home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

A study of high-sensitivity C-reactive protein in relation to respiratory symptoms in mild to moderate asthma

Paper Details

Research Paper 01/10/2011
Views (344) Download (7)
current_issue_feature_image
publication_file

A study of high-sensitivity C-reactive protein in relation to respiratory symptoms in mild to moderate asthma

Mojtaba Izadi, Somayeh Bakhshi, Payman Abrifam, Davood Khorshidi
Int. J. Biosci.1( 5), 83-88, October 2011.
Certificate: IJB 2011 [Generate Certificate]
Key: AsthmaC-reactive proteinInflammationSpirometry

Abstract

To determine the role high-sensitivity C-reactive protein (CRP) as a inflammation cytokine in the severity of asthma, a resting spirometry test and fasting blood sampling was performed in 42 middle-aged males with mild to moderate severity of asthma for measuring serum CRP and respiratory functional. Also, a total 33 healthy males participated in study as control group. Pearson correlations were used to establish the relationship between serum CRP concentrations with spirometry markers in asthma patients. Serum CRP concentration in asthmatic patients was significantly higher than healthy subjects. Serum CRP correlated negatively with FEV1 (p = 0.021), FVC (p = 0.026) and FEV1/FVC (p = 0.034). Based on our results, we can say asthma is a inflammation disorder and these date support the hypothesis that the measurement of serum levels of hs-CRP may be useful tool for detecting systemic inflammation in asthma.

VIEWS 4
Cover PDF

Amina H, Abdul G, Abdul K, Jasim M .2010.Association Between C Reactive Protein and Asthma. TurkishTorax Dergisi 11(3). 098 -104.

Aronson D, Roterman I, Yigla M, Kerner A, Avizohar O, Sella R. 2006. Inverse association between pulmonary function and C-reactive protein in apparently healthy subjects. American journal of respiratory and critical care medicine’s 174(6), 626-32.

de Torres JP, Cordoba-Lanus E, Lo ´pez-Aguilar C. 2006. C-reactive protein levels and clinically important predictive outcomes in stable COPD patients. European Respiratory  Journal  27(5). 902-7.

Ebrahim R, Hassan E, Hossein A, Vajihe C, Armin R. 2011. Armin Razi Evaluation of High-Sensitivity C-Reactive Protein in Acute Asthma Tanaffos 11(1). 32-37.

Ford ES. 2003. Asthma, body mass index, and C-reactive protein among US adults. Journal of Asthma 40 (7). 733- 9.

Fujita M, Ueki S, Ito W, Chiba T, Takeda M, Saito N, et al. 2007. C-reactive protein levels in the serum of asthmatic patients. Annals of Allergy, Asthma and Immunology 99(1), 48- 53.

Georas SN, Guo J, De Fanis U, Casolaro V. 2005. T-helper cell type-2 regulation in allergic disease. European Respiratory Journal 26(6), 1119-1137.

Jousilahti P, Salomaa V, Hakala K, Rasi V, Vantera E, Palosuo T. 2002. The association of sensitive inflammation markers with bronchial asthma. Annals of Allergy, Asthma and Immunology 89(4). 381-5.

Kishimoto T. 2005. Interleukin-6: from basic science to medicine-40 years in immunology. Annual Review of Immunology 23(2). 1-21.

Kony  S,  Zureik  M,  Driss  F,  Neukirch  C, Leynaert  B, Neukirch F. 2004. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax 59(10). 892-6.

Mannino DM, Ford ES, Redd SC. 2003. Obstructive and restrictive lung disease and markers of inflammation: data from the Third National Health and Nutrition Examination. American Journal of Medicine 114(9), 758-762.

Marchi A, Ricci A. 2002. Management of the asthmatic adolescent. Minerva Pediatr 54(6), 587-97.

Olafsdottir IS, Gislason T, Thjodleifsson B, Olafsson I, Gislason D, Jِgi R. 2005. C reactive protein levels are increased in nonallergic but not allergic asthma: a multicentre epidemiological study. Thorax 60(6), 451- 4.

Pepys  MB,  Hirshfield  GM. 2003. C-reactive protein: a critical update. Journal of Clinical Investigation 111(12), 1805-12.

Ramirez D, Patel P, Casillas A, Cotelingam J,  Boggs P, Bahna SL. 2010. Assessment of high-sensitivity C-reactive protein as a marker of airway inflammation in asthma. Annals of Allergy, Asthma and Immunology 104(6), 485- 9.

Sahoo RC, Acharya PR, Noushad TH, Anand R, Acharya VK, Sahu KR. 2009. A Study of High-Sensitivity C-Reactive Protein in Bronchial Asthma.Indian journal of chest diseases & allied sciences 51(4), 213-6.

Sنvykoski T, Harju T, Paldanius M, Kuitunen H, Bloigu A, Wahlstrِ m E. 2004. Chlamydia pneumoniae infection and inflammation in adults with asthma. Respiration 71(2), 120- 5.

Schroeder EB, Welch VL, Couper D, Nieto FJ, Liao D, Rosamond WD. 2003. Lung function and incident coronary heart disease: the Atherosclerosis Risk in Communities Study. American Journal of Epidemiology 158(12), 1171-1181.

Sin DD, Lacy P, York E, Man SF. 2004. Effects of fluticasone on systemic markers of inflammation in chronic obstructive pulmonary disease. American journal of respiratory and critical care medicine’s 170(7), 760-765.

Sin DD, Man SF. 2003. Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease. Circulation 107(11), 1514-1519.

Sin DD, Wu L, Man SF. 2005. The relationship between reduced lung function and cardiovascular mortality: a population-based study and a systematic review of the literature. Chest 127(6): 1952-1959.

Takemura M, Matsumoto H, Niimi A, Ueda T, Matsuoka H, Yamaguchi M. 2006. High sensitivity C-reactive protein in asthma. European Respiratory Journal 27(5), 908- 12.

Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. 1999. Elevated C-reactive protein levels in overweight and obese adults. Journal of the American Medical Association 282(22), 2131- 5.

Yudkin JS, Stehouwer CD, Emeis JJ, Coppack SW. 1999. C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction: a potential role for cytokines originating from adipose tissue? Arteriosclerosis, Thrombosis, and Vascular Biology 19(4), 972- 8.

Submit Manuscript