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Emerging resistance of antibiotics among various bacterial infections

Research Paper | August 10, 2022

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Syeda Ayesha Ali, Muhammad Kamran Taj, Syeda Hafsa Ali, Safa Farooqi, Ashiq Hussain, Saima Azam, Zaib-Un-Nisa Hanif

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Int. J. Biosci.21( 2), 121-168, August 2022

DOI: http://dx.doi.org/10.12692/ijb/21.2.121-168


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Antibiotics are substances that have a wide range of uses for treating bacterial illnesses. They may be synthetic, naturally occurring, or semi-artificial. The use of antibiotics has enabled the treatment of bacterial infections, saving and enhancing the health of numerous patients around the globe. Antibiotics, however, are not working well enough to stop the spread of infection and the associated mortality rates. However, antibiotic resistance among common community-acquired infections has been on the rise, as has the number of medications to which they are resistant. Data from several researches provide significant evidence that antibiotic use and resistance are interrelated. The highest levels of resistance are found in nations with the highest per capita antibiotic use. Consumption of antimicrobial agents and the prevalence of antibiotic resistance are intricately related. The main causes of resistance are selective antibiotic pressure, the spread of resistant bacteria, and the transfer of resistance genes across bacteria. However, the impact of selective pressure varies depending on the type of bacteria and antibiotic class. The community should refrain from using a lot of antibacterials, especially broad-spectrum antibiotics. When possible, narrow-spectrum penicillins should be employed. Long-term prospective studies that track patterns of antibiotic usage and resistance are required. National measures intended to lessen the resistance of microorganisms to antibiotics should be based on reliable data on antimicrobial consumption and resistance.


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Emerging resistance of antibiotics among various bacterial infections

Aarestrup FM. 1999. Association between the consumption of antimicrobial agents in animal husbandry and the occurrence of resistant bacteria among food animals. International journal of antimicrobial agents 12(4), 279-285. https://doi.org/10.1016/S0924-8579(99)90059-6

Abbanat D, Macielag M, Bush K. 2003. Novel antibacterial agents for the treatment of serious Gram-positive infections. Expert Opinion on Investigational Drugs 12(3), 379-399.

Abraham E, Chain E. 1988. An enzyme from bacteria able to destroy penicillin. 1940. Reviews of infectious diseases 10(4), 677-678.

Acar J. 1997. Broad-and narrow-spectrum antibiotics: an unhelpful categorization. Clinical Microbiology and Infection 3(4), 395-396.

Aggen JB, Armstrong ES, Goldblum AA, Dozzo P, Linsell MS, Gliedt MJ, Matias RD. 2010. Synthesis and spectrum of the neoglycoside ACHN-490. Antimicrobial agents and chemotherapy 54(11), 4636-4642.

Al-Ahmad A, Wiedmann-Al-Ahmad M, Schön G, Daschner FD, Kümmerer K. 2000. Role of Acinetobacter for Biodegradability of Quaternary Ammonium Compounds. Bulletin of Environmental Contamination and Toxicology 64(6), 764-770. https://doi.org/10.1007/s001280000069

Alary M, Joly JR, Mondor M, Moutquin J, Boucher M, Fortier A, Chamberland H. 1994. Randomised comparison of amoxycillin and erythromycin in treatment of genital chlamydial infection in pregnancy. The lancet 344(8935), 1461-1465.

Alborn Jr W, Allen N, Preston D. 1991. Daptomycin disrupts membrane potential in growing Staphylococcus aureus. Antimicrobial agents and chemotherapy 35(11), 2282-2287.

Allen N, Alborn Jr W, Hobbs Jr J. 1991. Inhibition of membrane potential-dependent amino acid transport by daptomycin. Antimicrobial agents and chemotherapy 35(12), 2639-2642.

Allen N, Hobbs J, Alborn Jr W. 1987. Inhibition of peptidoglycan biosynthesis in gram-positive bacteria by LY146032. Antimicrobial agents and chemotherapy 31(7), 1093-1099.

Aminov R. 2011. Horizontal Gene Exchange in Environmental Microbiota. Frontiers in microbiology, 2. https://doi.org/10.3389/fmicb.2011.00158

Aminov RI. 2010. A brief history of the antibiotic era: lessons learned and challenges for the future. Frontiers in microbiology 1, 134.

Aminov RI. 2010. A brief history of the antibiotic era: lessons learned and challenges for the future. Frontiers in microbiology 1, 134.

Andersen SR, Sandaa RA. 1994. Distribution of tetracycline resistance determinants among gram-negative bacteria isolated from polluted and unpolluted marine sediments. Applied and environmental microbiology 60(3), 908-912. https://doi.org/10.1128/aem.60.3.908-912.1994

Andersson DI, Jerlström-Hultqvist J, Näsvall J. 2015. Evolution of new functions de novo and from preexisting genes. Cold Spring Harb Perspect Biol 7(6). https://doi.org/10.1101/cshperspect.a017996

Aoki H, Ke L, Poppe SM, Poel, T J, Weaver EA, Gadwood RC, Ganoza MC. 2002. Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes. Antimicrobial agents and chemotherapy 46(4), 1080-1085.

Ardanuy C, Liñares J, Domínguez MA, Hernández-Allés S, Benedí VJ,  Martínez-Martínez L. 1998. Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems. Antimicrobial agents and chemotherapy 42(7), 1636-1640.

Arias CA, Murray BE. 2009. Antibiotic-resistant bugs in the 21st century—a clinical super-challenge. New England Journal of Medicine 360(5), 439-443.

Armstrong JL, Shigeno DS, Calomiris JJ,  Seidler RJ. 1981. Antibiotic-resistant bacteria in drinking water. Applied and environmental microbiology 42(2), 277-283. https://doi.org/10.1128/aem.42.2.277-283.1981

Bäckman A, Orvelid P, Vazquez JA, Sköld O,  Olcén P. 2000. Complete sequence of a β-lactamase-encoding plasmid in Neisseria meningitidis. Antimicrobial agents and chemotherapy 44(1), 210-212.

BaqueroF, Coque TM, Martínez JL, Aracil-Gisbert S, Lanza VF. 2019. Gene Transmission in the One Health Microbiosphere and the Channels of Antimicrobial Resistance. Frontiers in microbiology, 10. https://doi.org/10.3389/fmicb.2019.02892

Barber M. 1961. Methicillin-resistant staphylococci. Journal of clinical pathology 14(4), 385.

Baucheron S, Tyler S, Boyd D, Mulvey MR, Chaslus-Dancla E, Cloeckaert A. 2004. AcrAB-TolC directs efflux-mediated multidrug resistance in Salmonella enterica serovar Typhimurium DT104. Antimicrobial agents and chemotherapy 48(10), 3729-3735.

Bauer G, Berens, C, Projan SJ, Hillen W. 2004. Comparison of tetracycline and tigecycline binding to ribosomes mapped by dimethylsulphate and drug-directed Fe2+ cleavage of 16S rRNA. Journal of Antimicrobial Chemotherapy 53(4), 592-599.

Baur B, Hanselmann K, Schlimme W, Jenni B. 1996. Genetic transformation in freshwater: Escherichia coli is able to develop natural competence. Applied and environmental microbiology 62(10), 3673-3678. https://doi.org/10.1128/aem.62.10.3673-3678.1996

Beauregard DA, Williams DH, Gwynn MN, Knowles D. 1995. Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics. Antimicrobial agents and chemotherapy 39(3), 781-785.

Becker L, Kaase M, Pfeifer Y, Fuchs S, Reuss A, von Laer A, Werner G. 2018. Genome-based analysis of Carbapenemase-producing Klebsiella pneumoniae isolates from German hospital patients, 2008-2014. Antimicrobial Resistance & Infection Control 7(1), 62. https://doi.org/10.1186/s13756-018-0352-y

Bergeron MG, Brusch JL, Barza M, Weinstein L. 1973. Bactericidal Activity and Pharmacology of Cefazolin. Antimicrobial Agents and Chemotherapy, 4(4), 396-401. https://doi.org/10.1128/AAC.4.4.396

Berglund F, Böhm ME, Martinsson A, Ebmeyer S, Österlund T, Johnning A,  Kristiansson E. 2020. Comprehensive screening of genomic and metagenomic data reveals a large diversity of tetracycline resistance genes. Microbial genomics 6(11), mgen000455. https://doi.org/10.1099/mgen.0.000455

Berglund F, Marathe NP, Österlund T, Bengtsson-Palme J, Kotsakis S, Flach CF, Kristiansson E. 2017. Identification of 76 novel B1 metallo-β-lactamases through large-scale screening of genomic and metagenomic data. Microbiome 5(1), 134. https://doi.org/10.1186/s40168-017-0353-8

Bialek Davenet S, Lavigne JP, Guyot K, Mayer N, Tournebize R, Brisse S, Nicolas Chanoine MH. 2015. Differential contribution of AcrAB and OqxAB efflux pumps to multidrug resistance and virulence in Klebsiella pneumoniae. Journal of Antimicrobial Chemotherapy 70(1), 81-88.

Blanch AR, Caplin JL, Iversen A, Kühn I, Manero A, Taylor HD, Vilanova X. 2003. Comparison of enterococcal populations related to urban and hospital wastewater in various climatic and geographic European regions. Journal of Applied Microbiology 94(6), 994-1002. https://doi.org/10.1046/j.1365-2672.2003.01919.x

Blondeau J.M, DeCarolis E, Metzler KL, Hansen GT. 2002. The macrolides. Expert Opinion on Investigational Drugs 11(2), 189-215.

Bogdanovich T, Bozdogan B, Appelbaum PC. 2006. Effect of Efflux on Telithromycin and Macrolide Susceptibility in <i>Haemophilus influenzae</i>. Antimicrobial Agents and Chemotherapy 50(3), 893-898. https://doi.org/10.1128/AAC.50.3.893-898.2006

Bonnet R. 2004. Growing group of extended-spectrum β-lactamases: the CTX-M enzymes. Antimicrobial agents and chemotherapy 48(1), 1-14.

