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Accuracy of cervico vaginal fetal fibronectin test in predicting risk of spontaneous preterm birth

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Research Paper 01/07/2019
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Accuracy of cervico vaginal fetal fibronectin test in predicting risk of spontaneous preterm birth

Maysoon Sharief, Saha Mahmood
Int. J. Biomol. & Biomed.10( 1), 1-6, July 2019.
Certificate: IJBB 2019 [Generate Certificate]
Key: Cervico vaginalFetal fibronectinPregnancyPreterm birth

Abstract

Preterm delivery is the leading cause of neonatal mortality. One of the best predictors to assess the risk of preterm labour (PTB) is by measuring fetal fibronectin (fFN) in cervico vaginal secretion after 26 weeks of pregnancy. The aim is to evaluate the diagnostic accuracy of qualitative cervico vaginal fFN in symptomatic women and asymptomatic high risk women during antenatal care. Prospective study which was conducted in Basrah Maternity and Child Hospital. It included 106 pregnant women at gestational age more than 26 weeks who had uterine contraction with or without pervious risk factors for PTB. Cervico vaginal fluid sampling was undertaken from all women included in the study after the age of 26 weeks of gestation and qualitative fFN assessment was done with 50ng/ml is the cut off point for positivity. As regard qualitative fFN assessment for predicting of PTB sensitivity, specificity, PPV, NPV, were 71%, 87%, 40.50%, 94% respectively in symptomatic women. While in asymptomatic women with previous high risk had 26% sensitivity, 84% specificity, 32% PPV, and 87% NPV. Qualitative assessment of fFN in cervico vaginal fluid is good predictive marker in detecting of PTB.

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