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Anticancer activity of ethnobotanicals of the Philippine Ilongot-Eǵongot community on human colon cancer cells (HCT-116)

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Research Paper 01/07/2019
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Anticancer activity of ethnobotanicals of the Philippine Ilongot-Eǵongot community on human colon cancer cells (HCT-116)

Earl Jericho DJ. Cachin, Glenn G. Oyong, Khristina G. Judan Cruz
Int. J. Biosci.15( 1), 236-241, July 2019.
Certificate: IJB 2019 [Generate Certificate]
Key: Colon cancerEthnobotanicalsHCT-116Ilongot-eǵongot

Abstract

Globally, colon cancer is one of the leading causes of cancer deaths. Colon carcinoma is one of the best-understood neoplasms from the genetic perspective, yet it remains the second most cause of cancer-related deaths. As one of the developing countries, Philippines possess a rich biodiversity that offers wide range of ethnobotanicals waiting to be utilized for cancer treatment. Ethanolic extracts of ten ethnobotanicals collected from the Ilongot-Eǵongot community of Bayanihan, Maria Aurora, and Aurora, Philippines were tested against human colon cancer cell line HCT-116. Cell viability and cytotoxicity was determined using the PrestoBlue® Assay. The assay revealed that Premna odorata (Local Name: Asedaong; IC50 0.8747 μg/ml), Dillenia philippinensis(Local Name: Katmon; IC50 0.6358 μg/ml), Eleusine indica (Local name: Pag; IC50 0.6653 μg/ml), Mikania micrantha (Local Name: Ola ola; IC50 0.8201 μg/ml), Diplazium esculentum (Local name: Pako Pako; IC50 0.7338 μg/ml), Urena lobata(Local name: Pukot; IC50 1.009 μg/ml), Hydrocotyle vulgaris(Local name: Gotukola; IC50 0.8788 μg/ml), Ceiba pentandra (Local name: Betek; IC50 1.04 μg/ml), Adenanthera intermedia(Local name: Kares; IC50 1.295 μg/ml) and Stachytarpheta sp. (Local Name: Luzviminda; IC50 1.322 μg/ml), showed anticancer activity against human colon cancer cell line (HCT-116). All extracts showed an IC50 <20 µg/mL which is considered as highly toxic.

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