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A review on advancement towards hepatitis c virus genotyping and novel assays approach for determination of HCV Genotypes

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Review Paper 01/12/2019
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A review on advancement towards hepatitis c virus genotyping and novel assays approach for determination of HCV Genotypes

Hafiz Muhammad Imran, Bahzad Ahmad Farhan, Sidra Akram, Mubara Saeed, Kainat Anwer, Amina Sehar, Maryam Aslam, Asfoora Azmat, Muhammad Zulqarnain Haider
Int. J. Biosci.15( 6), 420-440, December 2019.
Certificate: IJB 2019 [Generate Certificate]
Key: 9G testHCV GenotypesNucleotide sequencingSentosa SQVersant Assay

Abstract

HCV is an epidemic pathogen worldwide and thousands of people die each year by infectious effects of HCV which is ultimately effect liver and damage liver functioning by liver cirrhosis. Currently, vaccine for HCV is not developed due to its 6 major genotypes and more than 67 subtypes. Therefore, for each viral genotype treatment is different. HCV is globally distributed in the world. Thus, each viral genotypes and subtypes are widespread in the particular areas of world. In Pakistan, the most prevalent subtype of HCV is 3a. There is a great challenge for identification of type of viral genotype in each patient for proper treatment of viral infection. Therefore, different types of assays are used for determination of type of viral infection. Nucleotide sequencing method for genotype and subtype determination is an appropriate method for diagnosis which require sequencing of whole genome of HCV, but this method is more expensive and time consuming. Versant assay or Line Probe assay (LiPA), Sentosa SQ HCV genotyping assay, HCV genotyping 9G test and Cobas HCV genotyping are appropriate and less time-consuming method of screening of HCV genotyping and can be suitable and can meet whole requirements of identification of type of viral infection.

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