Boucher HW, Talbot GH, Bradley JS, Edwards JE, Gilbert D, Rice LB, Bartlett J. 2009. Bad bugs, no drugs: no ESKAPE! An update from the Infectious Diseases Society of America. Clinical infectious diseases 48(1), 1-12.

Brandis G, Pietsch F, Alemayehu R, Hughes D. 2015. Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis. Journal of Antimicrobial Chemotherapy 70(3), 680-685.

Brandis G, Pietsch F, Alemayehu R, Hughes D. 2015. Comprehensive phenotypic characterization of rifampicin resistance mutations in Salmonella provides insight into the evolution of resistance in Mycobacterium tuberculosis. Journal of Antimicrobial Chemotherapy 70(3), 680-685.

Brodersen DE, Clemons Jr WM, Carter A P, Morgan Warren RJ, Wimberly BT,  Ramakrishnan V. 2000. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell, 103(7), 1143-1154.

Brogden R, Speight T,  Avery G. 1975. Amoxycillin: A review of its antibacterial and pharmacokinetic properties and therapeutic use. Drugs 9(2), 88-140.

Brueggemann AB, Coffman SL, Rhomberg P, Huynh H, Almer L, Nilius A, Doern GV. 2002. Fluoroquinolone Resistance in <i>Streptococcus pneumoniae</i> in United States since 1994-1995. Antimicrobial agents and chemotherapy 46(3), 680-688. https://doi.org/10.1128/AAC.46.3.680-688.2002

Burchall JJ. 1973. Mechanism of Action of Trimethoprim-Sulfamethoxazole—II. The Journal of infectious diseases 128(3), S437-S441. https://doi.org/10.1093/infdis/128.Supplement_3.S437

Burchall JJ, Hitchings GH. 1965. Inhibitor Binding Analysis of Dihydrofolate Reductases from Various Species. Molecular Pharmacology 1(2), 126.

Burger A. 2003. Medicinal Chemistry and Drug Discovery: Cardiovascular agents and endocrines (3), Wiley.

Burns JL, Mendelman PM, Levy J, Stull  TL,  Smith AL. 1985. A permeability barrier as a mechanism of chloramphenicol resistance in Haemophilus influenzae. Antimicrobial Agents and Chemotherapy 27(1), 46-54. https://doi.org/10.1128/AAC.27.1.46

Canepari P, Boaretti M, Lleo MM, Satta G. 1990. Lipoteichoic acid as a new target for activity of antibiotics: mode of action of daptomycin (LY146032). Antimicrobial agents and chemotherapy, 34(6), 1220-1226.

Cannatelli A, Giani T, D’Andrea MM, Pilato VD, Arena F, Conte V,  Rossolini G M. 2014. MgrB Inactivation Is a Common Mechanism of Colistin Resistance in KPC-Producing Klebsiella pneumoniae of Clinical Origin. Antimicrobial agents and chemotherapy 58(10), 5696-5703. https://doi.org/10.1128/AAC.03110-14

Carbon C, Isturiz R. 2002. Narrow Versus Broad Spectrum Antibacterials. Drugs 62(9), 1289-1294.

Cattoir V, Nordmann P. 2009. Plasmid-mediated quinolone resistance in gram-negative bacterial species: an update. Current medicinal chemistry, 16(8), 1028-1046.

Cejas D, Canigia LF, Cruz GR, Elena AX, Maldonado I, Gutkind GO,  Diekema DJ. 2014. First Isolate of KPC-2-Producing Klebsiella pneumonaie Sequence Type 23 from the Americas. Journal of clinical microbiology 52(9), 3483-3485. https://doi.org/10.1128/JCM.00726-14

Centers of Disease Control and Prevention. 2021. Antibiotic / Antimicrobial Resistance. Retrieved from https://www.cdc.gov/drugresistance/index.html

Champney W. 1999. Macrolide antibiotic inhibition of 50S ribosomal subunit formation in bacterial cells. Recent Res Dev Antimicrob Agents Chemother 3, 39-58.

Champney WS,  Miller M. 2002. Linezolid is a specific inhibitor of 50S ribosomal subunit formation in Staphylococcus aureus cells. Current microbiology, 44(5), 350-356.

Champney WS,  Tober CL. 1998. Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics. Current microbiology 37(6), 418-425.

Champney WS, Tober CL. 1998. Inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells by 11 different ketolide antibiotics. Current microbiology 37(6), 418-425.

Chee-Sanford JC, Aminov RI, Krapac IJ, Garrigues-Jeanjean N, Mackie RI. 2001 Occurrence and Diversity of Tetracycline Resistance Genes in Lagoons and Groundwater Underlying Two Swine Production Facilities. Applied and environmental microbiology 67(4), 1494-1502. https://doi.org/10.1128/AEM.67.4.1494-1502.2001

Chong Y, Shimoda S, Shimono N. 2018. Current epidemiology, genetic evolution and clinical impact of extended-spectrum β-lactamase-producing Escherichia coli and Klebsiella pneumoniae. Infection, Genetics and Evolution 61, 185-188. https://doi.org/10.1016/j.meegid.2018.04.005

Chopra I,  Roberts M. 2001. Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance. Microbiology and Molecular Biology Reviews 65(2), 232-260. https://doi.org/10.1128/MMBR.65.2.232-260.2001

Chopra I,  Roberts M. 2001. Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance. Microbiology and Molecular Biology Reviews 65(2), 232-260. https://doi.org/10.1128/MMBR.65.2.232-260.2001

Coleman K. 2011. Diazabicyclooctanes (DBOs): a potent new class of non-β-lactam β-lactamase inhibitors. Current opinion in microbiology 14(5), 550-555.

Compain F, Vandenberghe A, Gominet M, Genel N, Lebeaux D, Ramahefasolo A, Decré D. 2017. Primary osteomyelitis caused by an NDM-1-producing K. pneumoniae strain of the highly virulent sequence type 23. Emerging Microbes & Infections, 6(1), 1-3. https://doi.org/10.1038/emi.2017.43

Connell SR, Tracz DM, Nierhaus K H, Taylor DE. 2003. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrobial agents and chemotherapy 47(12), 3675-3681.

Connell SR, Tracz DM, Nierhaus K H, Taylor DE. 2003. Ribosomal protection proteins and their mechanism of tetracycline resistance. Antimicrobial agents and chemotherapy 47(12), 3675-3681.

Cornforth DM, Foster KR. 2015. Antibiotics and the art of bacterial war. Proceedings of the national academy of sciences 112(35), 10827-10828.

Couce A, Briales A, Rodríguez-Rojas A, Costas C, Pascual Á,  Blázquez J. 2012. Genomewide overexpression screen for fosfomycin resistance in Escherichia coli: MurA confers clinical resistance at low fitness cost. Antimicrobial agents and chemotherapy 56(5), 2767-2769.

Critchley IA, Draghi DC, Sahm DF, Thornsberry C, Jones ME,  Karlowsky JA. 2003. Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogens collected in the SECURE study (Europe) during 2000–2001. Journal of Antimicrobial Chemotherapy, 51(3), 639-649.

Dabernat H, Delmas C, Seguy, M, Pelissier R, Faucon G, Bennamani S, Pasquier C. 2002. Diversity of &#x3b2;-Lactam Resistance-Conferring Amino Acid Substitutions in Penicillin-Binding Protein 3 of <i>Haemophilus influenzae</i>. Antimicrobial Agents and Chemotherapy 46(7), 2208-2218. https://doi.org/10.1128/AAC.46.7.2208-2218.2002

Dantas G, Sommer MOA, Oluwasegun RD, Church GM. 2008. Bacteria Subsisting on Antibiotics. Science 320(5872), 100-103. https://doi.org/10.1126/science.1155157

Darville T, Yamauchi T. 1994. The cephalosporin antibiotics. Pediatrics in Review 15(2), 54-62.

Davies J, Davies D. 2010. Resistance origins and evolution of antibiotic. Microbiology and Molecular Biology reviews. Microbiology and Molecular Biology Reviews 74(3), 417-433.

Davies J, Davies D. 2010. Resistance origins and evolution of antibiotic. Microbiology and Molecular Biology reviews. Microbiology and Molecular Biology Reviews 74(3), 417-433.

Davis BD. 1987. Mechanism of bactericidal action of aminoglycosides. Microbiological reviews 51(3), 341-350.

Davis BD, Chen L, Tai PC. 1986. Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proceedings of the national academy of sciences 83(16), 6164-6168.

de Groot R, Chaffin DO, Kuehn M,  Smith AL 1991. Trimethoprim resistance in Haemophilus influenzae is due to altered dihydrofolate reductase(s). Biochemical Journal 274(3), 657-662. https://doi.org/10.1042/bj2740657

De Liguoro M, Cibin V, Capolongo F, Halling-Sørensen B, Montesissa. 2003. Use of oxytetracycline and tylosin in intensive calf farming: evaluation of transfer to manure and soil. Chemosphere 52(1), 203-212. https://doi.org/10.1016/S0045-6535(03)00284-4

Deeks SL, Palacio R, Ruvinsky Rl, Kertesz DA, Hortal M, Rossi A, Group SpW. 1999. Risk factors and course of illness among children with invasive penicillin-resistant Streptococcus pneumoniae. Pediatrics 103(2), 409-413.

D’Elios MM, Amedei A, Manghetti M, Costa  F, Baldari CT, Quazi AS, del Prete G. 1999. Impaired T-cell regulation of B-cell growth in Helicobacter pylori–related gastric low-grade MALT lymphoma. Gastroenterology 117(5), 1105-1112.

Discotto L, Lawrence L, Denbleyker K, Barrett J. 2001. Staphylococcus aureus mutants selected by BMS-284756. Antimicrobial agents and chemotherapy 45(11), 3273-3275.

