Relationships between human serum C reactive protein, glucose concentration and insulin sensitivity in obese or overweight women
Paper Details
Relationships between human serum C reactive protein, glucose concentration and insulin sensitivity in obese or overweight women
Abstract
C-reactive protein (CRP) as an inflammatory marker is known to be a risk marker associated with cardiovascular diseases. In this study, relationship between serum CRP with glucose and insulin sensitivity were determined in obese or overweight women. For this purpose, fasting blood samples were collected in 21 sedentary healthy obese or overweight women (age, 39 ± 5.3 year; BMI, 32 ± 3.7 kg/m2) in order to measuring serum CRP, insulin and glucose concentration. Insulin sensitivity was calculated using insulin and glucose. Pearson’s correlations were performed to identify possible relationship among the assessed variables. A positive association was observed between fasting glucose and serum CRP (p = 0.027, r = 0.48). There were no correlations between serum CRP concentrations with insulin (p = 0.881, r = 0.035) or insulin sensitivity (p = 0.821, r = 0.053). Our findings indicate that circulating CRP can be affect glucose concentration independent of insulin sensitivity in obese or overweight subjects.
Bruun JM, Lihn AS, Verdich C, Pedersen SB, Toubro S, Astrup A, Richelsen B. 2003. Regulation of adiponectin by adipose tissue-derived cytokines: in vivo and in vitro investigations in humans. American Journal of Physiology – Endocrinology and Metabolism 285, 527–33.
Ceddia RB, Somwar R, Maida A, Fang X, Bikopoulos G, Sweeney G. 2005. Globular adiponectin increases GLUT4 translocation and glucose uptake but reduces glycogen synthesis in rat skeletal muscle cells. Diabetologia 48(1), 132-9.
Chandalia M, Abate N, Gerg A, Stray-Gunderson J, Grundy SM. 1999. Relationship between generalized and upper body obesity to insulin resistance in Asian Indian Men. Journal of Clinical Endocrinology & Metabolism 84, 2329-2335.
Choi J, Joseph L, Pilote L. 2013. Obesity and C-reactive protein in various populations: a systematic review and meta-analysis. Obesity Reviews 14(3), 232-44.
Deveci E, Yesil M, Akinci B, Yesil S, Postaci N, Arikan E, Koseoglu M. 2009. Evaluation of insulin resistance in normoglycemic patients with coronary artery disease. Clinical Cardiology 32, 32-36.
Festa A, D’Agostino RJR, Howard G, Mykkanen L, Tracy RP, Haffner SM. 2000. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102, 42-47.
Frohlich M, Imhof A, Berg G. 2003. Association between C-reactive protein and features of themetabolic syndrome: a population-based study. Diabetes Care 23, 1835-1839.
Hak AE, Stehouwer CD, Bots ML, Polderman KH, Schalkwijk CG, Westendorp IC, Hofman A, Witteman JC. 1999. Associations of CRP with Measures of Obesity, Insulin Resistance, and Subclinical Atherosclerosis in Healthy, Middle-Aged Women. Arterioscler Thrombosis Vascular Biology 19(8), 1986-91.
Hotamisligil GS. 2006. Inflammation and metabolic disorders. Nature 444, 860–867.
Kantartzis K, Rittig K, Balletshofer B, Machann J, Schick F, Porubska K . 2006. The Relationships of Plasma Adiponectin with a Favorable Lipid Profile, Decreased Inflammation, and Less Ectopic Fat Accumulation Depend on Adiposity. Clin Chem 52(10), 1934-42.
Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. 2000. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. Journal of Clinical Endocrinology & Metabolism 85(7), 2402-10.
Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J. 2007. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circulation Research 100, 1589– 1596.
King DE, Mainous AG III, Egan BM, Woolson RF, Geesey ME. 2005. Fiber and C-reactive protein in diabetes, hypertension and obesity. Diabetes Care 28, 1487–9.
Laaksonen DE, Niskanen L, Nyyssönen K. 2004. C-reactive protein and the development of the metabolic síndrome and diabetes in middle-aged men. Diabetologia 47, 1403-10.
Lindgarde F, Ercilla MB, Correa LR, Ahren B. 2004. Body adiposity, insulin, and leptin in subgroups of Peruvian Amerindians. High Altitude Medicine & Biology 5, 27-31.
Mahadik SR, Deo SS, Mehatalia SD. 2007. Increased prevalence of metabolic syndrome in non-obese Asian Indian: An Urban-Rural comparison. Metabolic Syndrome and Related Disorders 5, 142-152.
Nakanishi N, Shiraishi T, Wada M. 2005. Association between C-reactive protein and insulin resistance in a Japanese population: the Minoh Study. Internal Medicine 44, 542-547.
Ndumele CE, Pradhan AD, Ridker PM. 2006. Interrelationships between inflammation, C-reactive protein, and insulin resistance. Journal of Cardiometabolism Syndrome 1, 190-196.
Panagiotakos DB, Pitsavos C, Chrysohoou C, Skoumas E, Stefanadis C. 2008. Five-year incidence of cardiovascular disease and its predictors in Greece: the ATTICA study. Vascular Medicine 13, 113–21.
Panagiotakos DB, Pitsavos C, Yannakoulia M, Chrysohoou C, Stefanadis C. 2005. The implication of obesity and central fat on markers of chronic inflammation: The ATTICA study. Atherosclerosis, 183(2), 308-15.
Pearson TA, Mensah GA, Alexander RW. 2003. Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation 107, 499-511.
Plaisance EP, Grandjean PW, Judd RL, Jones KW, Taylor JK. 2009. The influence of sex, body composition, and nonesterified fatty acids on serum adipokine concentrations. Metabolism 58(11), 1557-63.
Pradhan AD, Cook NR, Buring JE. 2003. C-reactive protein is independently associated with fasting insulin in nondiabetic women. Arteriosclerosis, Thrombosis, and Vascular Biology 23, 650-5.
Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. 2001. C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. Journal of the American Medical Association 286, 327-334.
Ridker PM. 2007. C-reactive protein and the prediction of cardiovascular events among those at intermediate risk: moving an inflammatory hypothesis toward consensus. Journal of the American College of Cardiology 49, 2129-2138.
Shoelson SE, Herrero L, Naaz A. 2007. Obesity, inflammation, and insulin resistance. Gastroenteritis 132, 2169–2180.
Sujata RM Sudha SD, Suresh DM. 2010. Role of adipocytokines in insulin resistance: Studies from Urban Western Indian Population. International Journal of Diabetes and Metabolism 18, 35-42.
Wexler DJ, Hu FB, Manson JE. 2005. Mediating effects of inflammatory biomarkers on insulin resistance associated with obesity. Obesity Research 13, 1772-3.
Zahedmanesh Forouzan, Pishkar Leila, Yousefi Soheila, Asadi Fatemeh, 2014. Relationships between human serum C reactive protein, glucose concentration and insulin sensitivity in obese or overweight women. J. Biodiv. Environ. Sci., 4(1), 256-261.
Copyright © 2014 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.