Welcome to International Network for Natural Sciences | INNSpub

Paper Details

Research Paper | April 1, 2020

| Download 5

Traditional medicinal plants used against diabetes by the tribes of Gajapati district in Odisha – An ethnobotanical exploration

Somani Jethi, Sagar Kumar Mishra, Kunja Bihari Satapathy

Key Words:

Int. J. Biosci.16(4), 354-365, April 2020

DOI: http://dx.doi.org/10.12692/ijb/16.4.354-365


IJB 2020 [Generate Certificate]


The use of herbal medicine is traditionally rooted in India and still an essential part of public healthcare. In recent times, a radically increasing incidence brought Diabetes mellitus and its therapy to the focus of public health interests in India. The current study focuses on the exploration of ethnomedicinal knowledge of plants used against diabetes by the tribes of Gajapati district of Odisha. Preparations of information of the anti-diabetic plants were recorded by the help of the tribes of the district namely Savara, Shaber, Lodha and Kandha. Documentation of aboriginal knowledge related to anti-diabetic properties of native plants was made by interaction with local traditional medicine men. A total of 66 species belonging to 29 families were recorded as being used for the treatment of diabetes in the area under study. The most frequently mentioned plants were Aegle marmelos, Andrographis paniculata, Asparagus racemosus, Azadirachta indica, Clerodendrum philippinum, Cucurma longa, Gymnema sylvestre, Helicteres isora, Hemidesmus indicus, Hybanthus enneaspermus, Pterocarpus marsupium and Woodfordia fructicosa. Most of the herbal preparations of plants used against diabetes were prepared from leaves followed by roots and fruits. However, the available data regarding the anti-diabetic activity of some plants identified in this survey is not sufficient to recommend their use. Pharmacological investigation and clinical intervention studies are required to provide evidence for a safe and effective use of the identified plants in the treatment of diabetes.


Copyright © 2020
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Traditional medicinal plants used against diabetes by the tribes of Gajapati district in Odisha – An ethnobotanical exploration

Ahmed ZB, Yousfi M, Viaene J, Dejaegher B, Demeyer K, Mangelings D, Vander Heyden Y. 2017. Potentially antidiabetic and antihypertensive compounds identified from Pistacia atlantica leaf extracts by LC finger printing. Journal of Pharmaceutical and Biomedical Analysis. 149, 547-556. https://doi.org/10.1016/j.jpba.2017.11.049.

Akah PA, Uzodinma SU, Okolo CE. 2011. Antidiabetic activity of aqueous and methanol extract and fractions of Gongronema latifolium leaves in Alloxan Diabetic Rats. Journal of Applied Pharmacological Science 1, 99-102.

Alarcon-Aguilara FJ, Roman-Ramos R, Perez-Gutierrez S, Aguilar Contreras A. 1998. Contreras-Weber CC & Flores-Saenz JL, Study of the anti-hyperglycaemic effect of plants used as antidiabetics. Journal of Ethnopharmacology 61, 101-110.

Ansari P, Afroz N, Jalil S, Azad SB, Mustakim MG. 2017. Anti-hyperglycaemic activity of Aegle marmelos is partly mediated by increased insulin secretion, α-amylase inhibition, and retardation of glucose absorption. Journal of Paediatric Endocrinology Metabolism 30(1), 37-47. https://doi.org/10.1515/jpem-2016-01.60.

Badole S, Patel N, Bodhankar S, Jain B, Bhardwaj S. 2006. Anti-hyperglycemic activity of aqueous extract of leaves of Cocculus hirsutus in alloxan-induced diabetic mice. Indian Journal Pharmacology 38(1), 49. https://doi.org/10.4103/0253-7613.19853.

Biswas M, Kar B, Bhattacharya S, Kumar RBS, Ghosh AK, Haldar PK. 2011. Antihyperglycemic activity and antioxidant role of Terminalia arjuna leaf in Streptozotocin-induced diabetic rats. Pharmaceutical Biology 49(4), 335-340. https://doi.org/10.3109/13880209.2010.516755.

Brahmachari HD, Augusti KT. 1961. Hypoglycaemic agents from Indian indigenous plants. J Pharm (London) 13(6), 381. https://doi.org/10.1111/j.2042-7158.1961.tb118.39.x.

Chikezie PC, Okey A, Ojiako, Nwufo KC. 2015. Overview of Anti-Diabetic Medicinal Plants. International Journal Diabetes Metabolism 6, 1-7. https://doi.org/10.4172/2155-6156.1000546.

Chopra R, Chopra L, Handa K, Kapur L. 1958. Indigenous Drugs of India, UN Dhar and Sons. Calcutta, India, Edition 2nd, 426.

