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A STEP FORWARD TOWARDS COMBINATION THERAPY FOR THE PREVENTION OF HCV

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Research Paper 01/01/2020
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A STEP FORWARD TOWARDS COMBINATION THERAPY FOR THE PREVENTION OF HCV

Jabir Ali, Syed Saad Ul Hassan Bukhari, Kinza Tanvir, Ujalla Tanveer, Maheen Shafiq, Juon Abbass, Iqra Mumtaz, Zoha Naeem, Sajid Ali, Mubbara Tariq
Int. J. Biosci.16( 1), 68-82, January 2020.
Certificate: IJB 2020 [Generate Certificate]
Key: AnemiaBias RiskCirrhosisCombination TherapyNS5A inhibitor

Abstract

Chronic hepatitis C is very common condition prevailing worldwide. In Pakistan, its prevalence is about 5.9%. Now, there is no vaccine available for HCV prophylaxis, so focus must be toward the treatment of HCV through combination therapy. Combination of peg-interferon alpha and ribavirin exhibits strong potential for treating Hepatitis C and at present, reported as standard treatment. Patients infected with genotype 1 and do not have any previous HCV treatment are subjected to 8 week course of treatment with ledipasvir and sofobuvir so; the treatment is limited according to fibrosis stage and baseline viral load. Ribavirin free regimens-oral interferon and elbasvir-grazoprevir are presenting as a new therapeutic treatment for HCV. End point of this therapy is sustained virological response which is aviremia condition developed after 24 weeks of therapy however, end treatment response is a condition after completion of therapy. The main goal of anti-HCV combination therapy is to eliminate HCV infection and complications associated with extrahepatic tissues and liver diseases including cirrhosis, fibrosis, hepatocellular cancer and death.

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