Transmission routes of hepatitis C virus in Rahim Yar Khan: hospital based study

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Research Paper 01/11/2019
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Transmission routes of hepatitis C virus in Rahim Yar Khan: hospital based study

M. Ali Malik, M.A. Rehman, Nadia Usman, Mehreen Lateef, Shizma Junejo
Int. J. Biosci.15( 5), 418-424, November 2019.
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Abstract

Hepatitis C virus (HCV) is the dominant cause of chronic liver disease and responsible foraround eight million people in Pakistan as per national hepatitis survey. This study aimed atexploring causes and risks related to increasing rate of occurrence of disease and to explore the route of transmission of hepatitis C virus in patients visiting the Sheikh Zayed Hospital in Rahim Yar Khan. This cross-sectional study included 684paticipants, visiting Sheikh Zayed Hospital in Rahim Yar Khan. The  questionnaires were filled by all participants and  included  information related to dietary pattern, disease history, risk factors and risk behavior like history of blood transfusions, surgical intervention, injection drug use, sexually transmitted diseases, accidental needle stick injuries treated by traditional doctors.  Blood samples of the patients were collected to diagnose hepatitisC by immuno-chromatographic methods (ICT) and then further confirmed by PCR technique. Most common route of HCV transmission was unknownroute, 57.5 % (n=363) followed by dental procedures, 17.1% (n= 117) while third most common route of transmission was surgical procedures 12.0 %. The association between route of transmission and duration of disease was highly significant (p< 0.001).The study revealed that dental and surgical procedures were identified as main routes of transmission of hepatitisbut majority of patients were unaware of route of acquiring hepatitis C (HCV) infection. Hepatitis awareness programs, prevention and treatment plans should be communicated to general population for controlling enhanced burden ofHepatitus C in small cities like RahimYar Khan.

VIEWS 14

Adeyemi AA, Omolade OA, Raheem-Ademola RR. 2013.  Immunochromatographic Testing Method for Hepatitis B, C in Blood Donors Journal of Antivirals& Antiretrovirals 3, 1-2.

Akhtar N, Ilyas M, Muhammad K, Shams S, Saeed K, Asadullah. 2016. Prevalence of Hepatitis C virus infections among the general population of Buner, Khyber Pakhtunkhwa, Pakistan. Biomedical Research and Therapy 3, 1003-1017.

Al Kanaani Z, Mahmud S, Kouyoumjian SP, Abu-Raddad LJ. 2018. The epidemiology of hepatitis C virus in Pakistan: systematic review and meta-analyses. Royal Society Open Science 5, 180257.

Al A, Ahmad H, Ali I, Khan S, Zaidi G,   Idrees M. 2010. Prevalence of active hepatitis c virus infection in district Mansehra Pakistan. Virology Journal 7, 334.

Aziz H, Raza A, Murtaza S, Waheed Y, Khalid, A, Irfan J, Athar MA. 2013.  Molecular epidemiology of hepatitis C virus genotypes in different geographical regions of Punjab Province in Pakistan and a phylogenetic analysis. International Journal of Infectious Diseases 17, e247–e253.

Bruggmanna P, Grebely J. 2015.  Prevention, treatment and care of hepatitis C virus infection among people who inject drugs. International Journal of Drug Policy 26, S22–S26.

Hafeez-ud-din, Siddiqui TS, Lahrasab W, Sharif MA. 2012.  Prevalence of Hepaitis B and C in healthy adult males of paramilitary personnel in Punjab. Journal of Ayub Medical College Abbottabad 24, 3-4.

Jilani K, Zulfiqar B, Memon QB, Fahim MF. 2017. Frequency and the risk factors of hepatitis C virus in pregnant women; A hospital based descriptive study in Gadap Town Karachi. Pakistan Journal of Medical Sciences 33, 1265-1268.

