Effect of Mentha piperita L. fatty oil on full thickness excised wound healing in rabbits
Paper Details
Effect of Mentha piperita L. fatty oil on full thickness excised wound healing in rabbits
Abstract
The present work aimed to determine the chemical characterization of the aerial partand to assess full thickness excised wound healing activity of the fatty oil of Mentha piperita L. (MPFO) grown in Algerian eastern part. The fatty acid composition of M. piperita L. leaves hexane extract was analysed by GC-MS. Total thickness excised wound healing activity of hexane extract was carried out on the back of nine adult male New Zealand rabbits; comparing to a reference drug effects (Madecassol®).The treatments were repeated once daily until complete healing. For each four days of post-excision, the percentage of wound contraction was evaluated, and the different healing times were noted. The results showed that M. piperita L. leaves contain low levels of oil (1.79%), and GC/MS results of its oil have revealed the presence of different fatty acids among which the main constituents were oleic (43.16 ± 1.01%), palmitic (37.70 ± 0.94%) and linoleic (11.13± 0.45%) acids. The wound healing activity and the level of wound contraction were significantly higher in M. piperita L. fatty oil (MPFO) compared to untreated wounds. In addition, both of MPFO and Madecassol® accelerated significantly wound healing activity and their healing times were faster than CONT group. We conclude that M. piperita L. fatty oil promotes significantly (p< 0.05) wound contraction and reduces epithelization period in rabbit model.
Adlouni A. 2010. L’huiled’argan, de la nutrition à la santé. Phytothérapie 8(2), 89-97. http://dx.doi.org/10.1007/s10298-010-0538-9.
Alizadeh AM, Ahmadi A, Mohammadzadeh A, Paknejad M, Mohagheghi M. 2009. The effect of HESA-A, an herbal-marine compound, on wound healing process: An experimental study. Research Journal of Biology. Science 4(3), 298-302.
Benhammou N, Atik Bekkara F, Panovska TK. 2008. Antioxidant and antimicrobial activities of the Pistacia lentiscus and Pistacia atlantica extracts. African Journal of Pharmacy and Pharmacology 2(2), 22-28. www.academicjournals.org/ajpp
Boulebda N, Belkhiri A, Belfadel F, Bensegueni A, Bahri L. 2009. Dermal Wound Healing Effect of Pistacia lentiscus Fruit’s Fatty Oil. Pharmacognosy Research 1(2), 66-71. www.phcogres.com/text.asp?2009/1/2/66/58134.
Djerrou Z. 2014. Anti-hypercholesterolemic effect of Pistacia lentiscus fatty oil in egg yolk-fed rabbits: a comparative study with simvastatin. Elsevier, Chinese Journal of Natural Medicines 12(8), 0561-0566. http://dx.doi.org/10.1016/S1875-5364(14)60086-8
Enoch S, Leaper DJ. 2005. Basic science of wound healing. Surgery 23(2),37-42. http://dx.doi.org/10.1016/j.mpsur.2007.11.005.
Ertas A, Boğa M, Yılmaz MA, Yesil Y, Hasimi N, Kaya MS, Temel H, Kolak U. 2014. Chemical compositions by using LC-MS/MS and GC-MS and biological activities of Sedum sediforme (Jacq.). Journal of Agriculture. Food Chemistry 62, 4601-4609. http://dx.doi.org/10.1021/jf500067q.
Habbu PV, Joshi H, Patil BS. 2007. Potential wound healing healers from plant origin. Pharmacognosy Reviews 1(2), 271-282.
Iserin P. 2001. Encyclopédie des Plantes Médicinales, Identification, Preparation, Soin. 2ieme edition, Larousse /VUEF, 13-16 P.
Khallouki F, Haubner R, Ricarte I, Erben G, Klika K, Ulrich CM, Owen RW. 2015. Identification of polyphenolic compounds in the flesh of Argan (Morocco) fruits. Food Chemistry 179(15), 191-198. https://doi.org/10.1016/j.foodchem.2015.01.103.