Gupta NK, Srivastva N, Bubber P, Puri S. 2016 The Antioxidant Potential of Azadirachta indica ameliorates cardioprotection following Diabetic mellitus-Induced Microangiopathy. Pharmacognosy Magazine 12(2), 371-378. https://doi.org/10.4103/0973-1296.185772

Hannan JM, Marenah L, Ali L, Rokeya B, Flatt PR. 2007. Insulin secretory actions of extracts of Asparagus racemosus root in perfused pancreas, isolated islets and clonal pancreatic beta-cells. Journal of Endocrinology 192(1), 159-168. https://doi.org/10.1677/joe.1.07084

Joseph, Jini D. 2011. Insight into the Hypoglycaemic effect of Traditional Indian Herbs used in the treatment of Diabetes. Research Journal Medicinal Plant 5(4), 352-376. https://doi.org/10.3923/rjmp.2011.352.376.

Kar MK, Swain TR, Mishra SK. 2014. Antidiabetic activity of Clerodendrum serratum (L.) Moon leaves in Streptozotocin-induced diabetic rats. Asian Journal of Pharmacology and Clinical Research 7(6), 260-263.

Kar MK, Swain TR, Mishra, SK. 2015. Antidiabetic activity of Clerodendrum philippinum Schauer leaves in Streptozotocin induced diabetic rats. International Journal of Pharmacy and Pharmaceutical Sciences 7(9), 386-389.

Kazeem MI, Dansu TV, Adeola SA. 2013. Inhibitory effect of Azadirachta indica leaf extract on the activities of alpha-amylase and alpha-glucosidase. Pakistan Journal of Biological Sciences 16(21), 1358-1362. https://doi.org/10.3923/pjbs.2013.1358.1362.

Kesari AN, Gupta RK, Watal G. 2005. Hypoglycemic effects of Murraya koenigii on normal and alloxan-diabetic rabbits. Journal Ethnopharmacology 97(2), 247-251. https://doi.org/10.1016/j.jep.2004.11.006

Khaliq F, Parveen A, Singh S, Hussain ME, Fahim M. 2013. Terminalia arjuna Improves cardiovascular autonomic neuropathy in streptozotocin-induced diabetic rats. Cardiovascular Toxicology 13(1), 68-76. https://doi.org/10.1007/s12012-012-9187-6

Kirtikar KR, Basu BD. 1933. Indian Medicinal Plants. 2ndEd., Lalit Mohan Basu Publications, Allahabad. 1052-1054.

Li WL, Zheng HC, Bukuru J. 2004. Natural medicines used in the traditional Chinese medical system for therapy of Diabetes Mellitus. Journal of Ethnopharmacology 92, 1. https://doi.org/10.1016/j.jep.2003.12.031

Ma C, Yu H, Xiao Y, Wang H. 2017. Momordica charantia extracts ameliorate insulin resistance by regulating the expression of SOCS-3 and JNK in type 2 diabetes mellitus rats. Pharmaceutical Biology 55(1), 2170-2177. https://doi.org/10.1080/13880209.2017.1396350

Mahmoud MF, El Ashry FE, El Maraghy NN, Fahmy A. 2017. Studies on the antidiabetic activities of Momordica charantia fruit juice in streptozotocin-induced diabetic rats. Pharmaceutical Biology 55(1), 758-765. https://doi.org/10.1080/13880209.2016.1275026

Maryam R. 2015. A Review, Anti Diabeteic medicinal plants used for diabetes mellitus. Bulletin of Environment, Pharmacology and Life Sciences 4(2), 163-180.

Mekap SK, Sahoo S, Satapathy KB, Mishra SK. 2016. Antidiabetic Evaluation of Leaf Extracts of Naringi crenulata (Roxb.) Nicolson. International Journal for Pharmaceutical Research Scholars 5(2), 218-232.

Mekap SK, Sahoo S, Satapathy KB, Mishra SK. 2016. Evaluation of Antidiabetic Activity of Oxalis corniculata Whole Plant. Research Journal of Pharmaceutical, Biological and Chemical Sciences 7(2), 2142- 2152.

Mekap SK, Sahoo S, Satapathy KB, Mishra SK. 2016. Evaluation of Toddalia asiatica (L.) Lam. leaf extracts for antidiabetic activity. Pharmaceutical and Biological Evaluations 3(1), 115-125.

Mudi SR, Akhter M, Biswas SK, Muttalib MA, Choudhury S. 2017.  Effect of aqueous extract of Aegle marmelos fruit and leaf on glycemic, insulinemic and lipidemic status of type-2 diabetic model rats. Journal of Complementary and Integrative Medicine 14(2), 145-149. https://doi.org/10.1515/jcim-2016-01.11.

