home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Antimicrobial status of salmonella meningitis in Niger

Paper Details

Research Paper 01/08/2017
Views (355) Download (5)
current_issue_feature_image
publication_file

Antimicrobial status of salmonella meningitis in Niger

A. Ali, O. Sani, A. Moumouni, J. Zanguina, A. Soussou, J. Testa, B. H. Halima
Int. J. Micro. Myco.6( 2), 1-6, August 2017.
Certificate: IJMM 2017 [Generate Certificate]
Key: Antimicrobial statusCERMESNigerSalmonella meningitisSurveillance

Abstract

Salmonella meningitis prognosis is poor and the choice of adequate antibiotic therapy is difficult in developing countries where laboratory testing is not accessible. This study aimed to evaluate, the antibiotic susceptibility pattern of salmonella isolated from CSF in meningitis suspected cases and to identify the best drug option. From 2011 to 2015, 6630 CSF collected were sent at CERMES, during laboratory-based surveillance. All turbid and freshly collected CSF from under 5 years patients were subjected to standard bacteriological method for isolation and characterization of meningitis etiologies. A total of 11/6630 Salmonella strains were isolated during this study. This accounted for 0. 2% of the overall CSF analyzed during the 5 years of study. Most of the patients (72.7%) were less than 2 years old. The average age of children was 2.63 years with an extreme of 1 month to 14 years and the sex ratio M/F was 0.83. The antimicrobial susceptibility was performed in vitro, to all the 11 salmonella isolated. The result revealed that 9/11(81.8%) strains were susceptible to ceftriaxone, Amikacin, and Cefoxitin. All the isolates (100%) were sensitive to Imipenem, Nalidixic acid, and Ciprofloxacin. Two strains of salmonella (18.2%) belonged to extended-spectrum beta lactamase (ESBL) producing group.The maximum resistance was observed against Ampicillin (100%), Amoxicillin/clavulanic acid (72.7%) and Gentamicin (27.3%).The Ampicillin MIC value showed 100% resistance to all the strains tested. This study confirmed that ceftriaxone may be used to treat Salmonella meningitis.The isolation of ESBL salmonella strain may be an alarm indicating the worldwide spray of multi-resistant bacterium. However, the limitation in the use of cephalosporin may prevent this increasing resistance.

VIEWS 12
Cover PDF

Ali A, Zanguina J. 2017.First report of Salmonella meningitis during 2011-2015 meningitis surveillance in Niger 5(6), pp.1-6.

Altun HU. 2014. Antimicrobial susceptibilities of clinical Acinetobacter baumannii isolates with different genotypes. Jundishapur Journal of Microbiology 7(12), pp. 2012-2015.

Anon. 2015. CLSI. Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard-Tenth Edition. CLSI document M2-A10. Wayne, PA: Clinical and Laboratory Standards Institute pp. 27-33.

Anon. 2015. Contribution de l’OMS à la gestion de l’épidemie de méningite au Niger.

Baud O, Aujard Y. 2013. Neonatal bacterial meningitis. Handbook of Clinical Neurology 112, pp.1109-1113.

Berk SL, McCabe WR. 1980. Meningitis Caused by Gram-Negative Bacilli. Ann Intern Med 93(2).

Christensen AC, Frederiksen W. 1988. Etiology of bacterial meningitis. Ugeskrift for laeger 150, pp.655-657.

Coldiron ME. 2017. Ciprofloxacin for contacts of cases of meningococcal meningitis as an epidemic response: study protocol for a cluster-randomized trial. Trials 18(1), p.294.

Doctor BA. 2001. Clinical outcomes of neonatal meningitis in very-low birth-weight infants. Clin Pediatr (Phila), 40(9), pp.473-480.

Fuller DG. 2003. Antibiotic treatment for bacterial meningitis in children in developing countries. Annals of tropical paediatrics 23(4), pp.233-53.

GEORGES AJ, 1AD. Aspects bactériologiques et cliniques des infections à Salmonella typhi en République Centrafricaine: bilan d’une étude de 3 années à Bangui (French). Bacteriological and clinical aspects of infections due to salmonella typhi in Central African Republic (English) 77(2), pp.164-174.

Kanchanapongkul J. 1995. Salmonella: a rare cause of meningitis in an adult. The Southeast Asian journal of tropical medicine and public health 26(1), pp.195-197.

Khemiri F, Boujaafar N, Aloui M. 1984. [Antibiotic resistance of Salmonella during 1982 and 1983]. Antibioresistance des Salmonella au cours des annees 1982 et 1983, 61, pp.107-121.

Kumar JD. 2014. A rare case of Salmonella typhi meningitis in a two-month-old infant: A case report. Pediatric Infectious Disease 6(3), pp.97-98.

LONGE AC. OMENE JA, OKOLO AA. 1984. Neonatal Meningitis in Nigerian Infants. Acta P?? diatrica 73(4), pp.477-481.

LOW LCK. 1984. Salmonella meningitis in infancy. Journal of Paediatrics and Child Health 20(3), pp.225-228.

Mahalakshmi R. 2013. Salmonella paratyphi B meningitis in an infant. Australasian Medical Journal, 2009 (181), pp.350-353.

Olivares Lopez F. 1981. [Meningitis caused by Salmonella]. Boletin Medico del Hospital Infantil de Mexico 38, pp.103-110.

Owusu-Ofori A, Scheld WM. 2003. Treatment of Salmonella meningitis: Two case reports and a review of the literature. International Journal of Infectious Diseases 7(1), pp.53-60.

Price EH,  Workman MR. 2000. Antibiotics for Salmonella meningitis in children. The Journal of antimicrobial chemotherapy 46(5), pp.653-5.

SL, GB. 1951. A case of salmonella (paratbyphoid B) meningitis in a premature inant with recovery. Harefuah 41(6), pp.96-98.

Thiombiano R. 2007. M éningites dues à Salmonella au CHU de Ouaga- dougou Burkina Faso (2000-2004) (1), pp.53-56.

Williamson M, Murti PK. 1990. A bacteriological study of purulent meningitis in children. Indian journal of pathology & microbiology 33(2), pp.157-160.

Workman MR, Price EH, Bullock P. 1999. Salmonella meningitis and multiple cerebral abscesses in an infant. International Journal of Antimicrobial Agents 13(2), pp.131-132.

Submit Manuscript