Doherty N, Trzcinski K, Pickerill P, Zawadzki P, Dowson, CG. 2000. Genetic Diversity of the <i>tet</i>(M) Gene in Tetracycline-Resistant Clonal Lineages of <i>Streptococcus pneumoniae</i>. Antimicrobial agents and chemotherapy 44(11), 2979-2984. https://doi.org/10.1128/AAC.44.11.2979-2984.2000

Dong N, Yang X, Zhang R, Chan EWC, Chen S. 2018. Tracking microevolution events among ST11 carbapenemase-producing hypervirulent Klebsiella pneumoniae outbreak strains. Emerging Microbes & Infections 7(1), 1-8. https://doi.org/10.1038/s41426-018-0146-6

Dönhöfer A, Franckenberg S, Wickles S, Berninghausen Beckmann R,  Wilson DN. 2012. Structural basis for TetM-mediated tetracycline resistance. Proceedings of the national academy of sciences 109(42), 16900-16905.

Donowitz GR, Mandell GL 1988. Beta-lactam antibiotics. New England Journal of Medicine, 318(7), 419-426.

Douthwaite S. 2001. Structure–activity relationships of ketolides vs. macrolides. Clinical Microbiology and Infection 7, 11-17.

Douthwaite S, Aagaard C. 1993. Erythromycin binding is reduced in ribosomes with conformational alterations in the 23 S rRNA peptidyl transferase loop. Journal of molecular biology 232(3), 725-731.

Douthwaite S, Champney WS. 2001. Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site. Journal of Antimicrobial Chemotherapy 48(2), 1-8.

Douthwaite S, Hansen LH, Mauvais P. 2000. Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA. Molecular microbiology, 36(1), 183-193.

Dowell SF, Butler JC, GIEBINK GS, Jacobs MR, JERNIGAN D, MUSHER DM,   SCHWARTZ B. 1999. Acute otitis media: management and surveillance in an era of pneumococcal resistance-a report from the Drug-resistant Streptococcus pneumoniae Therapeutic Working Group. The Pediatric infectious disease journal 18(1), 1-9.

Drlica K,  Zhao X. 1997. DNA gyrase, topoisomerase IV, and the 4-quinolones. Microbiology and Molecular Biology Reviews 61(3), 377-392.

DuPont HL, Steele JH. 1987. Use of Antimicrobial Agents in Animal Feeds: Implications for Human Health. Reviews of infectious diseases 9(3), 447-460. https://doi.org/10.1093/clinids/9.3.447

Edwards RA, Puente JL. 1998. Fimbrial expression in enteric bacteria: a critical step in intestinal pathogenesis. Trends in microbiology 6(7), 282-287.

Eickhoff TC, Finland M,  Wilcox C. 1965. Changing susceptibility of meningococci to antimicrobial agents. New England Journal of Medicine 272(8), 395-398.

Eliopoulos GM, Huovinen P. 2001. Resistance to Trimethoprim-Sulfamethoxazole. Clinical infectious diseases 32(11), 1608-1614. https://doi.org/10.1086/320532

Esnault C, Dulermo T, Smirnov A, Askora A, David M, Deniset-Besseau A, Virolle MJ. 2017. Strong antibiotic production is correlated with highly active oxidative metabolism in Streptomyces coelicolor M145. Scientific reports 7(1), 1-10.

Esteban FM, Delia B, Iren EG,  Campa A. 2000. Fluoroquinolones Inhibit Preferentially Streptococcus pneumoniae DNA Topoisomerase IV Than DNA Gyrase Native Proteins. Microbial Drug Resistance 6(4), 259-267. https://doi.org/10.1089/mdr.2000.6.259

Falagas ME, Kasiakou SK, Saravolatz LD. 2005. Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clinical infectious diseases, 40(9), 1333-1341.

Farrell DJ, Morrissey I, Bakker S, Buckridge S, Felmingham D. 2005. Global distribution of TEM-1 and ROB-1 β-lactamases in Haemophilus influenzae. Journal of Antimicrobial Chemotherapy, 56(4), 773-776. https://doi.org/10.1093/jac/dki281

Feng Y, LuY, Yao Z,  Zong  Z. 2018. Carbapenem-Resistant Hypervirulent Klebsiella pneumoniae of Sequence Type 36. Antimicrobial agents and chemotherapy 62(7), e02644-02617. https://doi.org/10.1128/AAC.02644-17

Fermer C, Kristiansen BE, Sköld O,  Swedberg G. 1995. Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species. Journal of bacteriology 177(16), 4669-4675. https://doi.org/10.1128/jb.177.16.4669-4675.1995

Feßler AT, Kadlec K, Schwarz S. 2011. Novel apramycin resistance gene apmA in bovine and porcine methicillin-resistant Staphylococcus aureus ST398 isolates. Antimicrobial agents and chemotherapy 55(1), 373-375.

Finland M, Frank PF, Wilcox C. 1950. In vitro Susceptibility of Pathogenic Staphylococci to Seven Antibiotics. (Penicillin, Streptomycin, Bacitracin, Polymyxin, Aerosporin, Aureomyein and Chloromycetin). With a Note on the Changing Resistance of Staphylococci to Penicillin. American Journal of Clinical Pathology 20(4), 325-334.

Fisher JF, Meroueh SO, Mobashery S. 2005. Bacterial resistance to β-lactam antibiotics: compelling opportunism, compelling opportunity. Chemical reviews 105(2), 395-424.

Flach CF, Pal C, Svensson CJ, Kristiansson E, Östman M, Bengtsson-Palme J, Larsson DG J. 2017. Does antifouling paint select for antibiotic resistance? Science of the total environment 590-591, 461-468. https://doi.org/10.1016/j.scitotenv.2017.01.213

Fleming A. 1929. On the antibacterial action of cultures of a penicillium, with special reference to their use in the isolation of B. influenzae. British journal of experimental pathology 10(3), 226.

Flexner S. 1913. The results of the serum treatment in thirteen hundred cases of epidemic meningitis. The Journal of experimental medicine 17(5), 553-576.

Floss HG, Yu TW. 2005. Rifamycin mode of action, resistance, and biosynthesis. Chemical reviews 105(2), 621-632.

Forsberg KJ, Reyes A, Wang B, Selleck EM, Sommer MOA, Dantas G. 2012. The Shared Antibiotic Resistome of Soil Bacteria and Human Pathogens. Science 337(6098), 1107-1111. https://doi.org/10.1126/science.1220761

Fourmy D, Yoshizawa S, Puglisi JD. 1998. Paromomycin binding induces a local conformational change in the A-site of 16 S rRNA. Journal of molecular biology 277(2), 333-345.

Fredrickson JK, Hicks RJ,  Li SW,  Brockman FJ. 1988. Plasmid Incidence in Bacteria from Deep Subsurface Sediments. Applied and environmental microbiology 54(12), 2916-2923. https://doi.org/10.1128/aem.54.12.2916-2923.1988

Galimand M, Gerbaud G, Guibourdenche M, Riou JY, Courvalin P. 1998. High-level chloramphenicol resistance in Neisseria meningitidis. New England Journal of Medicine 339(13), 868-874.

Garoff L, Yadav K, Hughes D. 2018. Increased expression of Qnr is sufficient to confer clinical resistance to ciprofloxacin in Escherichia coli. Journal of Antimicrobial Chemotherapy 73(2), 348-352.

Garza-Ramos G, Xiong L, Zhong P, Mankin A. 2001. Binding site of macrolide antibiotics on the ribosome: new resistance mutation identifies a specific interaction of ketolides with rRNA. Journal of bacteriology 183(23), 6898-6907.

Gavalchin J, Katz SE. 2020. The Persistence of Fecal-Borne Antibiotics in Soil. Journal of AOAC International 77(2), 481-485. https://doi.org/10.1093/jaoac/77.2.481

Ge M, Chen Z, Russell H, Onishi Kohler J, Silver LL, Kahne D. 1999. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding D-Ala-D-Ala. Science 284(513), 507-511.

George LL, Borody TJ, Andrews P, Devine M, MooreJones D, Walton M, Brandi S. 1990. Cure of duodenal ulcer after eradication of Helicobacter pylori. Medical Journal of Australia, 153(3), 145-149.

Giamarellou H. 2006. Treatment options for multidrug-resistant bacteria. Expert review of anti-infective therapy 4(4), 601-618.

Gillings M, Boucher Y, Labbate M, Holmes A, Krishnan S, Holley M, Stokes H. 2008. The Evolution of Class 1 Integrons and the Rise of Antibiotic Resistance. Journal of bacteriology, 190(14), 5095-5100. https://doi.org/10.1128/JB.00152-08

Gnanamani A, Hariharan P, Paul-Satyaseela M. 2017. Staphylococcus aureus: Overview of bacteriology, clinical diseases, epidemiology, antibiotic resistance and therapeutic approach. Frontiers in Staphylococcus aureus 4, 28.

Goh EB, Yim G, Tsui W, McClure J, Surette G, Davies J. 2002. Transcriptional modulation of bacterial gene expression by subinhibitory concentrations of antibiotics. Proceedings of the national academy of sciences 99(26), 17025-17030.

Gold HS, Moellering Jr RC. 1996. Antimicrobial-drug resistance. New England Journal of Medicine, 335(19), 1445-1453.

Golet EM, Strehler A, Alder AC, Giger W. 2002. Determination of Fluoroquinolone Antibacterial Agents in Sewage Sludge and Sludge-Treated Soil Using Accelerated Solvent Extraction Followed by Solid-Phase Extraction. Analytical Chemistry, 74(21), 5455-5462. https://doi.org/10.1021/ac025762m

Goñi-Urriza M, Pineau L, Capdepuy M, Roques C, Caumette P, Quentin C. 2000. Antimicrobial resistance of mesophilic Aeromonas spp. isolated from two European rivers. Journal of Antimicrobial Chemotherapy 46(2), 297-301. https://doi.org/10.1093/jac/46.2.297

Gotz A, Smalla K. 1997. Manure Enhances Plasmid Mobilization and Survival of Pseudomonas putida Introduced into Field Soil. Applied and environmental microbiology 63(5), 1980-1986. https://doi.org/10.1128/aem.63.5.1980-1986.1997

Griffey RH, Hofstadler SA, Sannes-Lowery KA, Ecker DJ, Crooke ST. 1999. Determinants of aminoglycoside-binding specificity for rRNA by using mass spectrometry. Proceedings of the national academy of sciences 96(18), 10129-10133.

