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Drug resistance mechanism and therapeutic strategies in Mycobacterium abscessus

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Research Paper 06/10/2024
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Drug resistance mechanism and therapeutic strategies in Mycobacterium abscessus

Debobrata Sharma, Yeasin Arafat, Promi Dewan, M.M. Sultan Mahmud, Shamim Ahmed, Md Motaher Hossain, Md Abdulla Al Jubayed, B. M. Mahmudul Hasan
Int. J. Biosci.25( 4), 96-104, October 2024.
Certificate: IJB 2024 [Generate Certificate]
Key: AntibioticsInfectionsMechanismsMycobacterium abscessusResistanceTherapeutic

Abstract

Considering its resistance mechanisms, Mycobacterium abscessus (Mab) is a major threat to current therapeutic techniques since it is one of the primary causes of serious respiratory infections in immunocompromised persons. The chemotherapeutic choices for infections triggered by Mycobacterium abscessus have become scarce due to its innate and acquired resistance to regularly administered antibiotics. Therefore, for efficient therapy, it is imperative to understand both intrinsic and acquired resistant to antibiotics in Mab. In this current review, we provide recent updates on the mechanisms of both intrinsic and acquired resistant to antibiotics and treatment efficacy in Mab. Thus, a thorough comprehension of the mechanisms underlying drug resistance and the therapeutic effectiveness of antibiotics against Mab can yield novel suggestions for enhancing treatment results, lowering mortality, averting drug resistance, and stopping Mab transmission. Furthermore, it will aid in the development of new antibiotics for Mab as well as quick molecular diagnostic tools.

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