Paper Details

Tumor necrosis factor alpha as inflammatory cytokine is not associated with cardiovascular risk factors in presence obesity

Eizadi Mojtaba, Dooaly Hussein, Samarikhalaj Hamidreza

DOI: https://dx.doi.org/10.12692/ijb/5.10.183-188

Int. J. Biosci. 5(10), 183-188. November, 2014. (PDF)

Abstract:

It is generally accepted that obesity is associated with systemic inflammation and increased cardiovascular risk factor, although the physiopathological mechanisms underlying these associations are largely unknown. To analyze whether lipid profile of cardiovascular risk factors are associated with serum level of tumor necrosis factor alpha (TNF-α) in presence to obesity, thirty abdominally obese men (BMI ≥30 kg/m2) aged 34 to 41 years were participated in this study by accessible sampling. All participants reported being weight stable (±1kg) for 6 months prior to the study and engaged in physical activity less than once per week. Blood was collected from was drawn from the antecubital vein of all subjects after an overnight fast between 8:00 a.m. and 9:00 a.m. blood samples were used for evaluation serum  TNF-α  and lipid profile markers such as triglyceride (TG), total cholesterol (TC), low density lipoprotein (LDL) and high density lipoprotein (HDL). Pearson’s correlation coefficients were used to evaluate the correlations between serums TNF-α and lipid profile markers.  Findings from statistical analysis showed no significant correlation in serum TNF-α with TG, TC and LDL. Serum TNF-α was negatively correlated with HDL cholesterol in studied subjects (p = 0.002, r = 0.78). Based on these data, apart from HDL, serum TNF-α as inflammatory cytokine can not predict other cardiorespiratory risk factor in obese subjects directly.