Kris-Etherton PM. 1999. Mono-unsaturated fatty acids and risk of cardiovascular disease. Journal Circulation 100(11), 1253-1258. http://dx.doi.org/10.1161/01.CIR.100.11.1253.
Lazarus GS, Cooper DM, Knighton DR, Margolis DJ, Pecoraro RE, Rodeheaver G, Robson MC. 1994.Definitions and guidelines for assessment of wounds and evaluation of healing. Dermatology130(4), 489-93. http://dx.doi.org/10.1001/archderm.1994.01690040093015.
Mc KAY DL, BLUMBERG JB. 2006. A review of the bioactivity and potential health benefts of peppermint tea (Mentha piperita L.). Phytotherapy Research 20(8), 619-33. http://dx.doi.org/10.1002/ptr.1936.
Menvielle-Bourg FJ. 2008. L’extrait huileux au CO2 supercritique de baies et de graines d’argousier (Hippophae rhamnoides L.) et ses effets sur la peau et les muqueuses. Phytothérapie. Pharmacognosie 6, 3-7. http://dx.doi.org/10.1007/s10298-008-0358-3.
Nguyen DT, Orgill DP, Murph GF. 2009. The Pathophysiologic Basis for Wound Healing and Cutaneous Regeneration. Biomaterials for Treating Skin Loss. Chapter 4.Woodhead Publishing (UK/Europe) & CRC Press (US), Cambridge/Boca Ratonpp 25-57.
Priya KS, Gnanamani A, Radhakrishnan N0, Babu M. 2002. Healing potential of Daturaalba on burn wound in albino rats. Journal of Ethnopharmacology 83(3), 193-199. https://doi.org/10.1016/S0378-8741(02)00195-2.
Rieger S, Zhao H, Martin P, Abe K, Lisse TS. 2014. The role of nuclear hormone receptors in cutaneous wound repair. Cell biochemistry and function 33(1), 1–13. http://dx.doi.org/10.1002/cbf.3086.
Sousa CMM, Silva HR, Vieira-Jr GM, Ayres MCC, Costa CLS, Araújo DS, Cavalcante LCD, Barros EDS, Araújo PBM, Chaves MSBMH. 2007. Fenóistotais e atividadeantioxidante de cinco plantas medicinais. Química Nova 30(2), 351-355, www.dx.doi.org/10.1590/S010040422007000200021.
Srivasta P, Durgaprasad S. 2008. Burn wound healing property of Cocos nucifera: an Appraisal. Indian Journal of Pharmacology 40(4), 144-146. http://dx.doi.org/10.4103/0253-7613.43159.
Stadelmann WK, Digenis AG, Tobin GR. 1998.Physiology and healing dynamics of chronic cutaneous wounds. The American journal of surgery 176(2A),26–38. http://dx.doi.org/10.1016/S0002-9610(98)00183-4.
Toporcer T, Grendel T, Vidinsky B, Gal, P, Sabo J, Hudak R. 2006. Mechanical properties of skin wounds after Atropa bellâdonna application in rats. Journal of Metals, Materials, and Minerals 16(1), 25-29.
Wang R, Lechtenberg M, Sendker J, Petereit F, Deters A, Hensel A. 2013. Wound-healing plants from TCM: In vitro investigations on selected TCM plants and their influence on human dermal fibroblasts and keratinocytes. Fitoterapia 84, 308-317. https://doi.org/10.1016/j.fitote.2012.12.020.
WHO, World Health Organization. 2002. WHO traditional medicine strategy 2002-2005. Geneva.
Ahmed Boukeloua, Mustafa Abdullah Yilmaz, Hamdi Temel, 2017. Effect of Mentha piperita L. fatty oil on full thickness excised wound healing in rabbits. Int. J. Biosci., 11(6), 68-74.
Copyright © 2017 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.