zboril R, Gardea-Torresdey JL. 2014. Organic-coated silver nanoparticles in biological and environmental conditions: fate, stability and toxicity. Advances in Colloid and Interface Science 204, 15-34. doi: 10.1016/j. cis.2013.12.002.

Silver Institute, 2014. World Silver Survey 2014. https://www.silverinstitute.org/ site/supply- demand/

Silver S. 2003. Bacterial silver resistance: Molecular biology and uses and misuses of silver compounds. FEMS Microbiology Reviews 27, 341-353. DOI: http://dx. doi.org/10.1016/S0168-6445(03) 000 47-0

Skirtach AG, Antipov AA, Shchukin DG, Sukhorukov GB. 2004. Remote activation of capsules containing Ag nanoparticles and IR dye by laser light. Langmuir 20(17), 6988-6992. DOI: 10.1021/la048873k

Smith I, Carson B. 1977. Trace metals in the environment. Trace Metals in the Environment 469 pp. ISBN: 978-0-444-50352-7

Soderstjerna E, Bauer P, Cedervall T, Abdshill H, Johansson F. 2014. Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina Studies on Nanoparticle Internalization,  Apoptosis, Oxidative Stress, Glial- and Microglial Activity. PLoS ONE 9(8), e105359. doi:10.1371/journal.pone.0105359.

Sondi I, Sondi BS. 2004. Silver nanoparticles as antimicrobial agent: a case study on E. coli as a model for Gram-negative bacteria. Journal of Colloid and Interface Science 275(1), 177–182. doi:10.1016/j.jcis.2004.02.012

Sung J, Ji J, Yoon J, Kim D, Song M, Jeong J, Han B, Han J, Chung Y, Kim J, Kim T, Chang H, Lee E, Lee J, Yu I. 2008. Lung function changes in Sprague-Dawley rats after prolonged inhalation exposure to silver nanoparticles. Inhalation Toxicology 20(6), 567–574. doi:10.1080/089583707 01874671.

Syrvatka V, Rozgoni I, Slyvchuk Y, Milovanova G, Hevkan I, Matyukha I. 2014. Effects of Silver nanoparticles in Solution and liposomal form on some blood Parameters in female rabbits during fertilization and early embryonic development. Journal of microbiology, biotechnology and food sciences 3 (4), 274-278. ICID: 1092144

Tai SP, Wu Y, Shieh BD, Chen LJ, Lin KJ, Yu CH, Chu SW, Chang CH, Shi XY, Wen YC, Lin KH, Liu TM, Sun CK. 2007. Molecular imaging of cancer cells using plasmonresonant- enhanced third-harmonic-generation in silver nanoparticles. Advance Materials 19, 4520-4523. DOI: 10.1002/adma.200602213.

Taju G, Majeed AS, Nambi KS, Sahul Hameed AS. 2014. In vitro assay for the toxicity of silver nanoparticles using heart and gill cell lines of Catla catla and gill cell line of Labeo rohita. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology 161, 41-52. doi: 10.1016/j.cbpc.2014.01.007.

Tian J, Wong KK, Ho CM, Lok CN, Yu WY, Che CM, Chiu JF, Tam PK. 2007. Topical delivery of silver nanoparticles promotes wound healing. Chem Med Chem 2(1), 129-136. DOI: 10.1002/cmdc.200600171

Tredget EE, Shankowsky HA, Groeneveld A, Burrell R. 1998. A matched-pair randomized study evaluating the efficacy and safety of Acticoat silver-coated dressing for the treatment of burn wounds. Journal of Burn Care & Rehabilitation 19, 531-537. DOI: 10.1097/00004630-199811000-00013.

Walt DR. 2005. Miniature analytical methods for medical diagnostics. Science 308(5719), 217-219. DOI: 10.1126/science.1108161

Wan AT, Conyers RA, Coombs CJ, Masterton JP. 1991. Determination of silver in blood, urine and tissues of volunteers and burn patients. Clinical Chemistry 37(10), 1683-1687.

Webb NA, Wood CM. 1998. Physiological analysis of the stress response associated with acute silver nitrate exposure in freshwater rainbow trout (Oncorhynchus mykiss). Environmental Toxicology and Chemistry 17(4), 579–588. DOI: 10. 1002/etc.5620170408

Weisbarth RE, Gabriel MM, George M, Rappon J, Miller M, Chalmers R, Winterton L. 2007. Creating antimicrobial surfaces and materials for contact lenses and lens cases. Eye and Contact Lens 33, 426-429.

West JL, Halas NJ. 2003. Engineered nanomaterials for biophotonics applications: Improving sensing, imaging, and therapeutics. Annual Review of Biomedical Engineering 5, 285–292. doi: 10.1146/ annurev.bioeng.5.011303.120723.

Wijnhoven SWP, Peijnenburg WJGM, Herberts CA, Hagens WI, Oomen AG, Heugens EHW, Roszek B, Bisschops J, Gösens I, Van de Meent D, Dekkers S, De Jong WH, Van Zijverden M, Sips AJAM, Geertsma RE. 2009. Nano-silver – A review of available data and knowledge gaps in human and environmental risk assessment. Nanotoxicology 3(2), 109-138. doi:10.1080/17435390902725914.

Woodrow Wilson Database. 2015. Nanotechnology consumer product inventory http://www.nanotechproject.org/cpi/about/analysis/.

World Health Organization. 2002. Silver and silver compounds: Environmental aspects. (Concise international chemical assessment document; 44). 1. Silver _ adverse effects 2. Water pollutants, Chemical 3. Risk assessment 4. Environmental exposure I. International Programme on Chemical Safety II. Series ISBN 92 4 153044 8 (NLM Classification: QV 297). ISSN 1020 6167. http://www.who.int/ipcs/publications/cicad /en/cicad 44.Pdf

Wright JB, Lam K, Hansen D, Burrell RE. 1999. Efficacy of topical silver against fungal burn wound pathogens. American Journal of Infection Control 27(4), 344-350. doi:10.1016/S0196-6553(99)70055-6

Wu Y, Zhoua Q, Li H, Liua W, Wanga T, Jianga G. 2010. Effects of silver nanoparticles on the development and histopathology biomarkers of Japanese medaka (Oryzias latipes) using the partial-life test. Aquatic Toxicology 100(2), 160-167. doi: 10.1016/j.aquatox.2009.11.014

Yeo M, Kang M. 2008. Effects of nanometer sized silver materials on biological toxicity during Zebra fish embryogenesis. Bulletin of the Korean Chemical Society 29(6), 1179-1184.

Yon JN, Lead JR. 2008. Manufactured nanoparticles: An overview of their chemistry, interactions and potential environmental implications. Science of Total Environment 400(1-3), 396–414. doi:10.1016/j.scitotenv.2008.06.042.

Yu H, Xu X, Chen X, Lu T, Zhang P, Jing X. 2007. Preparation and antibacterial effects of PVA-PVP hydrogels containing silver nanoparticles. Journal of Applied Polymer Science 103, 125-133. DOI: 10.1002/app.24835

Yves MJ, Philippe H. 2012. Silver as an antimicrobial: Facts and gaps in knowledge. Critical Reviews in Microbiology 39(4), 373-83. doi: 10.3109/1040841X.2012. 713323.

Zhao Y, Shanmukh S, Liu Y, Jones L, Dluhy RA, Tripp RA. 2006. Silver nanorod arrays can distinguish virus strains. Nanotech SPIE Newsroom DOI: 10.1117/2. 1200610.0438.