Effect of individualized weight loss program on fasting Interleukin 6 levels in obese adult subjects
Paper Details
Effect of individualized weight loss program on fasting Interleukin 6 levels in obese adult subjects
Abstract
Inflammation is hypothesized to play a central role in obesity and its related diseases; although the molecular mechanisms for this are less understood. Twenty-four healthy adult obese men were enrolled for this study through local advertising. The objective of study was to investigation of serum interleukin-6 response to long term exercise training in mentioned subjects that divided to exercise or control group. Subjects in exercise group were completed three months aerobic training and control subject did not participate in exercise program. Pre and post training of anthropometrical markers and fasting serum IL-6 were measured in two groups. Paired samples T test was used to determine significant difference between per and post values. Serum IL-6 levels were significantly increased in exercise group (from 2.77±0.24 to 3.36±0.41 pg/ml p<0.0001) and did not change in control group. All anthropometrical markers decreased after exercise program in exercise group (p ≤ 0.05). In conclusion, serum IL-6 response to exercise training is appears to be independent of weight status.
Bonyadi M, Badalzadeh R, Mohammadi M, Poozesh S, Salehi I. 2009. The effect of regular training on plasma cytokines response in healthy and diabetic rats. Saudi Medical Journal 30(11), 1390-4.
Brown M, Sinacore DR, Binder EF, Kohrt WM. 2000. Physical and performance measures for the identification of mild to moderate frailty. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 55, 350–355.
Charles P, Lambert, Nicole R, Wright, Brian N, Finck, Dennis T, Villareal. 2008. Exercise but not diet-induced weight loss decreases skeletal muscle inflammatory gene expression in frail obese elderly persons. Journal of Applied Physiology 105, 473–478.
De Luis DA, Aller R, Izaola O, Gonzalez Sagrado M, Bellioo D, Conde R. 2007. Effects of a low-fat versus a low-carbohydrate diet on adipocytokines in obese adults. Hormone Research 67(6), 296-300.
Febbraio MA, Pedersen BK. 2002. Muscle-derived interleukin-6: mechanisms for activation and possible biological roles. Federation of American Societies for Experimental Biology 16, 1335-1347.
Ferrucci L, Harris TB, Guralnik JM, Tracy RP, CortiMC, Cohen HJ. 1999. Serum IL-6 level and the development of disability in older persons (see comments). Journal of the American Geriatrics Society 47, 639–646
Ferrucci L, Penninx BW, Volpato S, Harris TB, Bandeen-Roche K, Balfour J. 2002. Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels. Journal of the American Geriatrics Society 50, 1947–1954.
Fischer CP, Hiscock N, Basu S. 2004. Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. Journal of Physiology 558, 633-645.
Gielen S, Adams V, Mobius-Winkler S, Linke A, Erbs S, Yu J, Kempf W. 2003. Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure. Journal of the American College of Cardiology 42, 861–868.
Grau AJ, Buggle F, Becher H, Werle E, HackeW. 1996. The association of leukocyte count, fibrinogen and C- reactive protein with vascular risk factors and ischemic vascular diseases. Thrombosis Research 82, 245-55.
Kern PA, Saghizadeh M, Ong JM. 1995. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. Journal of Clinical Investigation 95, 2111-19.
Larsen AI, Lindal S, Aukrust P, Toft I, Aarsland T, Dickstein K. 2002. Effect of exercise training on skeletal muscle fibre characteristics in men with chronic heart failure. Correlation between skeletal muscle alterations, cytokines and exercise capacity, International Journal of Cardiology 83(1), 25-32.
Luheshi GN, Gardner JD, Rushforth DA, Loudon AS, Rothwell NJ. 1999. Leptin actions on food intake and body temperature are mediated by IL-1. Proceedings of the National Academy of Sciences of the United States 96, 7047-7052.
Moldoveanu AI, Shephard RJ, Shek PN. 2000. Exercise elevates plasma levels but not gene expression of IL-1beta, IL-6, and TNF-alpha in blood mononuclear cells. Journal of Physiology 89, 1499-1504.
Monzillo LU, Hamdy O, Horton ES, Ledbury S, Mullooly C. 2003. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity Research 11(9), 1048-54.
Pasare C. and Medzhitov R. 2003. Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 299, 1033-1036.
Pedersen BK, Hoffman-Goetz L. 2000. Exercise and the immune system: regulation, integration and adaption. Physiological Reviews 80, 1055-1081.
Pedersen BK, Steensberg A, Fischer C. 2003. Searching for the exercise factor – is IL-6 a candidate. Journal of Muscle Research and Cell Motility 24, 113-119.
Pedersen BK, Steensberg A, Schjerling P. 2001. Muscle- derived interleukin-6: possible biological effects. Journal of Physiology 536, 329-337.
Pedersen BK. 2006. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays in Biochemistry 42, 105–117.
Pedersen M, Steensberg A, Keller C. 2004. Does the aging skeletal muscle maintain its endocrine function? Exercise Immunology Review 10, 42-55.
Pickup JC, Mattock MB, Chusney GD, Burt D. 1997. NIDDMas a disease of the innate immune system: association of acute-phase reactants and interleukin-6 with metabolic syndrome X. Diabetologia 40, 1286-92.
Rauchhaus M, Doehner W, Francis DP. 2000. Plasma cytokine parameters and mortality in patients with chronic heart failure, Circulation 102(25), 3060–67.
Reuben DB, Cheh AI, Harris TB, Ferrucci L, Rowe JW, Tracy RP, Seeman TE. 2002. Peripheral blood markers of inflammation predict mortality and functional decline in high-functioning community-dwelling older persons. Journal of the American Geriatrics Society 50, 638–644.
Stith R. 1994. Endocrine and carbohydrate responses to interleukin-6 in vivo. Circulatory Shock 44, 210-15.
Tsigos C, Papanicolaou DA, Kyrou I, Defensor R, Mitsiadis CS, Chrousos GP. 1997. Dose-dependent effects of recombinant human interleukin-6 on glucose regulation. Journal of Clinical Endocrinology & Metabolism 82, 4167- 70.
Visser M, Pahor M, Taaffe DR, Goodpaster BH, Simonsick EM, Newman AB. 2002. Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study. Journals of Gerontology Series A: Biological Sciences and Medical Sciences 57, 326–332.
Ying BW, Song XB, Fan H, Wang LL, Li YS, Cheng Z. 2008. Plasma ghrelin levels and weight loss in Chinese Uygur patients with chronic obstructive pulmonary disease. Journal of International Medical Research 36(6), 1371-7.
Eizadi Mojtaba, Samarikhalaj Hamidreza, Kiani Fatemeh, Dooaly Hossein, 2014. Effect of individualized weight loss program on fasting Interleukin 6 levels in obese adult subjects. J. Biodiv. Environ. Sci., 4(2), 165-170.
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