Welcome to International Network for Natural Sciences | INNSpub

Paper Details

Research Paper | February 1, 2014

VIEWS 1
| Download 1

Tumor necrosis factor alpha in smokers and non-smokers

Behbudi Laleh, Sedaghati Saeid, Sokhanguei Yahya, Afsharmand Zohreh

Key Words:


J. Bio. Env. Sci.4(2), 159-164, February 2014

Certification:

JBES 2014 [Generate Certificate]

Abstract

Previous investigations have described a positive association between smoking and systemic inflammation. To compare serum Tumor necrosis factor alpha (TNF-α) between smoker and non-smoker men, fifteen healthy adult smoker and the same number non-smoker men matched for age and body mass index participated in this study by accessible sampling. To determine difference in serum TNF-α between two group, their blood samples were collected an overnight fast. Independent sample T-test was used to compare the serum levels of TNF-α between smoker and non smoker subjects. There was not significant difference in serum TNF-α between smoker and non-smoker groups. These data do not support the inflammatory property of smoking. Further studies are needed to clarify possible mechanisms by which smoking affect systemic inflammation by TNF-α or other cytokines.

VIEWS 1

Copyright © 2014
By Authors and International Network for
Natural Sciences (INNSPUB)
http://innspub.net
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Tumor necrosis factor alpha in smokers and non-smokers

Chung KF. 2001. Cytokines in chronic obstructive pulmonary disease. European Respiratory Journal 5, 50-59.

Churg A, Dai J, Tai H, Xie C, Wright JL. 2002. Tumor necrosis factor-alpha is central to acute cigarette smoke-induced inflammation and connective tissue breakdown. American Journal of Respiratory and Critical Care Medicine 166, 849-854.

Churg A, Wang RD, Tai H, Wang X, Xie C, Wright JL. 2004. Tumor necrosis factor-á drives 70% of cigarette smoke-induced emphysema in the mouse. American Journal of Respiratory and Critical Care Medicine 17, 492-498.

Dilyara G. Yanbaeva, Mieke A. Dentener, Eva C. 2007. Creutzberg, Geertjan Wesseling and Emiel FM. Wouters. Systemic Effects of Smoking. Chest 5, 1557-1566.

Gerszten RE, Garcia-Zepeda EA, Lim YC, Yoshida M, Ding HA, Gimbrone MA Jr, Luster AD, Luscinskas FW, Rosenzweig A. 1999. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398, 718–23.

Jovinge S, Hamsten A, Torvall P, Proudler A, Bavenholm P, Ericsson CG, Godland I, de farire Y. 1998. Evidence for a role of tumor necrosis factor alpha in disturbances of triglyceride and glucose metabolism predisposing to coronary heart disease. Metabolism 47, 113–8

Keatings VM, Collins PD, Scott DM, Barnes PJ. 1996. Differences in interleukin-8 and tumor necrosis factor-á in induced sputum from patients with chronic obstructive pulmonary disease or asthma. American Journal of Respiratory and Critical Care Medicine 153, 530-534.

Keatings VM, Collins PD, Scott DM, Barnes PJ. 1996. Differences in interleukin-8 and tumor necrosis factor-á in induced sputum from patients with chronic obstructive pulmonary disease or asthma. American Journal of Respiratory and Critical Care Medicine 153, 530- 534.

Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Journal of Clinical Investigation 95, 2111–9.

Kuschner WG, D’Alessandro A, Wong H, Blane PD. 1996. Dose-dependent cigarette smoking-related inflammatory responses in healthy adults. European Respiratory Journal 9, 1989-1994.

McCrea KA, Ensor JE, Nall K, Bleecker ER, Hasday JD. 1994. Altered cytokine regulation in the lungs of cigarette smokers. American Journal of Respiratory and Critical Care Medicine 150(3), 696-703.

McCrea KA, Ensor JE, Nall K, Bleecker ER, Hasday JD. 1994. Altered cytokine regulation in the lungs of cigarette smokers. American Journal of Respiratory and Critical Care Medicine 150(3), 696 – 703.

Merghani TH, Saeed A, Alawad A. 2012. Changes in plasma IL4, TNFá and CRP in response to regular passive smoking at home among healthy school children in Khartoum, Sudan. African Health Sciences 12(1), 41-47.

Miller GD, Nicklas DJ, Loeser RF. 2008. Inflammatory biomarkers and physical function in older, obese adults with knee pain and self-reported osteoarthritis after intensive weight-loss therapy. Journal of the American Geriatrics 644, 51-56.

Mukhopadhyay S, Hoidal JR, Mukherjee TK. 2006. Role of TNFalpha in pulmonary pathophysiology. Respiratory Research 7, 125.

Murray DR, Freeman GL. 2003. Proinflammatory cytokines. Predictors of a failing heart? Circulation 107, 1460–2.

Pang B, Wang C, Weng X, Tang X, Zhang H, Niu S, Mao Y, Xin P and Huang X. 2000. Lung injury caused by passive smoking and its effects on cytokines in rats. Zhonghhua Yu Fang Yi Xue Za Zhi 34(2), 104-105.

Patrícia ES. 2011. Physical Exercise Improves Insulin Sensitivity of Rats Exposed to Cigarette Smoke. Revista Brasileira de Medicina do Esporte 17(3), 202-206.

Pessina GP, Paulesu L, Corradeschi F, Luzzi E, Tanzini M, Aldinucci C, Stefano AD, Bocci V. 1993. Chronic cigarette smoking enhances spontaneous release of tumour necrosis factor-á from alveolar macrophages of rats. Mediators of Inflammation 2(6), 423 –428.

Pessina GP, Paulesu L, Corradeschi F, Luzzi E, Tanzini M, Aldinucci C, Stefano AD, Bocci V. 1993. Chronic cigarette smoking enhances spontaneous release of tumour necrosis factor-á from alveolar macrophages of rats. Mediators of Inflammation 2(6), 423 –428.

Qin  B,  Anderson  RA,  Adeli  K.  2008.  Tumor necrosis factor-a directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling. American Journal of Physiology – Gastrointestinal and Liver Physiology 294, 1120–9.

Tappia PS, Troughton KL, Langley-Evans SC, Grimble RF. 1995. Cigarette smoking influences cytokine production and antioxidant defenses. Clinical Science (London) 88(4), 485-489.

Tappia PS, Troughton KL, Langley-Evans SC, Grimble RF. 1995. Cigarette smoking influences cytokine production and antioxidant defenses. Clinical Science (London) 88(4), 485 -489.

Weiss ST. 2005. Obesity: insight into the origins of asthma. Nature Immunology 6, 537-539.

Ye J. 2008. Regulation of PPAR gamma function by TNF-alpha. Biochemical and Biophysical Research Communications 374, 405–8.

SUBMIT MANUSCRIPT

Style Switcher

Select Layout
Chose Color
Chose Pattren
Chose Background