Effect of extensive consumption of black pepper on intestinal glands of male rats

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Research Paper 01/11/2015
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Effect of extensive consumption of black pepper on intestinal glands of male rats

Fatma A. Al-Nefeiy
Int. J. Biosci.7( 5), 100-106, November 2015.
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The objectives of the present work was conducted to investigate the effect of oral administration of water extract of black pepper (Piper nigrum) on intestinal glands of male rats. Rats were divided randomly into two groups, Group I: control group, Group II: black pepper group , treated with 500 mg / kg black pepper for 12 weeks. The microscopic examination of the black pepper treated animals revealed damage and irregular arrangement of duodenal glands, decomposition of duodenal glands inflammatory cells infiltrated, vacuolations with necrotic nuclei. Transmission electron photographs of the duodenal glands showing deformed nuclei and dilated of intercellular spaces, necrotic glandular cells with deformed shape nuclei. Lysis of cell organelles with karyorrhexis nuclei, fragmented with dilatation parts of rough endoplasmic reticulum and mitochondrial destructed also were seen.


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