Protective effect of Pistacia integerrima galls in nimesulide induced acute hepatorenal toxicity
Paper Details
Protective effect of Pistacia integerrima galls in nimesulide induced acute hepatorenal toxicity
Abstract
Herbal medicines have a long history of use in the management of different diseases owing to economy and relatively with few or no adverse effects. Due to the presence of antioxidant potential, Pistacia integerrima has been used for various health problems. The objective of the current study was to assess the protective role of the methanolic extract of Pistacia integerrima galls at different doses, in the acute toxicity of nimesulide on hepatorenal function. A filtered and dried methanolic (99.8%) extract of galls of Pistacia Integerrima was obtained. Rabbits were used as animal model for this study. Vitamin-C and silymarin were used as standard drugs. The result showed that nimesulide at 15mg/kg/day dose elevated the ALT level of liver within seven days of administration as compared to normal group (p˂0.05). Among all the groups, administered with methanolic extract of Pistacia integerrima galls at different doses (100, 300 and 500mg/kg/day respectively), the group at a dose of 300mg/kg/day, have shown some protective effect in the hepatotoxicity as compared to silymarin (control group) p˂0.05. The renal function is affected insignificantly in the acute toxicity induced by nimesulide at 15mg/kg/day as compared to normal and other groups (p˃0.05). A moderate increase was observed in the level of TLC in nimesulide-only group as compared to normal. It shows that Pistacia Integerrima galls possess potential of reversing the toxic effect, induced by nimesulide with respect to hepatic and renal functions.
Agúndez JA, Lucena MI, Martínez C, Andrade RJ, Blanca M, Ayuso P, García-Martín E. 2011. Assessment of nonsteroidal anti-inflammatory drug-induced hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 7(7), 817-828.
Ahmad NS, Waheed A, Farman M, Qayyum A. 2010. Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice. Journal of Ethnopharmacology 129(2), 250-253.
Boelsterli UA. 2002a. Nimesulide and hepatic adverse effects: roles of reactive metabolites and host factors. International Journal of Clinical Practice. Supplement (128), 30-36.
Boelsterli UA. 2002b. Mechanisms of NSAID-induced hepatotoxicity. Drug Safety 25(9), 633-648.
Bort R, Ponsoda X, Jover R, Gómez-Lechón MJ, Castell JV. 1999. Diclofenac toxicity to hepatocytes: a role for drug metabolism in cell toxicity. Journal of Pharmacology and Experimental Therapeutics 288(1), 65-72.
Cantoni L, Valaperta R, Ponsoda X, Castell JV, Barelli D, Rizzardini M. 2003. Induction of hepatic heme oxygenase-1 by diclofenac in rodents: role of oxidative stress and cytochrome P-450 activity. Journal of Hepatology 38 (6), 776-783.
Chatterjee M, Sil PC. 2007. Protective role of Phyllanthus niruri against nimesulide induced hepatic damage. Indian Journal Clinical Biochemistry 22(1), 109-116.
Cragg GM, Newman DJ. 2001. Natural product drug discovery in the next millennium. Pharmaceutical Biology 39 (1), 8-17.
Famaey J. 1997. In vitro and in vivo pharmacological evidence of selective cyclooxygenase-2 inhibition by nimesulide: an overview. Inflammation Research 46(11), 437-446.
Janakat S, AL-Merie H. 2002. Evaluation of hepatoprotective effect of Pistacia lentiscus, Phillyrea latifolia and Nicotiana glauca. Journal of Ethnopharmacology 83(1), 135-138.
Joshi UPA, M SH. 2010. In Vitro Antioxidant and Hepatoprotective Activity of Isolated Compounds from Pistacia Integerrima Australian Journal of Medical Herbalism 22(3), 94-99.
Mahmood KAS, Ahmed JH, Jawad AM. 2009. Non-steroidal anti-inflammatory drugs (NSAIDs), free radicals and reactive oxygen species (ros): a review of literature. The medical journal of Basrah University 27(1), 46-53.
Maryam S, Bhatti ASA, Shahzad AW. 2010. Protective effects of silymarin in isoniazid induced hepatotoxicity in rabbits. Annals of King Edward Medical University 16(1), 43-47.
Masubuchi Y, Yamada S, Horie T. 2000. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. Journal of Pharmacology and Experimental Therapeutics 292(3), 982-987.