Gu D, Dong N, Zheng Z, Lin D, Huang M, Wang L, Chen S. 2018. A fatal outbreak of ST11 carbapenem-resistant hypervirulent Klebsiella pneumoniae in a Chinese hospital: a molecular epidemiological study. The Lancet infectious diseases, 18(1), 37-46. https://doi.org/10.1016/S1473-3099(17)30489-9

Hamscher G, Sczesny S, Höper H, Nau H. 2002. Determination of Persistent Tetracycline Residues in Soil Fertilized with Liquid Manure by High-Performance Liquid Chromatography with Electrospray Ionization Tandem Mass Spectrometry. Analytical Chemistry 74(7), 1509-1518. https://doi.org/10.1021/ac015588m

Hancock RE. 1984. Alterations in outer membrane permeability. Annual review of microbiology 38(1), 237-264.

Hancock R, Farmer SW, Li Z, Poole K. 1991. Interaction of aminoglycosides with the outer membranes and purified lipopolysaccharide and OmpF porin of Escherichia coli. Antimicrobial agents and chemotherapy 35(7), 1309-1314.

Hancock R, Raffle VJ, Nicas TI. 1981. Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy, 19(5), 777-785.

Hansen LH, Mauvais P, Douthwaite S. 1999. The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA. Molecular microbiology 31(2), 623-631.

Hartman-Neumann S, DenBleyker K, Pelosi L A, Lawrence LE, Barrett JF, Dougherty TJ. 2001. Selection and genetic characterization of Streptococcus pneumoniae mutants resistant to the des-F (6) quinolone BMS-284756. Antimicrobial agents and chemotherapy 45(10), 2865-2870.

Harwood VJ, Brownell M, Perusek W,  Whitlock JE. 2001. Vancomycin-Resistant <i>Enterococcus</i> spp. Isolated from Wastewater and Chicken Feces in the United States. Applied and environmental microbiology 67(10), 4930-4933. https://doi.org/10.1128/AEM.67.10.4930-4933.2001

Heaton VJ, Ambler JE, Fisher LM. 2000. Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro. Antimicrobial agents and chemotherapy 44(11), 3112-3117.

Heaton VJ, Ambler JE, Fisher LM. 2000. Potent antipneumococcal activity of gemifloxacin is associated with dual targeting of gyrase and topoisomerase IV, an in vivo target preference for gyrase, and enhanced stabilization of cleavable complexes in vitro. Antimicrobial agents and chemotherapy 44(11), 3112-3117.

Hebeisen P, Heinze-Krauss I, Angehrn P, Hohl P, Page MG, Then RL. 2001. In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci. Antimicrobial agents and chemotherapy 45(3), 825-836.

Heisig P,  Tschorny R. 1994. Characterization of fluoroquinolone-resistant mutants of Escherichia coli selected in vitro. Antimicrobial agents and chemotherapy 38(6), 1284-1291.

Hendlin D, Stapley E, Jackson M, Wallick H, Miller A, Wolf F, Foltz E. 1969. Phosphonomycin, a new antibiotic produced by strains of Streptomyces. Science 166(3901), 122-123.

Hernández-Allés S, Albertí S, Álvarez D, Doménech-Sánchez A, Martínez-Martínez, L, Gil J, Benedí VJ. 1999. Porin expression in clinical isolates of Klebsiella pneumoniae. Microbiology, 145(3), 673-679.

Heuer H, Krögerrecklenfort E, Wellington EMH, Egan S, van Elsas JD, Van Overbeek L, Smalla K. 2002. Gentamicin resistance genes in environmental bacteria: prevalence and transfer. FEMS Microbiology Ecology 42(2), 289-302. https://doi.org/10.1111/j.1574-6941.2002.tb01019.x

Hingst V, Klippel KM, Sonntag HG. 1995. [Epidemiology of microbial resistance to biocides]. Zentralblatt fur Hygiene und Umweltmedizin = International journal of hygiene and environmental medicine 197(1-3), 232-251.

Hitchings GH. 1973. Mechanism of Action of Trimethoprim-Sulfamethoxazole—I. The Journal of infectious diseases, 1283), S433-S436. https://doi.org/10.1093/infdis/128.Supplement_3.S433

Hof H. 1994. Macrolides, a group of antibiotics with a broad spectrum of activity. Immunitat und Infektion 22(2), 66-71.

Holmes A, Moore L, Sundsfjord A, Steinba M, Regmi S. 2016. Kar ey A., Guerin PJ and Piddoc LJV Understanding the mechanisms and drivers of antimicrobial resistance. Lancet 387, 176-187.

Hooper DC. 2000. Mechanisms of action and resistance of older and newer fluoroquinolones. Clinical infectious diseases 31(2), S24-S28.

Hooper DC. 2003. Mechanisms of quinolone resistance. Quinolone antimicrobial agents, 41-67.

Hopkins KL, Davies RH,  Threlfall EJ. 2005. Mechanisms of quinolone resistance in Escherichia coli and Salmonella: recent developments. International journal of antimicrobial agents 25(5), 358-373.

Hotomi M, Fujihara K, Billal DS, Suzuki K, Nishimura T, Baba S,  Yamanaka N. 2007. Genetic Characteristics and Clonal Dissemination of &#x3b2;-Lactamase-Negative Ampicillin-Resistant <i>Haemophilus influenzae</i> Strains Isolated from the Upper Respiratory Tract of Patients in Japan. Antimicrobial Agents and Chemotherapy, 51(11), 3969-3976. https://doi.org/10.1128/AAC.00422-07

Hsieh WC, Ho SW. 1975. Evaluation of antibacterial activities of cephalosporin antibiotics: cefazolin, cephaloridine, cephalothin, and cephalexin. Zhonghua Minguo wei sheng wu xue za zhi = Chinese journal of microbiology 8(1), 1-11.

Huang JQ, Sridhar S, Chen Y,  Hunt RH. 1998. Meta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer. Gastroenterology 114(6), 1169-1179.

Huang YH, Chou SH, Liang SW, Ni CE, Lin YT, Huang YW,  Yang TC. 2018. Emergence of an XDR and carbapenemase-producing hypervirulent Klebsiella pneumoniae strain in Taiwan. Journal of Antimicrobial Chemotherapy 73(8), 2039-2046. https://doi.org/10.1093/jac/dky164

Hutchinson DK. 2003. Oxazolidinone antibacterial agents: a critical review. Current topics in medicinal chemistry 3(9), 1021-1042.

Ito T, Katayama Y, Hiramatsu K. 1999. Cloning and nucleotide sequence determination of the entire mec DNA of pre-methicillin-resistant Staphylococcus aureus N315. Antimicrobial agents and chemotherapy 43(6), 1449-1458.

Iversen A, Kühn I, Franklin A, Möllby R. 2002. High Prevalence of Vancomycin-Resistant Enterococci in Swedish Sewage. Applied and environmental microbiology 68(6), 2838-2842. https://doi.org/10.1128/AEM.68.6.2838-2842.2002

Jarvis W R, Schlosser J, Chinn R Y, Tweeten S, Jackson M. 2007. National prevalence of methicillin-resistant Staphylococcus aureus in inpatients at US health care facilities, 2006. American journal of infection control 35(10), 631-637.

Jenkins SG, Brown SD, Farrell DJ. 2008. Trends in antibacterial resistance among Streptococcus pneumoniae isolated in the USA: update from PROTEKT US Years 1–4. Annals of Clinical Microbiology and Antimicrobials 7(1), 1. https://doi.org/10.1186/1476-0711-7-1

Jensen LB, Baloda S, Boye M, Aarestrup FM. 2001. Antimicrobial resistance among Pseudomonas spp. and the Bacillus cereus group isolated from Danish agricultural soil. Environment international, 26(7), 581-587. https://doi.org/10.1016/S0160-4120(01)00045-9

Jung D, Rozek A, Okon M, Hancock RE. 2004. Structural transitions as determinants of the action of the calcium-dependent antibiotic daptomycin. Chemistry & biology 11(7), 949-957.

Jutkina J, Marathe NP, Flach CF, Larsson DGJ. 2018. Antibiotics and common antibacterial biocides stimulate horizontal transfer of resistance at low concentrations. Science of the total environment, 616-617, 172-178. https://doi.org/10.1016/j.scitotenv.2017.10.312

Kadlec K, Schwarz S. 2009. Novel ABC transporter gene, vga (C), located on a multiresistance plasmid from a porcine methicillin-resistant Staphylococcus aureus ST398 strain. Antimicrobial agents and chemotherapy 53(8), 3589-3591.

Kahan FM, Kahan J S, Cassidy PJ, Kropp H. 1974. The mechanism of action of fosfomycin (phosphonomycin). Annals of the New York Academy of Sciences 235(1), 364-386.

Kaplan SL, Mason Jr EO. 1998. Management of infections due to antibiotic-resistant Streptococcus pneumoniae. Clinical microbiology reviews 11(4), 628-644.

Katayama Y, Ito T, Hiramatsu K. 2000. A new class of genetic element, staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus. Antimicrobial agents and chemotherapy 44(6), 1549-1555.

Keeney D, Ruzin A, McAleese F, Murphy E,  Bradford PA. 2008. MarA-mediated overexpression of the AcrAB efflux pump results in decreased susceptibility to tigecycline in Escherichia coli. Journal of Antimicrobial Chemotherapy 61(1), 46-53.

