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Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats

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Research Paper 01/02/2014
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Biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats

Chinedu Imo, Friday O. Uhegbu, Ifeanacho Nkeiruka G., Egbeigwe Otito, Ezekwe A. S.
Int. J. Biomol. & Biomed.4( 2), 1-7, February 2014.
Certificate: IJBB 2014 [Generate Certificate]
Key: AcetaminophenBiochemicalGongronema latifoliumHistological changes

Abstract

This study examined the biochemical and histological changes associated with methanolic leaf extract of Gongronema latifolium in acetaminophen-induced hepatic toxicity in wistar albino rats. The serum liver enzymesALT, AST and ALP decreased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract. Protein concentration increased significantly (p<0.05) in the test animals treated with 600mg/kg of the leaf extract.The effect of the G. latifolium leaf extract seems to be dose dependent on the liver enzymes and protein concentration measured. The results showed that acetaminophen-induced hepatic toxicity in the wistar albino rats as observed in the negative control was reversed with the administration of the leaf extract of Gongronema latifolium (in groups 3, 4 and 5) in the test animals. The histological analysis of the liver showed that the extract had a normalising effect on the effected liver. These results indicate that the leaf extract of Gongronema latifolium exhibits biochemical and histological changes and can be used against some hepatic inflammations.

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