home icon user icon
Welcome to International Network for Natural Sciences | INNS Pub.
Home My Account
Submit Manuscript
double_slash
breadcumb_bg

Effect of extensive consumption of black pepper on intestinal glands of male rats

Paper Details

Research Paper 01/11/2015
Views (202) Download (2)
current_issue_feature_image
publication_file

Effect of extensive consumption of black pepper on intestinal glands of male rats

Fatma A. Al-Nefeiy
Int. J. Biosci.7( 5), 100-106, November 2015.
Certificate: IJB 2015 [Generate Certificate]
Key: Black PepperHistologyIntestinal glandsRatsTransmission electron microscopy

Abstract

The objectives of the present work was conducted to investigate the effect of oral administration of water extract of black pepper (Piper nigrum) on intestinal glands of male rats. Rats were divided randomly into two groups, Group I: control group, Group II: black pepper group , treated with 500 mg / kg black pepper for 12 weeks. The microscopic examination of the black pepper treated animals revealed damage and irregular arrangement of duodenal glands, decomposition of duodenal glands inflammatory cells infiltrated, vacuolations with necrotic nuclei. Transmission electron photographs of the duodenal glands showing deformed nuclei and dilated of intercellular spaces, necrotic glandular cells with deformed shape nuclei. Lysis of cell organelles with karyorrhexis nuclei, fragmented with dilatation parts of rough endoplasmic reticulum and mitochondrial destructed also were seen.

VIEWS 2
Cover PDF

Khajuria1 A, Thusu N, Zutshi U. 2002. Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: Influence on brush border membrane fluidity, ultrastructure and enzyme kinetics. Phytomedicine 9, 224–231.

Chaiyasit K, Khovidhunkit W, Wittayalertpanya S. 2009.Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J. Medical. Association. Thailand 92, 108-113.

Chukwu LO, 2006. Histophysiological and basal metabolic responses of albino rat, Rattusnorvegicus (L) exposed to aqueous pepper extracts. African Journal of Biotechnolgy 5, 1279-1283.

Durham SK, Brouwer A, Barelds RJ. 1990. Comparative endotoxininducedhepatic injury in young and aged rats. Journal of Pathology 162, 341-349.

Galib AM, AL-Kassie, Akhil M, Mohseen Raghad A, Abd-AL-Jaleel. 2011.Odification of productive performance and physiological aspects of broilers on the addition of a mixture of cumin and turmeric to the diet. Research opinion in Animal and veterinary Sciences 1(3), 169-173.

Govindarajan VS, Sathyanarayana MN. 1991. Capsicum production, technology, Chemistry and quality. Part V. Impact on physiology, pharmacology, nutrition and metabolism: structure, pungency, painand desensitization sequences. Crit. Rev. Food Science. Nutrition 29, 435–474.

Kaleem M, Sheema Sarmad H, Bano B. 2005. Protective effects of Piper nigrumand Vincaroseain alloxan induced diabetic rats. Indian Journal ofPhysioogy and Pharmacology 49(1), 65-71.

Mittal R, Gupta RL. 2000. In vitro antioxidant activity of piperine. Methods and Findings in Experimental and Clinical Pharmacology 22, 271-274.

Nopaintaya W, Nye SW. 1974. Duodenal mucosal response to thepungent principle of Hot pepper (capsaicin) in rat: light and Electron microscopic study. Toxicology and applied pharmacology 30, 149-161.

Nwaopara AO, Anyanwu LC, Oyinbo CA, Anaikot IC. 2004. Thehistological changes In pancreas of Wister rats fed with dietscontaining Yaji (Local meat sauce). Journal Experimental Clinical. Anatomy 3, 44-47.

Nwaopara AO, Odike MAC, Inegbenebor U, Adoye MI. 2007. The combined effects of excessive consumption of ginger, clove, red pepper and black pepper on the histology of the liver. Pakistan. Journal of Nutrition 6, 524-527.

Rauscher FM, Sanders RA, Watkins JB 3rd. 2000. Effects of piperine on antioxidantpathways in tissues from normal and streptozotocin-induceddiabetic rats. Journal of Biochemistry and Molecular Toxicology 14, 329-34.

Samaranayake MD, Wickramasinghe SM, Angunawela P, Jayasekera S, Iwai S, Fukushima S. 2000. Inhibition of chemically induced livercarcinogenesis in Wistar rats by garlic (Allium sativum). Phytother Research 14, 564-567.

Selvendiran K, Mumtaz Banu S, Sakthisekaran D. 2005. Oral supplementation of piperine altered phase II enzymes and reduced DNA damage and DNA-protein cross links in B(a)p induced experimental lung carcinogenesis. Mol. Cell Biochemistry 268, 141-147.

Shahverdi A, Kheiri F, Faghani M, Rahimian Y, RafieeA. 2013. The effect of use red pepper (Capsicum annum L) and black pepper (Piper nigrum L) on performance and hematological parameters of broiler chicks. European Journal of Zoological Research, 2(6), 44-48.

Srinivasan K. 2005. Role of spices beyond food flavouring:Nutraceuticals with multiple health effects. Food Reviews International 21, 167–188.

Vijayakumar RS, Surya D, Nalini N. 2004. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress. Redox Reproduction 9, 105-10.

Submit Manuscript