Kelley TR, Pancorbo OC, Merka WC,  Barnhart HM. 1998. Antibiotic resistance of bacterial litter isolates. Poultry Science 77(2), 243-247. https://doi.org/10.1093/ps/77.2.243

Kimura M,  Ohta T. 1969. The Average Number of Generations until Fixation of a Mutant Gene in a Finite Population. Genetics 61(3), 763-771. https://doi.org/10.1093/genetics/61.3.763

King DE, Malone R, Lilley SH. 2000. New classification and update on the quinolone antibiotics. American family physician 61(9), 2741-2748.

Kislak JW. 1972. The susceptibility of Bacteroides fragilis to 24 antibiotics. Journal of Infectious Diseases 125(3), 295-299.

Klein NC, Cunha BA. 1995. Third-generation cephalosporins. Med Clin North Am 79(4), 705-719. https://doi.org/10.1016/s0025-7125(16)30034-7

Knöppel A, Näsvall J, Andersson DI. 2017. Evolution of Antibiotic Resistance without Antibiotic Exposure. Antimicrobial agents and chemotherapy, 61(11), e01495-01417. https://doi.org/10.1128/AAC.01495-17

Kothari C, Gaind R, Singh LC, Sinha A, Kumari V, Arya S, Deb M. 2013. Community acquisition of β-lactamase producing Enterobacteriaceae in neonatal gut. BMC microbiology 13(1), 1-6.

Kotra LP, Haddad J, Mobashery S. 2000. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. Antimicrobial agents and chemotherapy, 44(12), 3249-3256.

Kotra LP, Haddad J, Mobashery S. 2000. Aminoglycosides: perspectives on mechanisms of action and resistance and strategies to counter resistance. Antimicrobial agents and chemotherapy, 44(12), 3249-3256.

Kümmerer K. 2001. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources – a review. Chemosphere 45(6), 957-969. https://doi.org/10.1016/S0045-6535(01)00144-8

Kümmerer K, Henninger A. 2003. Promoting resistance by the emission of antibiotics from hospitals and households into effluent. Clinical Microbiology and Infection 9(12), 1203-1214. https://doi.org/10.1111/j.1469-0691.2003.00739.x

Lakey JH,  Lea EJ. 1986. The role of acyl chain character and other determinants on the bilayer activity of A21978C an acidic lipopeptide antibiotic. Biochimica et Biophysica Acta (BBA)-Biomembranes, 859(2), 219-226.

Lakey JH, Ptak M. 1988. Fluorescence indicates a calcium-dependent interaction between the lipopeptide antibiotic LY 146032 and phospholipid membranes. Biochemistry 27(13), 4639-4645.

Lancet T. 2009. Urgently needed: new antibiotics 374, p 1868, Elsevier.

Landman D, Babu E, Shah N, Kelly P, Bäcker M, Bratu S, Quale J. 2010. Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City. Journal of Antimicrobial Chemotherapy 65(10), 2123-2127.

Lee W, McDonough MA, Kotra LP, LiZH, Silvaggi NR, Takeda Y, Mobashery S. 2001. A 1.2-Å snapshot of the final step of bacterial cell wall biosynthesis. Proceedings of the National Academy of Sciences 98(4), 1427-1431.

Letten AD, Hall AR, Levine JM. 2021. Using ecological coexistence theory to understand antibiotic resistance and microbial competition. Nature Ecology & Evolution 5(4), 431-441. https://doi.org/10.1038/s41559-020-01385-w

Levy SB. 2001. Antibiotic Resistance: Consequences of Inaction. Clinical infectious diseases 33(3), S124-S129. https://doi.org/10.1086/321837

Li J, Nation RL. 2006. Old polymyxins are back: is resistance close? Clinical infectious diseases 43(5), 663-664.

Li XZ, Plésiat P, Nikaido H. 2015. The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria. Clinical microbiology reviews, 28(2), 337-418.

Lim S, Bast D, McGeer A, de Azavedo J, Low DE. 2003. Antimicrobial susceptibility breakpoints and first-step parC mutations in Streptococcus pneumoniae: redefining fluoroquinolone resistance. Emerging infectious diseases 9(7), 833-837. https://doi.org/10.3201/eid0907.020589

Lin AH, Murray RW, Vidmar TJ, Marotti KR. 1997. The oxazolidinone eperezolid binds to the 50S ribosomal subunit and competes with binding of chloramphenicol and lincomycin. Antimicrobial agents and chemotherapy 41(10), 2127-2131.

Lin E. 1976. Glycerol dissimilation and its regulation in bacteria. Annual review of microbiology 30(1), 535-578.

Linares JF, Gustafsson I, Baquero F, Martinez J. 2006. Antibiotics as intermicrobial signaling agents instead of weapons. Proceedings of the national academy of sciences 103(51), 19484-19489.

Linden PK. 2002. Treatment options for vancomycin-resistant enterococcal infections. Drugs, 62(3), 425-441.

Liu YY, Wang Y, Walsh TR, Yi LX, Zhang R, Spencer J, Huang X. 2016. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. The Lancet infectious diseases 16(2), 161-168.

Llano-Sotelo B, Hickerson RP, Lancaster L, Noller HF, Mankin AS. 2009. Fluorescently labeled ribosomes as a tool for analyzing antibiotic binding. Rna, 15(8), 1597-1604.

Lopez P, Espinosa M, Greenberg B, Lacks SA. 1987. Sulfonamide resistance in Streptococcus pneumoniae: DNA sequence of the gene encoding dihydropteroate synthase and characterization of the enzyme. Journal of bacteriology 169(9), 4320-4326. https://doi.org/10.1128/jb.169.9.4320-4326.1987

Lorber B. 1997. Listeriosis. Clinical Infectious Diseases 24(1), 1-11. https://doi.org/10.1093/clinids/24.1.1

Lorenz MG, Wackernagel W. 1994. Bacterial gene transfer by natural genetic transformation in the environment. Microbiological reviews 58(3), 563 https://doi.org/10.1128/mr.58.3.563-602.1994

Lowy FD. 1998. Staphylococcus aureus infections. New England Journal of Medicine 339(8), 520-532.

Lupo A, Saras E, Madec JY, Haenni M. 2018. Emergence of bla CTX-M-55 associated with fosA, rmtB and mcr gene variants in Escherichia coli from various animal species in France. Journal of Antimicrobial Chemotherapy 73(4), 867-872.

Magiorakos AP, Srinivasan A, Carey RB, Carmeli Y, Falagas M, Giske C, Olsson-Liljequist B. 2012. Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical Microbiology and Infection 18(3), 268-281.

Maiden MC. 1998. Horizontal genetic exchange, evolution, and spread of antibiotic resistance in bacteria. Clinical infectious diseases 27(1), S12-S20.

Maiti SN, Phillips OA, Micetich RG, Livermore DM. 1998. Beta-lactamase inhibitors: agents to overcome bacterial resistance. Current medicinal chemistry 5(6), 441-456.

Malabarba A, Ciabatti R. 2001. Glycopeptide derivatives. Current medicinal chemistry 8(14), 1759-1773.

Malouin F, Blais J, Chamberland S, Hoang M, Park C, Chan C, Liu E. 2003. RWJ-54428 (MC-02,479), a new cephalosporin with high affinity for penicillin-binding proteins, including PBP 2a, and stability to staphylococcal beta-lactamases. Antimicrobial agents and chemotherapy 47(2), 658-664.

Marcinek H, Wirth R, Muscholl-Silberhorn A, Gauer M. 1998. <i>Enterococcus faecalis</i> Gene Transfer under Natural Conditions in Municipal Sewage Water Treatment Plants. Applied and environmental microbiology 64(2), 626-632. https://doi.org/10.1128/AEM.64.2.626-632.1998

Marcusson LL, Frimodt-Møller N, Hughes D. 2009. Interplay in the selection of fluoroquinolone resistance and bacterial fitness. PLoS pathogens, 5(8), e1000541.

Marengo JR, Kok RA, O’Brien K, Velagaleti RR, Stamm JM. 1997. Aerobic biodegradation of (14C)-sarafloxacin hydrochloride in soil. Environmental Toxicology and Chemistry 16(3), 462-471. https://doi.org/10.1002/etc.5620160311

Marques AM, Congregado F, Simonpujol DM. 1979. Antibiotic and Heavy Metal Resistance of Pseudomonas aeruginosa Isolated from Soils. Journal of Applied Bacteriology 47(2), 347-350. https://doi.org/10.1111/j.1365-2672.1979.tb01765.x

Martin WJ, Gardner M, Washington JA. 1972. In vitro antimicrobial susceptibility of anaerobic bacteria isolated from clinical specimens. Antimicrobial agents and chemotherapy 1(2), 148-158.

Matsuo M, Cui L, Kim J, Hiramatsu K. 2013. Comprehensive identification of mutations responsible for heterogeneous vancomycin-intermediate Staphylococcus aureus (hVISA)-to-VISA conversion in laboratory-generated VISA strains derived from hVISA clinical strain Mu3. Antimicrobial agents and chemotherapy 57(12), 5843-5853.

McKeon DM, Calabrese JP, Bissonnette GK. 1995. Antibiotic resistant gram-negative bacteria in rural groundwater supplies. Water Research 29(8), 1902-1908. https://doi.org/10.1016/0043-1354(95)00013-B

McNicol LA, Aziz KM, Huq I, Kaper JB, Lockman HA, Remmers EF, Colwell RR. 1980. Isolation of drug-resistant Aeromonas hydrophila from aquatic environments. Antimicrobial agents and chemotherapy 17(3), 477-483. https://doi.org/10.1128/AAC.17.3.477

Mena A, Plasencia V, García L, Hidalgo O, Ayestarán JI, Alberti S, Oliver A. 2006. Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development. Journal of clinical microbiology, 44(8), 2831-2837.

Menninger JR. 1995. Mechanism of inhibition of protein synthesis by macrolide and lincosamide antibiotics. Journal of basic and clinical physiology and pharmacology 6(3-4), 229-250.

