Comparative potential of Moringa oleifera and Bougainvillea spectabilis against pyrethrin (Deltamethrin) induced toxicity in albino rats
Paper Details
Comparative potential of Moringa oleifera and Bougainvillea spectabilis against pyrethrin (Deltamethrin) induced toxicity in albino rats
Abstract
Pesticidal induced toxicity proved to impose lethargic effects on mammalian hematological and serological parameters. Study was conducted to evaluate ameliorating potential of Bougainvillea spectabilis and Moringa oleifera against pyrethrin type-II induced toxicity in albino rats. Experiment carried out for 60 days by selecting 12 healthy male albino rats, in Animal House of Food Science and Technology department of Agriculture University Faisalabad, acclimatized for one week and kept under favorable condition at 23ºC ± 3ºC temperature. All of these rats divided into 4 groups. T0 taken as control group feed on simple diet and water receiving no chemicals and plant extract. T1 received daily dose of deltamethrin (1.55ml) bougainvillea spectabilis along with (150mg) per body weight orally, T2 received deltamethrin (1.56ml) along Moringa oleifera plant extract (150ml), T3 received deltamethrin only about 1.57ml. Each rat act as individual replica. Daily dosage of mixture was offered to all these groups. Autopsy of these rats done after considerable period to analyzed certain changes observed in weight, hematological parameters and serological parameters. RBC, MCV, WBC, HCT, HGB, MCH, MCHC, LYM, LYM% and serological parameters such as AST, ALT, ALP, TSP, urea and creatinine. Results were analyzed by using Anova and Tukey comparison test. Statistical analysis showed highly significant (P˂0.01) results of both anti-oxidant against pesticidal induced toxicity.
Abdel-Daim MA, Abuzead MMS, Halawa SM. 2013. Protective Role of against Acute Deltamethrin-Induced Toxicity in Rats. J. Vet. Med 8, 1-15.
Abdul HM, Salah M. 2003. Lycopene reduces deltamethrin effects induce thyroid toxicity and DNA damage in albino rats. J. Appl. Zool 66, 155-163.
Anwar F, Ashraf M, Bhanger MI. 2005. Inter-provenance variation in the composition of Moringa oleifera oilseeds from Pakistan. J. Chem. Soc 82, 45-51.
Ayaman M, Noha A, Saha B, Hassan A. 2018. The possible protective effect of Bougainvillea spectabilis leaves extract on estradiol valerate induced polycystic syndrome in rats. J. Environ. Res 22, 461-469.
Bjorling M, Anderson HR, Grandjean P. 2008. Potential development neurotoxicity of pesticides used in Europe. J. Environ. Health 7, 1-23.
Chauhan P, Mahajan S, Kulshrestha A, Shrivastava S, Sharma B. 2016. Bougainvillea spectabilis exhibits anti hyperglycemic and antioxidant activities in experimental diabetes. J. Evid. Integ. Med 21, 177-185.
Damalas CA, Eleftherohorinos IG. 2011. Pesticide exposure, safety issues and risk assessment indicator. J. Environ. Res 8, 1402-1419.
Do L, Aree T, Siripong P, Pham T, Nguyen P, Pyang S. 2016. Bougainvinones A-H, peltogynoids from the stem bark of purple Bougainvillea spectabilis and their cytotoxic activity. J. Nat. Prod 79, 939-945.
Gbaruko BC, Ogw EI, Igwe JC, Yu H. 2009. Organophosphate induced chronic neurotoxicity to health, environmental and risk exposure issues in developing nations of the world. J. Afr. Biotech 8, 5137-5141.
Issam C, Samer H, Zohra H, Monia Z. 2009. Toxic response to deltamethrin low doses on gonads, sex harmones and liipidperoxide in male rats following subcutaneous treatment. J. Toxicol. Sci 34, 663-670.
Kamath V, Joshi AK, Rajini PS. 2008. Dimethoate induced biochemical induced perturbations in rat’s pancreas and its attenuation by cashew nut skin extract. J. Biol. Sci 90, 58-65.
Laskowski DA. 2002. Physical and chemical properties of pyrethroids. J. Res. Environ 388, 15-21.
Leon LPS, Otero WMD, Gomez MD. 2015. Fever, Jaundice and Hepatitis: It is not always a Viral Infection. Rev. Col. Gastroenterol 30, 287-291.
Luty S, Latuszynska J, Tokarska M, Haratym A. 2000. Subacute toxicity of orally applied cypermethrin in swiss mice. J. Agric. Eniviron 7, 33-41.
Mani VM, Asha S, Sadiique AM. 2014. Pyrethroid Deltamethrin induced developmental neurodegenerative cerebral injury and ameliorating effect of dietary glycosidenaringin in male wistar rat. J. Neuro. Sci 4, 1-8.
Mie MS, Madiha W, Ali M, Gomma MS, Zeinab A. 2017. Study of chronic toxic effect of deltamethrin and dimethioate on brain of adult male albino rats. J. Medic. Toxicol 15, 29-32.
Naeem M, Ashraf A, Hafiz Safdar MZ, Khan MQ, Rehman SU, Iqbal R, Raza M, Ali J, Ahmad G. 2020. Biochemical Changes in Patients with Chronic kidney Failure In Relation to Complete Blood Count and Anemia. Int. J. Biosci 16(1), 267-271.
Rakam G, Sundararajan R. 2018. Cardioprotective and antioxidant effects of Bougainvillea glabra against isoproterenol induced myocardial necrosis in albino rats. J. Phyto. Med 10, 45-57.
Refaie AE, Mohafrash SM, Ibrahim AW, Mossa TH. 2017. Sub-acute 28-days oral toxicity, study of deltamethrin on female rats and the protective role of Moringa Tea. J. Sci. Res 12, 10-17.
Sameeh AM, Rehaam M, Amina RA, Abdel HR. 2018. The protective effect of moringa tea against cypermethrin induced hepatorenal dysfunction, oxidative stress and histopathological alternation in female rats. J. Clin. Res 11, 111-117.
Siddhuraju P, Becker K. 2003. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agro-climatic origins of drumstick tree (Moringa oleifera Lam.). J. Agric. Food. Chem 15, 2144-2155.
Spurlock F, Lee M. 2008. Qualitative Assessment of Impacts of Risk Management Strategies for Endosulfan on Multiple Crops. J. Environ. Prot 2, 3-10.
Yang C, Deng J. 2007. Intermediate syndrome following organophosphate insecticides poisoning. J. Chi. Med. Ass 70, 467-472.
Shahla Akash, Nazia Ehsan, Mehwish Malik, Noor Fatima, Muhammad Yaseen, Ayesha Saddique, Sadaf, Sadia Afsheen, Mahtab Ahmed (2020), Comparative potential of Moringa oleifera and Bougainvillea spectabilis against pyrethrin (Deltamethrin) induced toxicity in albino rats; IJB, V17, N3, September, P281-286
https://innspub.net/comparative-potential-of-moringa-oleifera-and-bougainvillea-spectabilis-against-pyrethrin-deltamethrin-induced-toxicity-in-albino-rats/
Copyright © 2020
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0