Effect of aqueous leaf extract of Senna occidentalis (Fabaceae) on induced arrhythmia in Rabbits
Paper Details
Effect of aqueous leaf extract of Senna occidentalis (Fabaceae) on induced arrhythmia in Rabbits
Abstract
Côte d’Ivoire, the leaves of Senna occidentalis (Fabaceae) are widely used to treat palpitations and chest pain. Cardiac arrhythmias are considered a serious pathology and present more frequently in the elderly. The aim of this study was to evaluate the antiarrhythmic effect of an aqueous extract of Senna occidentalis (EASo) leaves (Fabaceae) in rabbits. Phytochemical screening is carried out to highlight the major chemical groups. The armpits of the two forelimbs and the groins of the two hind limbs of anaesthetized rabbits are shaved and cleaned with alcohol, then induced with a conductive gel. Four electrodes are attached to the armpits and groin respectively. The electrodes attached to the animal are each connected to the cable corresponding to the appropriate limb, and the various cardiogram parameters: speed (25 mm/s), leads, filter and amplification are set. Phytochemical screening showed the presence of sterols, polyterpenes, polyphenols, saponosides, quinone compounds, alkaloids and gall tannins. In the present study, dose-responses ranging from 10-3, 5.10-3, 5.10-2 and 10-1 mg/kg bw had no significant effect on heart rate. On the other hand, KCl, at a dose of 10-3 mg/kg bw, causes a cardiac arrhythmia which is regulated to normal by a dose of 10-2mg/kg bw of EASo. Thus, KCl has no effect on the ECG of EASo-pretreated rabbits. The effect of EASo on the ECG in rabbits can be attributed to the secondary metabolists it contains, which justifies the use of Senna occidentalis (Fabaceae) in traditional medicine against cardiac pathologies.
Abo KJC. 2013. De la plante à la molécule: Toxicité, effets pharmacologiques et mécanisme d’action de Justicia secunda (Acanthaceae), plante antihypertensive, sur le système cardiovasculaire de mammifères. Thèse de Doctorat d’État ès Sciences Naturelles, Université Félix Houphouët-Boigny, Abidjan, Côte d’Ivoire. n° 752/2013, 351p.
Aka KJ. 1980. Analyse de la repolarisation du myocarde ventriculaire du singe en relation avec la fibrillation cardiaque: Influence d’une substance cardioactive africaine (extrait de Mansonia altissima). Thèse de Doctorat d’État ès Sciences, Université d’Abidjan. n° 55, 233p.
Ake-Assi L. 1984. La flore de Côte d’Ivoire: Étude descriptive et biogéographique avec quelques notes ethnologiques. Thèse de Doctorat d’État, Faculté des Sciences et Technologie, Université Cocody Abidjan, Côte d’Ivoire 84, 607–617.
Bouquet A, Debray M. 1974. Plantes médicinales de la Côte d’Ivoire. Paris: ORSTOM. Travaux et Document de l’ORSTOM 32, 75–76.
Cazaux-Lerou F. 2016. Sécurité et tolérance des anticoagulants oraux directs dans une population de fibrillation auriculaire: Étude prospective monocentrique. Thèse de Médecine, Université de Bordeaux. 213p.
Ehile EE, Ouedraogo L, Aka KJ. 1990. Effet inotrope positif d’un extrait aqueux de Mansonia altissima sur le duodénum isolé de lapin. Bulletin Médical et Pharmaceutique 4(1), 3–15.
Enejeo AS, Egwari LOAA, Mosaku TO. 2011. In vitro antimicrobial screening on Anchomas difformis (Blume) Engl leaves and rhizomes against select pathogens of public health importance. Advances in Biological Research 4, 221–225.
Itsuo K, Kayazuyasu M, Ryoko S, Haruos H, Jungji T. 1996. Electropharmacology of Ro22-9194, a new antiarrhythmic agent. General Pharmacology 27(5), 755–760.
Keating MT, Sanguinetti MC. 2001. Molecular and cellular mechanisms of cardiac arrhythmias. Cell 104, 569–580.
Kerharo J. 1980. Les relations de l’alimentation avec la médecine et la pharmacopée traditionnelles en Afrique noire. Présence africaine, 96–121.
Lazureski GV, Terenteva IV, Chamchurin AA. 2007. Praticheskii raboti po khimii soedinienii. Vischaya Chkola, Moscou, Russie. 334p.
Lee KHJ. 2004. Current development in discovery and design of new drug candidates from plant natural product leads. Journal of Natural Products 67, 273–283.
Mea A, Ekissi YHR, Abo KJC, Kahou BGP. 2017. Hypoglycaemiant and antihyperglycaemiant effect of Justicia secunda M. Vahl (Acanthaceae) on glycaemia in the Wistar rat. International Journal of Development Research 7(06), 131–178.
Tonye Mahop M, Mayet M. 2007. Ethnobotanical research on anti-diabetic medicinal plants in the Eastern Cape Province, South Africa. African Journal of Biotechnology 6(25), 2945–2952.
Vassort G, Rougier O. 1972. Membrane potential and slow inward current dependence of frog cardiac mechanical activity. Pflügers Archiv 331, 191–203.
Obrou Jean Luc Amiltone, Nagalo Ousmane, Mossoun Mossoun Arsène, Abo Kouakou Jean-Claude, 2025. Effect of aqueous leaf extract of Senna occidentalis (Fabaceae) on induced arrhythmia in Rabbits. Int. J. Biosci., 27(5), 198-203.
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