Khan M, Jalil F, Din M, Ali S, Ahmad, A. 2018. Seroprevalence and Risk Factors of Hepatitis C Virus (HCV) in Tehsil Takht Bhai District Mardan, KPK, Pakistan, International Journal of Biosciences 12, 249-254.

Kwon YC, Ray RB, Ray R. 2014. Hepatitis C virus infection: establishment of chronicity and liver disease progression. Experimental and Clinical Sciences Journal 13, 977-996.

Lim AG, Qureshi H, Mahmood H, Hamid S, Davies CF, Trickey A, Vickerman P. 2018. Curbing the hepatitis C virus epidemic in Pakistan: the impact of scaling up treatment and prevention for achieving elimination, International Journal of Epidemiology 550–560.

Mahmood H, Raja R. 2017. Risk Factors of Hepatitis C in Pakistan. Gastroenterology & Hepatology 7, 00259.

Mati Ullah,   Hasan F, Najmudin, Alam MM, Zaidi SSZ, Rana MS. 2016.  Seroprevalence of Hepatitis C Virus Infection in Kohat Division, Khyber Pakhtoonkhwa, Pakistan. Pakistan Journal of Zoology 48, 1721-1725.

Mohamed AA,  Elbedewy TA, El-Serafy M, El-Toukhy N, Ahmed W, El Din  ZA. 2015. Hepatitis C virus: A global view. World Journal of Hepatology 7, 2676-2680.

Morozov VA, Lagaye S. 2018. Hepatitis C virus: Morphogenesis, infection and therapy. World Journal of Hepatology 10, 172-351.

Mujtaba  G, Jahan S, Khaliq S, Mahmood  N, Javed  FT, Choudhry N, Aslam A, Faiz M. 2011. Current Status of Transmission Risk Factors and Genotypes of Hepatitis C Virus, In Punjabi Population of Pakistan. International Journal for AgroVetenary and Medical Sciences 5, 271-282.

Nazir N, Jan MR, Ali A, Asif M, Idrees M,  Nisar  El-Salam A. 2017. Prevalence of hepatitis-C virus genotypes and potential transmission risks in Malakand Khyber Pakhtunkhwa.  Virology Journal 14, 160.

Rathore JA, Shah MA, Mehraj A. 2012.   Hepatitis C virus transmission risk factors. Journal of Ayub Medical College Abbottabad 24, 3-4.

Shon HS, Choi HY, Kim JR,  Ryu SY,  Lee YJ,  Lee MJ,  KM. 2015.  Comparison and analysis of the prevalence of hepatitis C virus infection by region in the Republic of Korea during 2005–2012. Clinical and Molecular Hepatology 21, 249-256.

Umar M, Bilal M. 2012. Hepatitis C, A Mega Menace: A Pakistani Perspective. Journal of Pakistan Medical Students 2.

Waheed Y, Najmi M H, Aziz H, Waheed H, Imran M,  Safi SZ. 2017. Prevalence of hepatitis C in people who inject drugs in the cities of Rawalpindi and Islamabad, Pakistan. Biomedical Reports 7, 263-266.

Waheed Y, Shafi T, Safi SZ, Qadri I. 2009.  Hepatitis C virus in Pakistan: A systematic review of prevalence, genotypes and risk factors. World Journal of Gastroenterology 15, 5647-5653.

Waheed Y, Saeed U, Safi SZ, Chaudhry WN, Qadri I.  2010. Awareness and risk factors associated with barbers in transmission of hepatitis B and C from Pakistani population: barber’s role in viral transmission. Asian Biomedicine 4, 435-442.

Yeung CY, Lee HC, Chan  WT, Jiang CB, Chang SW, Chuang CK. 2014. Vertical transmission of hepatitis C virus: Current knowledge and perspectives. World Journal of Hepatology 6, 643-651.

Zameer M, Shazad F, Saeed M, Aziz S, Nazish    Hussain S. 2016. Comparison between ELISA and ICT techniques for the detection of Anti HCVAntibody among blood donors. Biomedica 32.