Nagappa AN, Thakurdesai PA, Venkat Rao N, Jiwan S. 2003. Antidiabetic activity of Terminalia catappa Linn. Fruits. Journal of Ethnopharmacology 88, 45-50. https://doi.org/10.1016/S0378-8741(03)00208-3

Nampoothiri SV, Prathapan A, Cherian OL, Raghu KG, Venugopalan VV.  2011. In vitro antioxidant and inhibitory potential of Terminalia bellerica and Emblica officinalis fruits against LDL oxidation and key enzymes linked to type 2 diabetes. Food and Chemical Toxicology 49(1), 25-131. https://doi.org/10.1016/j.fct.2010.10.006.

Narayan K, Sastry KNV. 1975. The hypoglycemic effect of Murraya koenigii in normal and alloxan diabetic dogs. Mysore Journal of Agricultural Sciences 9, 132-136.

Ohadoma SC, Michael HU. 2011. Effects of Co-Administration of Methanol Leaf Extract of Catharanthus roseus on the Hypoglycaemic Activity of Metformin and Glibenclamide in Rats. Asian Pacific Journal of Tropical Medicine 4(6), 475-477.

Oke JM. 1998. Antidiabetic potency of pawpaw. African Journal of Biomedical Research 1, 31-34.

Panaskar SN, Joglekar MM, Taklikar SS, Haldavnekar VS, Arvindekar AU. 2013. Aegle marmelos leaf extract prevents secondary complications in streptozotocin-induced diabetic rats and demonstration of limonene as a potent antiglycating agent, Journal of Pharmacy and Pharmacology 65(6), 884-894. https://doi.org/10.1111/jphp.12044

Pari L, Satheesh MA. 2004. Anti-diabetic activity of Boerhaavia diffusa effect on hepatic key enzymes in experimental diabetes. Journal of Ethnopharmacology 91(1), 109-113. https://doi.org/10.1016/j.jep.2003.12.013

Perez Gutierrez RM, de Jesus Martinez Ortiz M. 2013. Beneficial effect of Azadirachta indica on advanced glycation end-product in streptozotocin-diabetic rat. Pharmaceutical Biology 52(11), 1435-1444. https://doi.org/10.3109/13880209.2014.895389

Rahman AU, Zaman K. 1989. Medicinal plants with hypoglycaemic activity. Journal of Ethnopharmacology 26, 155. https://doi.org/10.1016/0378-8741(89)90112-8

Rajalakshmi M, Anita R. 2016. β-cell regenerative efficacy of a polysaccharide isolated from methanolic extract of Tinospora cordifolia stem on streptozotocin- induced diabetic Wistar rats. Chemico-Biological Interactions 243, 45-53. https://doi.org/10.1016/j.cbi.2015.11.021

Sangetha MK, Mohana Priya CD, Vasanthi HR. 2013. Anti-diabetic property of Tinospora cordifolia and its active compound is mediated through the expression of Glut-4 in L myotubes. Phytomedicine 20(3-4), 246-248. https://doi.org/10.1016/j.phymed.2012.11.006

Satyanarayana T, Katyayani B, Latha HE, Mathews AA, Chinna EM. 2006. Hypoglycemic and antihyperglycemic effect of alcoholic extract of Euphorbia leucophylla and its fractions in normal and in alloxan induced diabetic rats. Pharmacognosy Magazine 2(8), 244.

Satyanarayana T, Katyayani BM, Latha HE. 2006. Hypoglycemic and antihyperglycemic effect of alcoholic extract of Euphorbia leucophylla and its fractions in normal and in alloxan induced diabetic rat. Pharmacognosy Magazine 2, 244.

Shaw JE, Sicree RA, Zimmet PA. 2018. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice 87(1), 4-14. https://doi.org/10.1016/j.diabres.2009.10.007

Somania R, Singhai AK, Shivgunde P, Jain D. 2012. Asparagus racemosus ameliorates early diabetic nephropathy in STZ induced diabetic rats. Indian Journal Experimental Biology 50(7), 469-475.

WHO. 2000. General guidelines for methodologies on research and evaluation of traditional medicine. Geneva Switzerland WHO/EDM/TRM/1, 1-80.

Yadav S, Vats V, Dhunnoo Y, Grover JK. 2002. Hypoglycemic and antihyperglycemic activity of Murraya koenigii leaves in diabetic rats. Journal of Ethnopharmacology 82, 111-116. https://doi.org/10.1016/S0378-8741(02)00167-8


Style Switcher

Select Layout
Chose Color
Chose Pattren
Chose Background