Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh

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Research Paper 01/03/2020
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Antioxidant and antiproliferative activity of phytoconstituents identified from Sargassum binderi seaweed extracts cultivated in Bangladesh

A.K.M. Asaduzzaman, Imtiaj Hasan, M. Habibur Rahman, Abu Rayhan Mohammad Tareq
Int. J. Biosci.16( 3), 468-481, March 2020.
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In the present study, seaweed Sargassum binderi was extracted by the solvent ethanol and methanol. As phytoconstituents of both extracts were analyzed by gas chromatography-mass spectrometry (GC-MS), eighteen and nineteen compounds have been found from the ethanolic extract and methanolic extract, respectively. 1,2-Benzenedicarboxylic acid, diisooctyl esters was found in higher amounts and Pentadecanoic acid, 14-methyl-, methyl ester was the other major compounds present in both extracts. Total phenolic and flavonoid compounds were found to be as 11.890 mg gallic acid equivalent (GAE)/g and 269.542 mg catechin (CE)/g from ethanolic extract and 11.495 mg GAE/g and 266.936 mg CE/g from the methanolic extract. Good percentages of scavenging activity of DPPH, ABTS, total antioxidant and ferric reducing power have been observed in both extracts. 88.33% and 87.27% cell growth inhibition was observed in vitro at 176 µg/ml, respectively. Both S. binderi extracts showed mild toxicity against brine shrimp nauplii with LC50 values of 106.66 µg/ml and 125.82 µg/ml, respectively. Therefore we can say the ethanolic and methanolic extracts of S. binderi are a promising source of new molecules with possible applications as antioxidants and in cancer therapeutics.


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