Phenotypic profiles of nasal methicillin resistant Staphylococcus aureus from asymptomatic children of Iligan City
Paper Details
Phenotypic profiles of nasal methicillin resistant Staphylococcus aureus from asymptomatic children of Iligan City
Abstract
Methicillin resistant Staphylococcus aureus (MRSA) has become a global healthcare threat, even colonizing healthy asymptomatic individuals with no traditional risk factors for MRSA. The objectives of this study was to determine sensitivity patterns of MRSA, isolated from healthy asymptomatic children, against three antibiotics commonly used to treating outpatients; and to establish the prevalence of multidrug resistant MRSA strains. Modified Kirby Bauer disc diffusion technique was employed to determine the susceptibilities, with zones of inhibition interpreted according to the Clinical and Laboratory Standard Institute (CLSI) guidelines. Tetracyline is the best choice for empiric treatment of suspected MRSA infections with the lowest resistance at 3%. Clindamycin and ampicillin had resistance rates of 28% and 45% respectively. Fifteen percent of the MRSA isolates were multidrug resistant. Routine screening of clinical S. aureus isolates for methicillin resistance, regular surveillance studies as well as institution of infection control measures and antibiotic stewardship programme are recommended.
Aqel AA, Alzoubi HM, Vickers A, Pichon B, Kearns AM. 2015. Molecular epidemiology of nasal isolates of methicillin-resistant Staphylococcus aureus from Jordan. Journal of Infection and Public Health 8(1), 90-97. https://doi.org/10.1016/j.jiph.2014.05.007
Bernardo WL, Boriollo MFG, Goncalves RB, Hofling JF. 2005. Staphylococcus aureus Ampicillin-Resistant from the Odontological Clinic. Revista do Instituto de Medicina Tropical de São Paulo 47(1), 19-24.
Coyle MB. 2005. Manual of Antimicrobial Susceptibility Testing. American Society for Microbiology. ISBN 1-55581-349-6.
Diekema DJ, Pfaller MA, Schmitz FJ, Smayevsky J, Bell J, Jones RN, Beach M, Sentry Participants Group. Survey of infections due to Staphylococcus species: frequency of occurrence and antimicrobial susceptibility of isolates collected in the United States, Canada, Latin America, Europe, and the Western Pacific Region for the SENTRY Antimicrobial Surveillance Program, 1997–1999. Clinical Infectious Disease 32, S114-32.
Eckart RE, Hospenthal DR, Fishbain JT. 2000. Response of Complicated Methicillin-Resistant Staphylococcus aureus Endocarditis to the Addition of Trovafloxacin. Pharmacotherapy 20(5), 589-592.
Fishovitz J, Hermoso J, Chang M, Mobashery S. 2014. Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus. IUBMB Life. 66(8), 572–577. https://10.1002/iub.1289
Hizel K, Aktap EF, Penol E. 1997. Staphylococcus aureus in Hospital Personnel: Carriage and Antibtiotic Susceptibility. Gazi Medical Journal 8, 23-26.
Lee AS, Lencastre dH, Javier G, Kluytmans J, Malhotra-Kumar S, Peschel A, Harbarth S. 2018. Methicillin-resistant Staphylococcus aureus. Nature Reviews Disease Primers 4, 18033. https://doi.org/10.1038/nrdp.2018.33
Tiwari HK, Sapkota D, Sen MR. 2008. High prevalence of multidrug-resistant MRSA in a tertiary care hospital of northern India. Infections and Drug Resistance 1, 57–61.
Trzcinzki K, Cooper BS, Hryniewicz W, Dowson CG. 2000. Expression of resistance to tetracyclines in strains of methicillin-resistant Staphylococcus aureus. Journal of Antimicrobial Chemotherapy 45(6), 763-770. https://doi.org/10.1093/jac/45.6.763
Lucilyn L. Maratas, Leonell Albert L. Quitos, 2018. Phenotypic profiles of nasal methicillin resistant Staphylococcus aureus from asymptomatic children of Iligan City. Int. J. Biosci., 13(3), 109-113.
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