Michael GB, Freitag C, Wendlandt S, Eidam C, Feßler AT, Lopes, GV, Schwarz S. 2015. Emerging issues in antimicrobial resistance of bacteria from food-producing animals. Future Microbiology 10(3), 427-443. https://doi.org/10.2217/fmb.14.93

Miller WR, Munita JM, Arias CA. 2014. Mechanisms of antibiotic resistance in enterococci. Expert review of anti-infective therapy 12(10), 1221-1236.

Mingeot-Leclercq MP, Glupczynski Y, Tulkens PM. 1999. Aminoglycosides: activity and resistance. Antimicrobial agents and chemotherapy 43(4), 727-737.

Morar M, Wright GD. 2010. The Genomic Enzymology of Antibiotic Resistance. Annual Review of Genetics 44(1), 25-51. https://doi.org/10.1146/annurev-genet-102209-163517

Morgan RC, Guerry P, Colwell RR. 1976. Antibiotic resistant bacteria in Chesapeake Bay. Chesapeake Science 17(3), 216-219. https://doi.org/10.2307/1351201

Morrissey I, George J. 1999. Activities of fluoroquinolones against Streptococcus pneumoniae type II topoisomerases purified as recombinant proteins. Antimicrobial agents and chemotherapy, 43(11), 2579-2585.

Morrissey I, George JT. 2000. Purification of pneumococcal type II topoisomerases and inhibition by gemifloxacin and other quinolones. Journal of Antimicrobial Chemotherapy 45(3), 101-101.

Muela A, Pocino M, Arana I, Justo JI, Iriberri J, Barcina I. 1994. Effect of growth phase and parental cell survival in river water on plasmid transfer between Escherichia coli strains. Applied and environmental microbiology 60(12), 4273-4278. https://doi.org/10.1128/aem.60.12.4273-4278.1994

Mulligan ME, Murray-Leisure KA, Ribner BS, Standiford HC, JohnJF, Korvick JA, Victor LY. 1993. Methicillin-resistant Staphylococcus aureus: a consensus review of the microbiology, pathogenesis, and epidemiology with implications for prevention and management. The American journal of medicine 94(3), 313-328.

Nazir J, Urban C, Mariano N, Burns J, Tommasulo B, Rosenber C, Rahal JJ. 2004. Quinolone-Resistant Haemophilus influenzae in a Long-Term Care Facility: Clinical and Molecular Epidemiology. Clinical Infectious Diseases 38(11), 1564-1569. https://doi.org/10.1086/420820

Nichols WW, Young SN. 1985. Respiration-dependent uptake of dihydrostreptomycin by Escherichia coli. Its irreversible nature and lack of evidence for a uniport process. Biochemical Journal, 228(2), 505-512.

Niederman MS. 2015. Macrolide-Resistant Pneumococcus in Community-acquired Pneumonia. Is There Still a Role for Macrolide Therapy? American Journal of Respiratory and Critical Care Medicine, 191(11), 1216-1217. https://doi.org/10.1164/rccm.201504-0701ED

Nikaido H. 2001. Preventing drug access to targets: cell surface permeability barriers and active efflux in bacteria. Paper presented at the Seminars in cell & developmental biology.

Nikaido H. 2003. Molecular basis of bacterial outer membrane permeability revisited. Microbiology and Molecular Biology Reviews 67(4), 593-656.

Nikaido H. 2009. Multidrug resistance in bacteria. Annual review of biochemistry 78, 119-146.

Nolte O. 1997. Rifampicin resistance in Neisseria meningitidis: evidence from a study of sibling strains, description of new mutations and notes on population genetics. The Journal of antimicrobial chemotherapy, 39(6), 747-755.

Okamoto MP, Nakahiro RK, Chin A, Bedikian A, Gill MA. 1994. Cefepime: A new fourth-generation cephalosporin. American Journal of Hospital Pharmacy 51(4), 463-477. https://doi.org/10.1093/ajhp/51.4.463

Oloke J. 2000. Activity pattern of natural and synthetic antibacterial agents among hospital isolates. Microbios 102(403), 175-181.

Olson MW, Ruzin A, Feyfant E, Rush III TS, O’Connell J, Bradford PA. 2006. Functional, biophysical, and structural bases for antibacterial activity of tigecycline. Antimicrobial agents and chemotherapy 50(6), 2156-2166.

Onodera Y, Uchida Y, Tanaka M, Sato K. 1999. Dual inhibitory activity of sitafloxacin (DU-6859a) against DNA gyrase and topoisomerase IV of Streptococcus pneumoniae. Journal of Antimicrobial Chemotherapy, 44(4), 533-536.

Oppenheim BA. 1997. Antibiotic resistance in Neisseria meningitidis. Clinical infectious diseases, 24(1), S98-S101.

Pang Y, Brown BA, Steingrube VA, Wallace RJ, Roberts MC. 1994. Tetracycline resistance determinants in Mycobacterium and Streptomyces species. Antimicrobial agents and chemotherapy, 38(6), 1408-1412. https://doi.org/10.1128/AAC.38.6.1408

Partridge SR, Kwong SM, Firth N, Jensen SO. 2018. Mobile Genetic Elements Associated with Antimicrobial Resistance. Clinical microbiology reviews 31(4), e00088-00017. https://doi.org/10.1128/CMR.00088-17

Pawlowski AC, Wang W, Koteva K, Barton HA, McArthur AG, Wright GD. 2016. A diverse intrinsic antibiotic resistome from a cave bacterium. Nature communications 7(1), 13803. https://doi.org/10.1038/ncomms13803

Peric M, Bozdogan B, Galderisi C, Krissinger D, Rager T,  Appelbaum PC. 2004. Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-S. Journal of Antimicrobial Chemotherapy 54(2), 393-400. https://doi.org/10.1093/jac/dkh364

Peric M, Bozdogan B, Jacobs MR, Appelbaum PC. 2003. Effects of an Efflux Mechanism and Ribosomal Mutations on Macrolide Susceptibility of <i>Haemophilus influenzae</i> Clinical Isolates. Antimicrobial Agents and Chemotherapy 47(3), 1017-1022. https://doi.org/10.1128/AAC.47.3.1017-1022.2003

Piddock LJ, Jin YF, Ricci V, Asuquo AE. 1999. Quinolone accumulation by Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli. Journal of Antimicrobial Chemotherapy 43(1), 61-70.

Poirel L, Jayol A, Nordmann P. 2017. Polymyxins: antibacterial activity, susceptibility testing, and resistance mechanisms encoded by plasmids or chromosomes. Clinical microbiology reviews 30(2), 557-596.

Poole K. 2000. Efflux-mediated resistance to fluoroquinolones in gram-negative bacteria. Antimicrobial agents and chemotherapy 44(9), 2233-2241.

Poole K. 2000. Multidrug efflux pumps and antimicrobial resistance in Pseudomonas aeruginosa and related organisms. Journal of molecular microbiology and biotechnology 3(2), 255-264.

Poole K. 2002. Outer membranes and efflux: the path to multidrug resistance in Gram-negative bacteria. Current pharmaceutical biotechnology, 3(2), 77-98.

Powell M, Livermore DM. 1988. Mechanisms of chloramphenicol resistance in Haemophilus influenzae in the United Kingdom. Journal of Medical Microbiology 27(2), 89-93. https://doi.org/10.1099/00222615-27-2-89

Procópio REdL, Silva IRd, Martins MK, Azevedo JLd, Araújo JMd. 2012. Antibiotics produced by Streptomyces. Brazilian Journal of Infectious Diseases 16(5), 466-471.

Projan SJ. 2000. Preclinical pharmacology of GAR‐936, a novel glycylcycline antibacterial agent. Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy 20(9P2), 219S-223 S.

Quesada A, Porrero MC, Téllez S, Palomo G, García M, Domínguez L. 2015. Polymorphism of genes encoding PmrAB in colistin-resistant strains of Escherichia coli and Salmonella enterica isolated from poultry and swine. Journal of Antimicrobial Chemotherapy 70(1), 71-74.

Rådström P, Fermér C, Kristiansen BE, Jenkins A, Sköld O, Swedberg G. 1992. Transformational exchanges in the dihydropteroate synthase gene of Neisseria meningitidis: a novel mechanism for acquisition of sulfonamide resistance. Journal of bacteriology 174(20), 6386-6393 https://doi.org/0.1128/jb.174.20.6386-6393.1992

Ramirez MS, Tolmasky ME. 2010. Aminoglycoside modifying enzymes. Drug resistance updates 13(6), 151-171.

Rappuoli, R, Mandl CW, Black S,  De Gregorio E. 2011. Vaccines for the twenty-first century society. Nature reviews immunology 11(12), 865-872.

Razavi M, Kristiansson E, Flach CF, Larsson DGJ, LaPara TM. 2020. The Association between Insertion Sequences and Antibiotic Resistance Genes. mSphere 5(5), e00418-00420. https://doi.org/10.1128/mSphere.00418-20

Razavi M, Marathe NP, Gillings MR, Flach CF, Kristiansso E, Joakim Larsson DG. 2017. Discovery of the fourth mobile sulfonamide resistance gene. Microbiome 5(1), 160. https://doi.org/10.1186/s40168-017-0379-y

Reinthaler FF, Posch J, Feierl G, Wüst G, Haas D, Ruckenbauer G, Marth E. 2003. Antibiotic resistance of E. coli in sewage and sludge. Water Research 37(8), 1685-1690. https://doi.org/10.1016/S0043-1354(02)00569-9

Rinke C, Schwientek P, Sczyrba A, Ivanova NN, Anderson IJ, ChengJF, Woyke T. 2013. Insights into the phylogeny and coding potential of microbial dark matter. Nature 499(7459), 431-437. https://doi.org/10.1038/nature12352

Ristuccia AM, Cunha BA. 1985. An overview of amikacin. Therapeutic drug monitoring, 7(1), 12-25.

Roberts MC, Swenson C.D, Owens LM, Smith AL. 1980. Characterization of chloramphenicol-resistant Haemophilus influenzae. Antimicrobial Agents and Chemotherapy 18(4), 610-615. https://doi.org/10.1128/AAC.18.4.610

Robicsek A, Strahilevitz J, Jacoby GA, Macielag M, Abbanat D, Hye Park C, Hooper DC. 2006. Fluoroquinolone-modifying enzyme: a new adaptation of a common aminoglycoside acetyltransferase. Nature medicine 12(1), 83-88.

