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Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh

A.K.M. Asaduzzaman, Imtiaj Hasan, M. Habibur Rahman, Abu Rayhan Mohammad Tareq

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Int. J. Biosci.16(3), 468-481, March 2020

DOI: http://dx.doi.org/10.12692/ijb/16.3.468-481


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In the present study, seaweed Sargassum binderi was extracted by the solvent ethanol and methanol. As phytoconstituents of both extracts were analyzed by gas chromatography-mass spectrometry (GC-MS), eighteen and nineteen compounds have been found from the ethanolic extract and methanolic extract, respectively. 1,2-Benzenedicarboxylic acid, diisooctyl esters was found in higher amounts and Pentadecanoic acid, 14-methyl-, methyl ester was the other major compounds present in both extracts. Total phenolic and flavonoid compounds were found to be as 11.890 mg gallic acid equivalent (GAE)/g and 269.542 mg catechin (CE)/g from ethanolic extract and 11.495 mg GAE/g and 266.936 mg CE/g from the methanolic extract. Good percentages of scavenging activity of DPPH, ABTS, total antioxidant and ferric reducing power have been observed in both extracts. 88.33% and 87.27% cell growth inhibition was observed in vitro at 176 µg/ml, respectively. Both S. binderi extracts showed mild toxicity against brine shrimp nauplii with LC50 values of 106.66 µg/ml and 125.82 µg/ml, respectively. Therefore we can say the ethanolic and methanolic extracts of S. binderi are a promising source of new molecules with possible applications as antioxidants and in cancer therapeutics.


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Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh

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