Acylated ghrelin in response to short time exercise in middle-aged men

Paper Details

Research Paper 01/01/2013
Views (416) Download (9)
current_issue_feature_image
publication_file

Acylated ghrelin in response to short time exercise in middle-aged men

Eizadi M, Dooaly H, Kiani F, Khorshidi F
Int. J. Biosci.3( 1), 164-169, January 2013.
Certificate: IJB 2013 [Generate Certificate]

Abstract

Ghrelin, a 28-amino-acid peptide, reduces fat oxidation and increases adiposity and its dysregulation may be important in obesity. This study aims to clarify the effects of a single bout exercise on levels of Acylated ghrelin and insulin resistance in Seventeen healthy sedentary obese men (39 ± 5 years mean ± standard deviation of mean, BMI ≥ 30 kg/m2). For this purpose, pre and post-exercise blood samples were collected to measuring ghrelin, insulin and glucose concentration. Insulin resistance was assessed using the homeostasis model assessment for insulin resistance formula derived from insulin and glucose levels. Student’s t-tests for paired samples used to determine whether there were significant changes in each of variables in response to exercise test. Compared to pre-exercise, serum ghrelin increased significantly after exercise (p = 0.009). Serum insulin and insulin resistance did not change after exercise test when compared to pre-test. Based on these data, we conclude on session short-time exercise can be increase serum Ghrelin even in obese subjects.

VIEWS 11

Barazzoni R, Zanetti M, Ferreira C. 2007. Relationships between desacylated and acylated ghrelin and insulin sensitivity in the metabolic syndrome,” Journal of Clinical Endocrinology and Metabolism 92, 3935–3940.

Broglio F, Benso A, Castiglioni C. 2003. The endocrine response to ghrelin as a function of gender in humans in young and elderly subjects. J Clin Endocrinol Metab 88, 1537-42.

Cris A. Charles J, Lori A, Michael T, Kim M, Joseph A. 2009. Effects of Exercise Training Intensity on Pancreatic B-Cell Function. Diabetes care 32(10), 1807-1811.

Dezaki K, Hosoda H, Kakei M. 2004. Endogenous ghrelin in pancreatic islets restricts insulin release by attenuating Ca2+ signaling in ß-cells: implication in the glycemic control in rodents. Diabetes 53, 3142-51.

Duncan M, Singh B, Wise P. 1995. A simple measure of insulin resistance. Lancet 346, 120–1.

Eizadi M, Khorshidi D, Seyedhoseini MA, Daraei Shokrabad F. 2011. Aerobic Exercise-Induced Weight Reduction Decrease Serum Leptin in Patients with Diabetic Mellitus. Advance in bioresearch 2(2), 143-150.

Erdmann J, Tahbaz R, Lippl F, Wagenpfeil S, Schusdziarra V. 2007. Plasma ghrelin levels during exercise – effects of intensity and duration. Regul Pept 143(1-3), 127-35.

Ghanbari-Niaki A. 2006. Ghrelin and glucoregulatory hormone responses to a single circuit resistance exercise in male college students. Clin Biochem 39(10), 966-70.

Hagobian TA, Sharoff CG, Braun B. 2008. Effects of short-term exercise and energy surplus on hormones related to regulation of energy balance. Metabolism 57(3), 393-8.

Houmard JA, Tanner CJ, Slentz CA. 2004. Effect of the volume and intensity of exercise training on insulin sensitivity. J Appl Physiol 96, 101–106.

Hughes VA, Fiatarone MA, Fielding RA. 1993. Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. Am J Physiol 264, 855–862.

Julia W, Karen C, Javier R, Ascension M. 2010. Role of physical activity on immune function Physical activity, exercise and low-grade systemic inflammation. Proceedings of the Nutrition Society 69, 400–406.

Kelishadi R, Hashemipour M, Mohammadifard N, Alikhassy H, Adeli K. 2008. Short- and long-term relationships of serum ghrelin with changes in body composition and the metabolic syndrome in prepubescent obese children following two different weight loss programs. Clin Endocrinol (Oxf). [Epub ahead of print].

Kim HJ, Lee S, Kim TW, Kim HH, Jeon TY, Yoon YS, Oh SW, Kwak H, Lee JG. 2008. Effects of exercise-induced weight loss on acylated and unacylated ghrelin in overweight children. Clin Endocrinol (Oxf) 68(3), 416-22.

Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. 1999. Ghrelin is a growth- hormone-releasing acylated peptide from stomach,” Nature 402(6762), 656–660.

Malkova D, McLaughlin R, Manthou E, Wallace AM, Nimmo MA. 2008. Effect of Moderate-intensity Exercise Session on Preprandial and Postprandial Responses of Circulating Ghrelin and Appetite. Horm Metab Res [Epub ahead of print].

Mullis R, Campbell IT, Wearden AJ, Morriss RK, Pearson DJ. 1999. Prediction of peak oxygen uptake in chronic fatigue syndrome. British Journal of Sports Medicine 33(5), 352-6.

Pulkkinen L, Ukkola O, Kolehmainen M, Uusitupa M. 2010. Ghrelin in Diabetes and Metabolic Syndrome. Int J Pept. 3, 1-11.

Schmidt A, Maier C, Schaller G, Nowotny P, Bayerle-Eder M, Buranyi B, Luger A, Wolzt M. 2004. Acute exercise has no effect on ghrelin plasma concentrations. Horm Metab Res 36(3), 174-7.

Shiiya T, Nakazato M, Mizuta M. 2002. Plasma ghrelin levels in lean and obese humans and the effect of glucose on ghrelin secretion,” Journal of Clinical Endocrinology and Metabolism 87(1), 240–244.

Tsch¨op M, Weyer C, Tataranni PA, Devanarayan V, Ravussin E, HeimanML. 2001. Circulating ghrelin levels are decreased in human obesity,” Diabetes 50(4), 707–709.

Ukkola O, Kunnari A, Jokela M, Päivänsalo M, Kesäniemi YA. 2009. Ghrelin and metabolic disorders. Current Protein and Peptide Science 10 (1), 2–7.

Vivenza D, Rapa A, Castellino N. 2004. Ghrelin gene polymorphisms and ghrelin, insulin, IGF-I, leptin and anthropometric data in children and adolescents,” European Journal of Endocrinology 151(1), 127–133.

Yada T, Dezaki K, Sone H, Koizumi M, Damdindorj B, Nakata M, Kakei M. 2008. Ghrelin regulates insulin release and glycemia: physiological role and therapeutic potential. Curr Diabetes Rev 4(1), 18-23.