Therapeutic potential of mangrove and its associate plant extracts from thane creek, against human respiratory tract MDR pathogens
Paper Details
Therapeutic potential of mangrove and its associate plant extracts from thane creek, against human respiratory tract MDR pathogens
Abstract
The present study investigates antibacterial activities of four mangrove plants, Avicennia marina, Avicennia officinalis, Salvadora persica and Sesuvium portulacastrum against Respiratory tract multidrug resistance pathogens like Mycobacterium tuberculosis, Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus. Mangrove plant extracts were obtained by sequential soxhlet extraction method in methanol and ethyl acetate solvents. These extracts were screened for antibacterial activity, synergistic activity, potentiation effect by agar well diffusion method and phytochemical analysis was also done. Ethyl acetate extract exhibited the highest antibacterial activity than methanolic extract of all the four plants. Extract of A. marina and S. portulacastrum exhibited highest antibacterial activity as compared to that of other two plant extracts. While in case of synergistic effect, combination of ethyl acetate extracts of all four plants exhibited more potency than other combinations against M.tuberculosis. In potentiation activity, A.marina and S. portulacastrum extracts were individually combined with the antibiotic Gentamicin and exhibited higher activity than other extracts. All extracts were more potent towards Mycobacterium as compared to other organisms. According to phytochemical analysis, A. marina had almost all bioactive principles (phytochemicals) except saponins and S. portulacastrum contained all phytochemicals. GC-MS analysis of A.marina also showed the presence of bioactive principles.
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