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Anti-inflammatory properties of Uvaria chamae used in traditional Beninese medicine (West Africa)

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Research Paper 07/01/2024
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Anti-inflammatory properties of Uvaria chamae used in traditional Beninese medicine (West Africa)

Lauris Fah, Jean Robert Klotoé, Eric Agbodjento, Victorien tamègnon Dougnon, Moïse Glèlè, Kévin Sintondji, Phénix Assogba, Esther Déguénon, Akadiri Yessoufou
J. Bio. Env. Sci.24( 1), 40-50, January 2024.
Certificate: JBES 2024 [Generate Certificate]
Key: Anti-inflammatory activityTNFαUvaria chamae

Abstract

Inflammatory diseases are still a major public health concern. Their management is problematic due to the harmful side-effects of anti-inflammatory drugs traditionally used in conventional medicine. Medicinal plants are a credible source for research into new anti-inflammatory drug. This study aimed to explore the anti-inflammatory properties of the roots of Uvaria chamae. Anti-inflammatory activity was explored using the red blood cell membrane stability test and the formalin-induced œdema model in rats. TNFα assay was used to assess immunomodulatory activity. This methodology was complemented by research into antioxidant power using the DPPH test. Results indicated that the extract significantly inhibited membrane destabilization of red blood cells (61.43%), and the formation of formalin-induced paw œdema. This effect is consistent with the reduced production of TNFα (22.06%). The extract tested proved to be a good antioxidant by inhibiting the DPPH radical (IC50= 0.669 mg/mL); its larvae toxicity was moderate (LC50 = 0.033 mg/mL). These results suggest that the ethanolic extract of U. chamae roots has anti-inflammatory, immunomodulating and antioxidant properties. This justifies the use of the plant in traditional Beninese medicine for the treatment of inflammatory diseases.

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