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Wound Healing Activity of Ointment infused with Aqueous Extracts of Plants Used by the Agtas of Peñablanca and Malauegs of Rizal in the Province of Cagayan, Northern Philippines

Research Paper | October 1, 2021

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Bernadette Y. Cauilan, Jamaica M. Danga, Marvin Henesse T. Lungan, Maria Louisa L. Pallingayan, Jinky Marie T. Chua, Julius T. Capili, Ramelo B. Ramirez Jr

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Int. J. Biosci.19( 4), 166-172, October 2021

DOI: http://dx.doi.org/10.12692/ijb/19.4.166-172


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Poor wound healing hinders the resolution of skin problems that become enlarged and infected that causes a significant negative impact on the quality of life. The study aimed to investigate the wound healing activity of the plants used by indigenous groups (Agtas and Malauegs) in the Philippines, Donax cannaeformis and Chlorophytum comosus var. variegatum. In the present study, ointments with aqueous extracts of these plants were administered topically to the Sprague Dawley rats. Evaluation of wound healing activity was done using the excision, incision, and burn wound models. In each model, Treatment A has 100% D. cannaeformis; B=100% C. comosus; C=50% D. cannaeformis and 50% C. comosus; D=75% D. cannaeformis and 25% C. comosus; E= 25% D. cannaeformis and 75% C. comosus; F=Positive control. All wound model rats were treated for fifteen days, and the wound healing activity was assessed by percentage wound contraction. The results showed that the ointments containing the plant extracts are not significantly different from the positive control. That means these can be used as an alternative herbal remedy to commercial products. However, tensile strength and histopathological studies of the granulation tissue and free radical scavenging activity are recommended to fully determine the activity of the plant extracts.


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Wound Healing Activity of Ointment infused with Aqueous Extracts of Plants Used by the Agtas of Peñablanca and Malauegs of Rizal in the Province of Cagayan, Northern Philippines

Azliza MA, Ong HC. 2012. Ethno-medicinal Resources Used by the Temuan in Ulu Kuang Village. Studies on Ethno-Medicine 6(1), 17-22. https://doi.org/10.1080/09735070.2012.11886415

Boakye YD, Agyare C, Ayande, GP, Titiloye N, Asiamah EA, & Danquah KO. 2018. Assessment of Wound-Healing Properties of Medicinal Plants: The Case of Phyllanthus muellerianus. Frontiers in pharmacology 9, 945. https://doi.org/10.3389/fphar.2018.00945

Capili JT, Pastores NM. 2017. Effectiveness of Spider Plant (Chlorophytum comosum var. variegatum) in Skin Burns of Albino Rats (Rattus norvegicus strain Sprague Dawley) Compared to Silver Sulfadiazine. IAMURE International Journal of Ecology and Conservation, 22(1). Retrieved from http://ejournals.ph/form/cite.php?id=12495

Chua JT. 2019. Wound Healing Activity of Aqueous Extracts of Common Legumes. IAMURE International Journal of Ecology and Conservation, 29(1). Retrieved from http://ejournals.ph/form/cite.php?id=14896

Daud JM. 2011. Phytochemicals Screening and Antioxidant Activities of Malaysian Donax Grandis Extracts. European Journal of Scientific Research, 61(4), 572-577.

Garg VK, Khosa RL, Paliwal SK. 2009. Wound healing activity of aqueous extract of Cynodon dactylon. Pharmacologyonline 1, 1246-55.

Jha RK, Garud N, Nema RK. 2009. Excision and incision wound healing activity of flower head alcoholic extract of Sphaeranthus indicus Linn. in albino rats. Global Journal of Pharmacology 3(1), 32-7.

Kumar B, Vijayakumar M, Govindarajan R, Pushpangadan P. 2007. Ethnopharmacological approaches to wound healing–exploring medicinal plants of India. Journal of Ethnopharmacology, 114(2), 103-13. https://doi.org/10.1016/j.jep.2007.08.010

Martin P. 1997. Wound healing–aiming for perfect skin regeneration. Science 276(5309), 75-81. https://doi.org/10.1126/science.276.5309.75

Modak M, Barde M, Modak MD, Barde MP. 2017.  Efficacy of an Ayurvedic Formulation for Mild-to-moderate Osteoarthritis:  A Phase 3, Randomized   Controlled   Study. Alternative   Therapies   in   Health   &   Medicine 23(1).

Narayan S, Sasmal D, Mazumder PM. 2011. Evaluation of the Wound Healing Effect of Herbal Ointment Formulated With Salvia Splendens (Scarlet Sage). International Journal of Pharmacy and Pharmaceutical Sciences 3(3), 195-199.

Odimegwu DC, Ibezim EC, Esimone CO, Nworu CS, Okoye FB. 2008. Wound healing and antibacterial activities of the extract of Dissotis theifolia (Melastomataceae) stem formulated in a simple ointment base. Journal of medicinal plants research 2(1), 1011-6.

Priya KS, Arumugam G, Rathinam B, Wells A, Babu M. 2004. Celosia argentea Linn. Leaf extract improves wound healing in a rat burn wound model. Wound repair and regeneration 12(6), 618-25. https://doi.org/10.1111/j.1067-1927.2004.12603.x

Rupesh T, Nitika J, Raghvendra P, Sardul SS. 2011. Practices in Wound Healing Studies of Plants. Evidence-Based Complementary and Alternative Medicine, 2011. https://doi.org/10.1155/2011/438056

Sharma S, Mehta BK, Mehta D, Nagar H, Mishra A. 2012. A review on pharmacological activity of Syzygium cumini extracts using different solvent and their effective doses. International Research Journal of Pharmacy 3(12), 54-58.