Merlani G, Fox M, Oehen HP, Cathomas G, Renner EL, Fattinger K et al. 2001. Fatal hepatotoxicity secondary to nimesulide. European Journal of Clinical Pharmacology 57(4), 321-326.
Nair P, Kanwar SS, Sanyal SN. 2006. Effects of non steroidal anti-inflammatory drugs on the antioxidant defense system and the membrane functions in the rat intestine. Nutricion hospitalaria 21(6), 638-649.
Nguyen V, Huang J, Doan V, Lin X, Tang X, Huang Y, et al. 2015. Hepatoprotective effects of Yulangsan polysaccharide against nimesulide-induced liver injury in mice. Journal of Ethnopharmacology 172, 273-280.
Patel PB, Patel TK, Patni S, Baxi SN, Shrma HO, Tripathi CB. 2011. Hepatotoxicity Studies of Nimesulide in litters of rat. National Journal of Integrated Research in Medicine 2(1), 16-21.
Raafat BM, Shafaa MW, Rizk RA, Elgohary AA, Saleh A. 2009. Ameliorating effects of vitamin C against acute lead toxicity in albino rabbits. Australian Journal of Basic and Applied Science 3(4), 3597-3608.
Rodrigo L, Francisco RD, Pérez-Pariente J, Cadahia V, Tojo R, Rodriguez M, et al. 2002. Nimesulide-induced severe hemolytic anemia and acute liver failure leading to liver transplantation. Scandinavian Journal of Gastroenterology 37(11), 1341-1343.
Savithramma N, Raoml Suhrulatha D. 2011. Screening of medicinal plants for secondary metabolites. Middle-East Journal of Scientific Research 8(3), 579-584.
Siddiqi A, Alam SS, Begum S, Nazneen Z, Aaqil B, Alam MA. 2015. Evaluation of Therapeutic Potential of Picrurhiza Kurroa Glycosidal Extract against Nimesulide Nephrotoxicity: A Pilot Study. J Ayub Med Coll Abbottabad 27(2), 312-3.
Singh BK, Tripathi M, Chaudhari BP, Pandey PK, Kakkar P. 2012. Natural terpenes prevent mitochondrial dysfunction, oxidative stress and release of apoptotic proteins during nimesulide-hepatotoxicity in rats. PLoS One 7, e34200.
Singla AK, Chawla M, Singh A. 2000. Review nimesulide: some pharmaceutical and pharmacological aspects—an update. Journal of Pharmacy and Pharmacology 52(5), 467-486
Tan H, Ong W, Lai S, Chow W. 2007. Nimesulide-induced hepatotoxicity and fatal hepatic failure. Singapore Medical Journal 48(6), 582-585.
Tripathi M, Singh BK, Mishra C, Raisuddin S, Kakkar P. 2010. Involvement of mitochondria mediated pathways in hepatoprotection conferred by Fumaria parviflora Lam. extract against nimesulide induced apoptosis in vitro. Toxicology in Vitro 2(4), 495-508.
Van Steenbergen W, Peeters P, De Bondt J, Staessen D, Büscher H, Laporta T, et al. 1998. Nimesulide-induced acute hepatitis: evidence from six cases. Journal of Hepatology 29(1), 135-141.
Walker SL, Kennedy F, Niamh N, McCormick PA. 2008. Nimesulide associated fulminant hepatic failure. Pharmacoepidemiology and Drug Safety 17(11), 1108-1112.
Wallace JL, Granger DN. 1992. Pathogenesis of NSAID gastropathy: are neutrophils the culprits? Trends in Pharmacological sciences 13(4), 129-131.
Weiss P, Mouallem M, Bruck R, Hassin D, Tanay A, Brickman CM, et al. 1999. Nimesulide-induced hepatitis and acute liver failure. The Israel Medical Association journal 1(2), 89-91.
Xu JJ, Henstock PV, Dunn MC, Smith AR, Chabot JR, de Graaf D. 2008. Cellular imaging predictions of clinical drug-induced liver injury. Toxicological Sciences 105(1), 97-105.
Saeed Ahmad, Mir Azam Khan, Haji Bahadar, Abdullah, Muhammad Umar Farooq, 2019. Protective effect of Pistacia integerrima galls in nimesulide induced acute hepatorenal toxicity. Int. J. Biosci., 15(2), 612-622.
Copyright © 2019 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.