Effects of the aqueous extract of Persea americana Mill (Lauraceae) leaves on the rat isolated aorta: evaluation of vasomotility and acute toxicity
Paper Details
Effects of the aqueous extract of Persea americana Mill (Lauraceae) leaves on the rat isolated aorta: evaluation of vasomotility and acute toxicity
Abstract
Nowadays, hypertension is a real scourge for public health. Objectives: The study consisted in evaluating the effects of aqueous extracts of Persea americana Mill leaves (Leucaceae) on both the vasomotility and the acute toxicity of the isolated rat aorta. Study of the effects of the aqueous extract of Persea americana leaves on isolated rat aorta: qualitative approaches to vasomotility and acute toxicity. The animals used in this study were adult albino rats of the Wistar type (Rattus Norvengicu, 150-250mg). The chemical composition of the extract was considered by phytochemical screening. The effect of the extract of the traditional healer pre-contracted with Potassium Chloride produces a slight temporary relaxation with each dose before contracting again and waiting for a value greater than the previous value. It is the same for this same extract of the traditional practitioner pre-contracted with Adrenaline, the organ relaxes then recontracts, and this with each dose of the extract administered. The DL50 showed that no signs of intoxication were observed in the treated animals. None mortality or oral toxicity was recorded in animals. Aqueous extracts prepared in the laboratory compared to traditional healer decoction cause relaxation of the aorta. Furthermore, the phytochemical screening revealed the presence of many antihypertensive components in the aqueous extract. Our study on the isolated rat aorta allowed us to observe a relatively more or less mild relative vasorelaxation. Others studies would be required for the plant to be designated for the development of an improved traditional medicine.
Bey-Marrié S, Solange D, Ingrid T, Charlotte MB, Joerg JM, Tamara K. 2019. Screening strategies for hypertension: a systematic review protocol. BMJ Open 9(1), e025043. Published online 2019 Jan 15. DOI: 10.1136/bmjopen-2018-025043.
Feuya Tchouya GR, Foundikou H , Lebibi J, Choudhary MI , Menkem EZ , Nantia EA, et al. 2015. Phytochemical Analysis, Antioxidant and Antimicrobial Properties of the Leaves and Stem Bark of Scyphocephalium ochocoa Warb (Myristicaceae). J Pharmacogn Nat Prod 1, 1 DOI: 10.4172/2472-0992.1000111.
Germosén-Robineau L. 2007. Pharmacopée caribéenne. TRAMIL / IRD. Date parution. Janvier, pages 332-33.
Harborne AJ, Shute JK, Smith ME. 1984. Release of hydrolases and acetylcholine sensitivity in rat skeletal muscle. J Physiol 352. 385-393. DOI: 10.1113/jphysiol.1984.sp015298.
Hodge JH, Sterner. 1943. The Skin Absorption of Triorthoeresyl Phosphate as shown by Radioactive Phosphorus. Journal of Pharmacology and Experimental 79 No.3 pp.225-34 ref.10.
Jeon BH, Kim CS, Kim HS, Park JB, Nam KY, Chang SJ. 2000. Effect of Korean red ginseng on blood pressure and nitric oxide production. Acta Pharmacol Sin 21(12), 1095-100.
John P, Bolton MA, MSc, MB, FRCS, Douglas PMSc, et al. 1978. Stimulation of mucus and nonparietal cell secretion by the E2 prostaglandins. The American Journal of Digestive Diseases 23, pages 359-364.
Kearney PM, Whelton M, Reynolds K, Whelton PK, He J. 2004. Worldwide prevalence of hypertension: a systematic review. J Hypertens 22 (1), 11-9.
Konan NA, Bacchi EM, Lincopan N, Varela SD, Varanda EA. 2007. Acute, subacute toxicity and genotoxic effect of a hydroethanolic extract of the cashew (Anacardium occidentale L.). J Ethnopharmacol. Mar 1; 110(1), 30-8. Epub 2006 Sep 15.
Lamblin N, Cuilleret FJ, Helbecque N, Dallongeville J, Lablanche JM, Amouyel P, et al. 2005. A common variant of endothelial nitric oxide synthase (Glu298Asp) is associated with collateral development in patients with chronic coronary occlusions. BMC Cardiovasc Disord 15, 5:27.
Liu JC, Hsu FL, Tsai JC, Chan P, Liu JY, Thomas GN. 2003. Antihypertensive effects of tannins isolated from traditional Chinese herbs as non-specific inhibitors of angiontensin converting enzyme. Life Sci 8, 73(12), 1543-55.
Lown JW. 1983. The mechanism of action of quinone antibiotics. Mol Cell Biochem 55(1), 17-40.
