Wound Healing Activity of Ointment infused with Aqueous Extracts of Plants Used by the Agtas of Peñablanca and Malauegs of Rizal in the Province of Cagayan, Northern Philippines
Paper Details
Wound Healing Activity of Ointment infused with Aqueous Extracts of Plants Used by the Agtas of Peñablanca and Malauegs of Rizal in the Province of Cagayan, Northern Philippines
Abstract
Poor wound healing hinders the resolution of skin problems that become enlarged and infected that causes a significant negative impact on the quality of life. The study aimed to investigate the wound healing activity of the plants used by indigenous groups (Agtas and Malauegs) in the Philippines, Donax cannaeformis and Chlorophytum comosus var. variegatum. In the present study, ointments with aqueous extracts of these plants were administered topically to the Sprague Dawley rats. Evaluation of wound healing activity was done using the excision, incision, and burn wound models. In each model, Treatment A has 100% D. cannaeformis; B=100% C. comosus; C=50% D. cannaeformis and 50% C. comosus; D=75% D. cannaeformis and 25% C. comosus; E= 25% D. cannaeformis and 75% C. comosus; F=Positive control. All wound model rats were treated for fifteen days, and the wound healing activity was assessed by percentage wound contraction. The results showed that the ointments containing the plant extracts are not significantly different from the positive control. That means these can be used as an alternative herbal remedy to commercial products. However, tensile strength and histopathological studies of the granulation tissue and free radical scavenging activity are recommended to fully determine the activity of the plant extracts.
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