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Assessment toxicological of Opilia celtidifolia leaves used in Traditional Medicine in Benin (West Africa)

Téniola Isabelle Sacramento, Eric Agbodjento, Felix Guinnin, Jean-Marc Atègbo

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Int. J. Biosci.18( 6), 17-24, June 2021

DOI: http://dx.doi.org/10.12692/ijb/18.6.17-24


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Medicinal plants are continuously used as the first reflex of most populations in developing countries like Benin for primary health care. This unregulated or poorly rational use of these medicinal plants may present a potential toxicological risk. This study aimed to assess the toxicological characteristics of the ethanolic extract of the leaves of Opilia celtidifolia via the acute oral toxicity following the OECD 423 guideline of a single dose of 5000 mg/kg. Macroscopic observation of clinical signs of toxicity was recorded during the experimentation. Hematological and biochemical parameters of the liver and kidneys were evaluated with the histological study of these organs. As result, no mortality and no significant influence of the ethanolic extract of the leaves of Opilia celtidifolia on the biological parameters of the liver and the kidneys of the rats were not observed. These outputs reflect the safety of the leaves of Opilia celtidifolia and justify its use in traditional medicine in Benin (West Africa).


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Assessment toxicological of Opilia celtidifolia leaves used in Traditional Medicine in Benin (West Africa)

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