Mbang T, Thévenon MF, Gérard J, Thibaut A, Thibaut B. 2005. Importance of the wood secondary metabolites on the physical properties and the durability of four tropical wood species from Cameroon. International Forestry Review 7(5), Résumé : 177-178. IUFRO World Congress. 22, Brisbane, Australie, 8 Août 2005/13.
N’do JY, Hilou A, Ouedraogo N, Sombie EN, Traore TK. 2018. Phytochemistry, Antioxidant, and Hepatoprotective Potential of Acanthospermum hispidum DC Extracts against Diethylnitrosamine-Induced Hepatotoxicity in Rats. Medicines (Basel) 7, 5(2). pii: E42.
Nsi AG, Alain S, Richard O, Ibrahim, Bertrand M. 2019a. Study of the Mandrillus sphinx (Cercopithecoidea) diet behaviour from the Lekedi Park (South-East, Gabon) as a valuable approach for drugs discovery. International Journal of Advances in Scientific Research and Engineering 5(5), 68-105. DOI: 10.31695/IJASRE.2019.33040.
Nsi AG, Obame LC, Ondo JP, Ibrahim B, Otogo NES, Tapoyo SY et al. 2013. Phytochemical composition and antiradical activity of Sakersia africana Hook. f. medicinal plant from Gabon. Int. J. Biomol. Biomed 3, 1-8.
Nsi AG, Pierre Philippe MN, Richard O, Arsenemm, Ibrahim B. 2019. Nutritional Porospects, Antioxydant and antibacterial activities of some Food Plant Consumed by Wild Mandrill (Mandrillus sphinx) Population From Lekedi Park (Bakoumba, Gabon). Int. J. Adv. Res 7(2), 116-136.
Ojewole JA, Kamadyaapa DR, Gondwemm, Moodley K, Musabayane CT. 2007 Cardiovascular effects of Persea americana Mill (Lauraceae) (avocado) aqueous leaf extract in experimental animals. Cardiovasc J Afr 18(2), 69-76.
Orji EO, Fasubaa OB, Adeyemi B, Dare FO, Onwudiegwu U, Ogunniyi SO. 2002. Mortality and morbidity associated with misdiagnosis of ectopic pregnancy in a defined Nigerian population. J Obstet Gynaecol. Sep 22(5), 548-50.
Paredes MD, Romecín P, Atucha NM, O’Valle F, Castillo J, Ortiz MC, et al. 2018. Moderate Effect of Flavonoids on Vascular and Renal Function in Spontaneously Hypertensive Rats. Nutrients 10(8). pii: E1107.
Peng WD. 1999. Hypotensive effect of tenuifolic saponin and its mechanism. Zhongguo Yao Li Xue Bao 20(7), 639-42.
Perez-Vizcaino F, Duarte J, Jimenez R, Santos-Buelga C, Osuna A. 2009. Antihypertensive effects of the flavonoid quercetin. Pharmacol Rep 61(1), 67-75.
Raponda-Walker A, Sillans R. 2003. Les plantes utiles du Gabon (Français) Broché, page 214.
Razavi BM, Arasteh E, Imenshahidi M, Iranshahi M. 2015. Antihypertensive effect of auraptene, a monoterpene coumarin from the genus Citrus, upon chronic administration. Iran J Basic Med Sci 18(2), 153-8.
Ryan JJ, Hanes DA, Corroon J, Taylor J, Bradley R. 2019. Prospective Safety Evaluation of a Cardiovascular Health Dietary Supplement in Adults with Prehypertension and Stage I Hypertension. J Altern Complement Med 25(2), 249-256.
Sarr M, Ngom S, Kane MO, Wele A, Diop D, Sarr B, et al. 2009. In vitro vasorelaxation mechanisms of bioactive compounds extracted from Hibiscus sabdariffa on rat thoracic aorta. Nutr Metab (Lond). Nov 2, 6, 45.
Tjeck OP, Souza A, Mickala P, Lepengue AN, M’Batchi B. 2017. Bio-efficacy of medicinal plants used for the management of diabetes mellitus in Gabon: An ethnopharmacological approach. J Intercult Ethnopharmacol 17; 6(2), 206-217.
WHO (world health organization). 1996. Fight against hypertension. Expert committee report, technical report series, n°862.
Yasir M, Das S, Kharya MD. 2010. The phytochemical and pharmacological profile of Persea americana Mill. Pharmacogn Rev 4(7), 77-84.
Hourfil-Gabin Ntougou Assoumou, Noreen Orianna Koumba-Madingou, Idensi Bajin Ba Ndob, Gontran Nsi Akoue, Régis Jovin Ndong, Reine Raïssa Rolande Aworet Samseny, Henri-Paul Bourobou (2021), Effects of the aqueous extract of Persea americana Mill (Lauraceae) leaves on the rat isolated aorta: evaluation of vasomotility and acute toxicity; IJBB, V12, N3, June, P1-9
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