Welcome to International Network for Natural Sciences | INNSpub

Comparison of the effects of aqueous extracts of Persea americana Mill (Lauraceae) leaves, root and trunk bark on isolated wistar rats aorta and phytochemical screening

Research Paper | February 10, 2022

| Download 30

Hourfil-Gabin Ntougou Assoumou, Noreen Orianna Koumba Madingou, Idensi Bajin Ba Ndob, Rock Nze Ndong, Gontran Nsi Akoue, Henri-Paul Bourobou

Key Words:

Int. J. Biomol. & Biomed.14( 1), 1-8, February 2022


IJBB 2022 [Generate Certificate]


Hypertension or elevated blood pressure is a serious medical condition that significantly increases the risks of heart, brain, kidney and other diseases. The aim of this study was to determine and compare the activities of avocado (Persea americana; family Lauraceae) leaves, root and trunk bark extracts on isolated aorta of wistar rats and perform phytochemical screening. The effects of the aqueous extracts of theselected plant materials were studied on the vasomotor activity of isolated rat aorta. Lastly, the vasodilatory effect of the extracts under study were reproduced in the laboratory using the adrenaline and potassium chloride solutions that are both well-known for their vasoconstrictor effect on smooth muscle cells  constituting the aorta. The amplitudes of the responses varied depending on the type of extracts. Our results revealed that the leaf extracts was the part of the plant that had the highest effect on the isolated aorta. These extracts produced a continuous vasorelaxation effect in 22.22% of the cases studied against a transient vasorelaxation effect in 77.78% of all cases. The vasodilation observed in our study could be attributed to the presence of antihypertensive chemical compounds. However, the cause of the transient vasorelaxation effects remains to be determined.


Copyright © 2022
By Authors and International Network for
Natural Sciences (INNSPUB)
This article is published under the terms of the Creative
Commons Attribution Liscense 4.0

Comparison of the effects of aqueous extracts of Persea americana Mill (Lauraceae) leaves, root and trunk bark on isolated wistar rats aorta and phytochemical screening

Andre Raponda-Walker A, Sillans R. 2003. Les plantes utiles du Gabon (French) Broché – 17 décembre, page 214.

Brewster LM, van Montfrans GA, Kleijnen J. 2004. Systematic review: antihypertensive drug therapy in black patients. Ann Intern Med 141(8), 614-27. DOI: 10.7326/0003-4819-141-8-200410190.

Danielle I Lee. 2017. Crystal Acosta, Christopher M. Anderson, Hope D. Anderson. Peripheral and Cerebral Resistance Arteries in the Spontaneously Hypertensive Heart Failure Rat: Effects of Stilbenoid Polyphenols. Molecules 22(3), 380. Published online 2017 Feb 28. DOI: 10.3390/molecules22030380.

Deb L, Laishram S, Khumukcham N, Ningthoukhongjam D, Nameirakpam SS, Dey A, Moirangthem DS, Talukdar NC, Ningthoukhongjam TR. 2015. Past, present and perspectives of Manipur traditional medicine: A major health care system available for rural population in the North-East India. J Ethnopharmacol 169, 387-400. DOI: 10.1016/ j.jep.2014.12.074. Epub 2015 Apr 18.

Kanjanahattakij N, Kwankhao P, Vathesatogkit P, Thongmung N, Gleebbua Y, Sritara P, Kitiyakara C. 2019. Herbal or traditional medicine consumption in a Thai worker population: pattern of use and therapeutic control in chronic diseases. BMC Complement Altern Med 19(1), 258. DOI: 10.1186/s12906-019-2652-z.

Lamblin N, Susen S, Dagorn J, Mouquet F, Jude B, Van Belle E, Bauters C, de Groote P. 2005. Prognostic significance of circulating levels of angiogenic cytokines in patients with congestive heart failure. Am Heart J 150(1), 137-43. DOI: 10.1016 /j.ahj.2005.03.047.

Lurbe I Ferrer E. 2018. [Examining hypertension in children and adolescents: Clinical implications of the differences between the European and American Guidelines]. An Pediatr (Barc) 89(4), 255.e1-255.e5. DOI: 10.1016/j.anpedi.2018.08.004. Epub 2018 Sep 13.

Mbang A, Ozolabi SI, Coker HAB. 2005. Vasorelaxant action of aqueous extract of the leaves of Persea americana on isolated thoracic rat aorta, Fitoterapia 76(6), 567-73

Monika Szulińska, Marta Stępień, Matylda Kręgielska-Narożna, Joanna Suliburska, Damian Skrypnik, Monika Bąk-Sosnowska, Magdalena Kujawska-Łuczak, Małgorzata Grzymisławska, Paweł Bogdański. 2017. Effects of green tea supplementation on inflammation markers, antioxidant status and blood pressure in NaCl-induced hypertensive rat model. Food Nutr Res. 61(1), 1295525. Published online 2017 Mar 3. DOI: 10.1080/16546628.2017.1295525.

Negishi J, Kawanami M, Terada Y, Matsuhashi C, Ogami E, Iwasaka K, Hongo T. 2004. Effect of lifestyle on periodontal disease status in diabetic patients. J Int Acad Periodontol 6(4), 120-4.

Ojewole JA, Amabeoku GJ. 2006. Anticonvulsant effect of Persea americana leaf aqueous extract in mice, Phytotherapy resaerchy 20(8), 696-700.

Paulin Nyadjeu, Elvine Pami Nguelefack-Mbuyo, Albert Donatien Atsamo, Telesphore Benoît Nguelefack, Alain Bertrand Dongmo, Albert Kamanyi. 2013. Acute and chronic antihypertensive effects of Cinnamomum zeylanicum stem bark methanol extract in L-NAME-induced hypertensive rats. BMC Complement Altern Med 13, 27. Published online 2013 Jan 31. DOI: 10.1186/1472

Tabeshpour J, Razavi BM, Hosseinzadeh H. 2017. Effects of Avocado (Persea americana) on Metabolic Syndrome: A Comprehensive Systematic Review.Phytother Res. 31(6), 819-837. DOI: 10.1002/ptr.5805. Epub Apr 10.

Tona, Kambu, Cimanga, Apers, DeBruyne, Piertes, Totte, Vlietinck. 1999. Biological screening of traditional preparation from some medicinal plants used an antidarrhea in Kinshasa, Congo, Phymedecine 6, 59-66.

WHO. 2019 : https://www.who.int/news-room/fact-sheets/detail/hypertension.

Yasir M, Das S, Kharya MD. 2010. The phytochemical and pharmacological profile of Persea americana Mill. Pharmacogn Rev. 4(7), 77-84. DOI: 10.4103/0973-7847.65332.

Zague Hermann Win-wa. 2009. Thèse présentée et soutenue publiquement le 14 décembre. Étude des plantes a activité antihypertensive de la pharmacopée du Burkina Faso: évaluation in vitro de l’effet vasodilatateur de l’extrait aqueux des écorces de tronc de Lannea microcarpa ENGL et KRAUSSE (anacardiaceae). https://www.doc-developpement-durable.org

Zohreh Sattar, Mehrdad Iranshahi. 2017. Phytochemistry and pharmacology of Ferula persica Boiss: A review. Iran J Basic Med Sci 20(1), 1-8. DOI: 10.22038/ijbms.2017.8085.