The Nickel nanoparticles induced renal pathophysiological and histopathological alterations in male sprague dawley rats
Paper Details
The Nickel nanoparticles induced renal pathophysiological and histopathological alterations in male sprague dawley rats
Abstract
Owing to nickel nanoparticles (Ni NPs) extensive utilizations in various industries, its toxic effects might not be neglected. The recent study considered Ni NPs induced renal physiological and histological alterations in male Sprague Dawley rats. The present study involved 20 rats and randomly divided into four groups (n=5 per group) included control group (C) and treated groups [low dose (N-G1), medium dose (N-G2), high dose (N-G3)]. The rats of treated groups intraperitoneally (i.p) injected with Ni NPs doses either 15mg/kg or 30mg/kg or 45mg/kg for 28 days on alternate day. The rats were sacrificed at 29th day and the samples were collected for subsequent biochemical analyses included hematological analysis, renal function test and histopathology. The results of hematological analysis revealed dose dependent reduction of RBCs and HB. Meanwhile, significant reduction of following RBCs parameters were observed such as MCH, MCV, MCHC, and HTC than control (P< 0.05). The results also depicted that the accumulation of Ni NPs caused inflammation and turned on autoimmune system which increased PLTs and WBCs production included granulocyte, monocyte and lymphocyte in treated groups than control (P<0.05). The kidney function test of treated rats showed significant production of renal biomarkers (BUN, uric acid and creatinine) in dose dependent manner which induced various histopathologies included necrosis (NIC), cloudy swelling (CS), vascular dilation (VD), and pycnotic nuclei (PN) while the ordinal scoring showed dose dependent severity of histopathologies. So, the study suggested the dose dependent response in renal pathophysiologies and histopathologies due to Ni NPs exposure.
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