Rodríguez-Martínez JM, López L, García I, Pascual A. 2006. Characterization of a clinical isolate of Haemophilus influenzae with a high level of fluoroquinolone resistance. Journal of Antimicrobial Chemotherapy 57(3), 577-578. https://doi.org/10.1093/jac/dki488

Rolinson G. 1979. 6-APA and the development of the β-lactam antibiotics. Journal of Antimicrobial Chemotherapy 5(1), 7-14.

Rolinson G. 1979. 6-APA and the development of the β-lactam antibiotics. Journal of Antimicrobial Chemotherapy 5(1), 7-14.

Rolinson G, Stevens S, Batchelor F, Wood JC, Chain E. 1960. Bacteriological studies on a new penicillin-BRL. 1241. Lancet 564-567.

Römling U, Wingender J, Müller H, Tümmler B. 1994. A major Pseudomonas aeruginosa clone common to patients and aquatic habitats. Applied and environmental microbiology 60(6), 1734-1738. https://doi.org/10.1128/aem.60.6.1734-1738.1994

Ronald A, Jagdis F, Harding G, Hoban S, Muir P, Gurwith M. 1977. Amoxicillin therapy of acute urinary infections in adults. Antimicrobial Agents and Chemotherapy 11(5), 780-784.

Rosenblum R, Khan E, Gonzalez G, Hasan R, Schneiders T. 2011. Genetic regulation of the ramA locus and its expression in clinical isolates of Klebsiella pneumoniae. International journal of antimicrobial agents 38(1), 39-45.

Roulston KJ, Bharucha T, Turton JF, Hopkins KL, Mack DJF. 2018. A case of NDM-carbapenemase-producing hypervirulent Klebsiella pneumoniae sequence type 23 from the UK. JMM case reports 5(9), e005130-e005130. https://doi.org/10.1099/jmmcr.0.005130

Roychoudhury S, Catrenich C E, McIntosh EJ, McKeever HD, Makin KM, Koenigs PM, Ledoussal B. 2001. Quinolone resistance in staphylococci: activities of new nonfluorinated quinolones against molecular targets in whole cells and clinical isolates. Antimicrobial agents and chemotherapy 45(4), 1115-1120.

Ryan B, Ho HT, Wu P, Frosco MB, Dougherty T, Barrett JF. 2000. 40th Interscience Conference on antimicrobial agents and chemotherapy (ICAAC). Expert Opinion on Investigational Drugs 9(12), 2945-2972.

Rybak M J, Hershberger E, Moldovan T, Grucz RG. 2000. In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against staphylococci and enterococci, including vancomycin-intermediate and-resistant strains. Antimicrobial agents and chemotherapy 44(4), 1062-1066.

Sáez-NietoJA, Lujan R, Berrón S, Campos J, Viñas M, Fusté C, Martinez-Suarez JV. 1992. Epidemiology and molecular basis of penicillin-resistant Neisseria meningitidis in Spain: a 5-year history (1985–1989). Clinical infectious diseases 14(2), 394-402.

Samuelsen O B, Torsvik V,  Ervik A. 1992. Long-range changes in oxytetracycline concentration and bacterial resistance towards oxytetracycline in a fish farm sediment after medication. Science of the total environment 114, 25-36. https://doi.org/10.1016/0048-9697(92)90411-K

Sánchez L, Leranoz S, Puig M, Lorén JG, Nikaido H, Viñas M. 1997a. Molecular basis of antimicrobial resistance in non-typable Haemophilus influenzae. Microbiologia (Madrid, Spain) 13(3), 309-314.

Sánchez L, Pan W, Viñas M, Nikaido H. 1997b. The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump. Journal of bacteriology 179(21), 6855-6857. https://doi.org/10.1128/jb.179.21.6855-6857.1997

Sanders Jr WE, Sanders CC. 1996. Piperacillin/tazobactam: a critical review of the evolving clinical literature. Clinical Infectious Diseases 22(1), 107-123.

Saravolatz LD, Eliopoulos GM. 2003. Quinupristin-dalfopristin and linezolid: evidence and opinion. Clinical infectious diseases 36(4), 473-481.

Sauvage E, Terrak M. 2016. Glycosyltransferases and transpeptidases/penicillin-binding proteins: valuable targets for new antibacterials. Antibiotics, 5(1), 12.

Schaad UB, Suter S, Gianella-Borradori A, Pfenninger J, Auckenthaler R, Bernath O, Wedgwood J. 1990. A Comparison of Ceftriaxone and Cefuroxime for the Treatment of Bacterial Meningitis in Children. New England Journal of Medicine 322(3), 141-147. https://doi.org/10.1056/nejm199001183220301

Schlünzen F, Zarivach R, Harms J, Bashan, A, Tocilj A, Albrecht R, Franceschi F. 2001. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413(6858), 814-821.

Schlünzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Franceschi F. 2001. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413(6858), 814-821.

Schulz F, Eloe-Fadrosh EA, Bowers RM, Jarett J, Nielsen T, Ivanova NN, Woyke T. 2017. Towards a balanced view of the bacterial tree of life. Microbiome 5(1), 140. https://doi.org/10.1186/s40168-017-0360-9

Schwartz T, Kohnen W, Jansen B, Obst U. 2003. Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. FEMS Microbiology Ecology 43(3), 325-335. https://doi.org/10.1111/j.1574-6941.2003.tb01073.x

Schwartz T, Kohnen W, Jansen B, Obst U. 2003. Detection of antibiotic-resistant bacteria and their resistance genes in wastewater, surface water, and drinking water biofilms. FEMS Microbiology Ecology 43(3), 325-335. https://doi.org/10.1111/j.1574-6941.2003.tb01073.x

Schwarz S, Johnson AP. 2016. Transferable resistance to colistin: a new but old threat. Journal of Antimicrobial Chemotherapy 71(8), 2066-2070.

Schwarz S, Kehrenberg C, Doublet B, Cloeckaert A. 2004. Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS microbiology reviews 28(5), 519-542.

Scornec H, Bellanger X, Guilloteau H, Groshenry G,  Merlin C. 2017. Inducibility of Tn916 conjugative transfer in Enterococcus faecalis by subinhibitory concentrations of ribosome-targeting antibiotics. Journal of Antimicrobial Chemotherapy 72(10), 2722-2728. https://doi.org/10.1093/jac/dkx202

Sette A, Rappuoli R. 2010. Reverse vaccinology: developing vaccines in the era of genomics. Immunity 33(4), 530-541.

Shaikh S, Fatima J, Shakil S, Rizvi SMD, Kamal MA. 2015. Antibiotic resistance and extended spectrum beta-lactamases: Types, epidemiology and treatment. Saudi Journal of Biological Sciences, 22(1), 90-101. https://doi.org/10.1016/j.sjbs.2014.08.002

Shin S W, Shin MK, Jung M, Belaynehe KM, Yoo HS. 2015. Prevalence of antimicrobial resistance and transfer of tetracycline resistance genes in Escherichia coli isolates from beef cattle. Applied and environmental microbiology 81(16), 5560-5566.

Shin SY, Bae IK, Kim J, Jeong S H, Yong D, Kim JM,  Lee K. 2012. Resistance to carbapenems in sequence type 11 Klebsiella pneumoniae is related to DHA-1 and loss of OmpK35 and/or OmpK36. Journal of medical microbiology 61(2), 239-245.

Shintani M, Nour E, Elsayed T, Blau K, Wall I,  Jechalke S, Smalla K. 2020. Plant Species-Dependent Increased Abundance and Diversity of IncP-1 Plasmids in the Rhizosphere: New Insights Into Their Role and Ecology. Frontiers in microbiology 11. https://doi.org/10.3389/fmicb.2020.590776

Shrestha LB. 2005. Life expectancy in the United States.

Shvartzman P, Tabenkin H, Rosentzwaig A, Dolginov F. 1993. Treatment of streptococcal pharyngitis with amoxycillin once a day. British Medical Journal 306(6886), 1170-1172.

Silver LL. 2017. Fosfomycin: mechanism and resistance. Cold Spring Harbor perspectives in medicine 7(2), a025262.

Smith A M, Klugman KP. 1998. Alterations in PBP 1A Essential for High-Level Penicillin Resistance in <i>Streptococcus pneumoniae</i>. Antimicrobial agents and chemotherapy 42(6), 1329-1333. https://doi.org/10.1128/AAC.42.6.1329

Sum PE, Petersen P. 1999. Synthesis and structure-activity relationship of novel glycylcycline derivatives leading to the discovery of GAR-936. Bioorganic & medicinal chemistry letters 9(10), 1459-1462.

Sum PE, Lee VJ, Testa RT, Hlavka JJ, Ellestad GA, Bloom JD, Tally FP. 1994. Glycylcyclines. 1. A new generation of potent antibacterial agents through modification of 9-aminotetracyclines. Journal of medicinal chemistry 37(1), 184-188.

Surgers L, Boyd A, Girard PM, Arlet G, Decré D. 2016. ESBL-producing strain of hypervirulent Klebsiella pneumoniae K2, France. Emerging infectious diseases 22(9), 1687.

Swaney SM, Aoki H, Ganoza MC, Shinabarger DL. 1998. The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria. Antimicrobial agents and chemotherapy 42(12), 3251-3255.

Swartz MN. 2004. Bacterial meningitis—a view of the past 90 years. New England Journal of Medicine, 351(18), 1826-1828.

Swick MC, Morgan-Linnell SK, Carlson K M, Zechiedrich L. 2011. Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistance. Antimicrobial agents and chemotherapy 55(2), 921-924.

Taber HW, Mueller JP, Miller PF, Arrow A. 1987. Bacterial uptake of aminoglycoside antibiotics. Microbiological reviews 51(4), 439-457.

Tally F, Ellestad G, Testa R. 1995. Glycylcyclines: a new generation of tetracyclines. Journal of Antimicrobial Chemotherapy 35(4), 449-452.

Tartaglione TA, Polk RE. 1985. Review of the New Second-Generation Cephalosporins: Cefonicid, Ceforanide, and Cefuroxime. Drug Intelligence & Clinical Pharmacy 19(3), 188-198. https://doi.org/10.1177/106002808501900304

Telenti A, Imboden P, Marches F, Matter L, Schopfer K, Bodmer T, Cole S. 1993. Detection of rifampicin-resistance mutations in Mycobacterium tuberculosis. The Lancet 341(8846), 647-651.

Thorne GM, Alder J. 2002. Daptomycin: a novel lipopeptide antibiotic. Clinical Microbiology Newsletter 24(5), 33-40.

Tipper DJ,  Strominger JL. 1965. Mechanism of action of penicillins: a proposal based on their structural similarity to acyl-D-alanyl-D-alanine. Proceedings of the National Academy of Sciences of the United States of America 54(4), 1133.

Tolls J. 2001. Sorption of Veterinary Pharmaceuticals in Soils:  A Review. Environmental Science & Technology 35(17), 3397-3406. https://doi.org/10.1021/es0003021

Top E, Smet ID, Verstraete W, Dijkmans R, Mergeay M. 1994. Exogenous Isolation of Mobilizing Plasmids from Polluted Soils and Sludges. Applied and environmental microbiology 60(3), 831-839. https://doi.org/10.1128/aem.60.3.831-839.1994

Tran JH, Jacoby GA, Hooper DC. 2005. Interaction of the plasmid-encoded quinolone resistance protein Qnr with Escherichia coli DNA gyrase. Antimicrobial agents and chemotherapy, 49(1), 118-125.

Ullah H, Ali S. 2017. Classification of anti-bacterial agents and their functions. Antibacterial agents 10, 1-10.

Vaara M. 1992. Agents that increase the permeability of the outer membrane. Microbiological reviews 56(3), 395-411.

van Heijenoort J, Gutmann L. 2000. Correlation between the structure of the bacterial peptidoglycan monomer unit, the specificity of transpeptidation, and susceptibility to β-lactams. Proceedings of the national academy of sciences 97(10), 5028-5030.

Vandecraen J, Chandler M, Aertsen A, Van Houdt R. 2017. The impact of insertion sequences on bacterial genome plasticity and adaptability. Critical Reviews in Microbiology 43(6), 709-730. https://doi.org/10.1080/1040841X.2017.1303661

Vollmer W, Bertsche U. 2008. Murein (peptidoglycan) structure, architecture and biosynthesis in Escherichia coli. Biochimica et Biophysica Acta (BBA)-Biomembranes 1778(9), 1714-1734.

Waglechner N, Wright GD. 2017. Antibiotic resistance: it’s bad, but why isn’t it worse? BMC Biology 15(1), 84. https://doi.org/10.1186/s12915-017-0423-1

Wang X, Chen H, Zhang Y, Wang Q, Zhao C, Li H, Li S. 2015. Genetic characterisation of clinical Klebsiella pneumoniae isolates with reduced susceptibility to tigecycline: role of the global regulator RamA and its local repressor RamR. International journal of antimicrobial agents 45(6), 635-640.

Wang X, Zhu Y, Hua X, Chen F, Wang C, Zhang Y, Zhang W. 2018. F14: A-: B-and IncX4 Inc group cfr-positive plasmids circulating in Escherichia coli of animal origin in Northeast China. Veterinary microbiology 217, 53-57.

Wang XM, Dong Z, Schwarz, S, Zhu Y, Hua X, Zhang Y, Zhang WJ. 2017. Plasmids of diverse Inc groups disseminate the fosfomycin resistance gene fosA3 among Escherichia coli isolates from pigs, chickens, and dairy cows in Northeast China. Antimicrobial agents and chemotherapy 61(9), e00859-00817.

Waters B, Davies J. 1997. Amino acid variation in the GyrA subunit of bacteria potentially associated with natural resistance to fluoroquinolone antibiotics. Antimicrobial agents and chemotherapy 41(12), 2766-2769. https://doi.org/10.1128/AAC.41.12.2766

Wei Dd, Wan LG, Deng Q, Liu Y. 2016. Emergence of KPC-producing Klebsiella pneumoniae hypervirulent clone of capsular serotype K1 that belongs to sequence type 11 in Mainland China. Diagnostic Microbiology and Infectious Disease, 85(2), 192-194. https://doi.org/10.1016/j.diagmicrobio.2015.03.012

Weston N, Sharma P, Ricci V, Piddock LJ. 2018. Regulation of the AcrAB-TolC efflux pump in Enterobacteriaceae. Research in microbiology, 169(7-8), 425-431.

Whitney CG, Farley MM, Hadler J, Harrison LH, Lexau C, Reingold A, Zell ER. 2000. Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. New England Journal of Medicine 343(26), 1917-1924.

WHO G. 2018. Antibiotic resistance: World Health Organization Geneva.

WHO. 2014. Antimicrobial resistance: global report on surveillance: World Health Organization.

Widdowson CA, Klugman KP. 1999. Molecular mechanisms of resistance to commonly used non-betalactam drugs in Streptococcus pneumoniae. Seminars in respiratory infections 14(3), 255-268.

Wiener P, Egan S, Wellington EMH. 1998. Evidence for transfer of antibiotic-resistance genes in soil populations of streptomycetes. Molecular Ecology 7(9), 1205-1216. https://doi.org/10.1046/j.1365-294x.1998.00450.x

Wilson DN. 2014. Ribosome-targeting antibiotics and mechanisms of bacterial resistance. Nature Reviews Microbiology 12(1), 35-48.

Winterscheid KK, Whittington W, Roberts MC, Schwebke JR, Holmes KK. 1994. Decreased susceptibility to penicillin G and Tet M plasmids in genital and anorectal isolates of Neisseria meningitidis. Antimicrobial agents and chemotherapy 38(7), 1661-1663.

Witte W. 1998. Medical Consequences of Antibiotic Use in Agriculture. Science 279(5353), 996-997. https://doi.org/10.1126/science.279.5353.996

Woolhouse ME, Ward MJ. 2013. Sources of antimicrobial resistance. Science 341(6153), 1460-1461.

Workowski KA, Levine WC, Wasserheit JN. 2002. US Centers for Disease Control and Prevention guidelines for the treatment of sexually transmitted diseases: an opportunity to unify clinical and public health practice. Annals of internal medicine 137(4), 255-262.

Worthington RJ, Melander C. 2013. Overcoming resistance to β-lactam antibiotics. The Journal of organic chemistry 78(9), 4207-4213.

Xie Y, Tian L, Li G, Qu H, Sun J, Liang W, Liu J. 2018. Emergence of the third-generation cephalosporin-resistant hypervirulent Klebsiella pneumoniae due to the acquisition of a self-transferable bla DHA-1-carrying plasmid by an ST23 strain. Virulence 9(1), 838-844.

Xiong L, Shah S, Mauvais P,  Mankin AS. 1999. A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre. Molecular microbiology, 31(2), 633-639.

Xiong L, Shah S, Mauvais P,  Mankin AS. 1999. A ketolide resistance mutation in domain II of 23S rRNA reveals the proximity of hairpin 35 to the peptidyl transferase centre. Molecular microbiology, 31(2), 633-639.

Xu M, Li A, Kong H, Zhang W, Chen H, Fu Y,  Fu Y. 2018. Endogenous endophthalmitis caused by a multidrug-resistant hypervirulent Klebsiella pneumoniae strain belonging to a novel single locus variant of ST23: first case report in China. BMC infectious diseases 18(1), 1-6.

Yague G, Morris JE, Pan XS, Gould KA,  Fisher LM. 2002. Cleavable-complex formation by wild-type and quinolone-resistant Streptococcus pneumoniae type II topoisomerases mediated by gemifloxacin and other fluoroquinolones. Antimicrobial agents and chemotherapy 46(2), 413-419.

Yamada H, Hisada H, Mitsuyama J, Takahata M, Todo Y, Minami S, Narita H. 2000. BMS-284756 (T-3811ME), a des-fluoro (6)-quinolone. Selectivity between bacterial and human type II DNA topoisomerases, abstr. C-753. Paper presented at the Proceedings of the 37th Interscience Conference on Antimicrobial Agents and Chemotherapy. American Society for Microbiology, Washington, DC.

Yoshizawa H, Itani H, Ishikura K, Irie T, Yokoo K, Kubota T, Nishitani Y. 2002. S-3578, a new broad spectrum parenteral cephalosporin exhibiting potent activity against both methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa. Synthesis and structure-activity relationships. J Antibiot (Tokyo) 55(11), 975-992. https://doi.org/10.7164/antibiotics.55.975

Yu WL, Lee MF, Chen CC, Tang HJ, Ho CH,  Chuang YC. 2017. Impacts of hypervirulence determinants on clinical features and outcomes of bacteremia caused by extended-spectrum β-lactamase-producing Klebsiella pneumoniae. Microbial Drug Resistance 23(3), 376-383.

Zaffiri L, Gardner J, Toledo-Pereyra LH. 2012. History of antibiotics. From salvarsan to cephalosporins. Journal of Investigative Surgery, 25(2), 67-77.

Zapun A, Contreras-Martel C, Vernet T. 2008. Penicillin-binding proteins and β-lactam resistance. FEMS microbiology reviews 32(2), 361-385.

Zhan L, Wang S, Guo Y, Jin Y, Duan J, Hao Z, Yu F. 2017. Outbreak by Hypermucoviscous Klebsiella pneumoniae ST11 Isolates with Carbapenem Resistance in a Tertiary Hospital in China. Frontiers in Cellular and Infection Microbiology 7. https://doi.org/10.3389/fcimb.2017.00182

Zhanel GG, Sniezek G, Schweizer F, Zelenitsky S, LagacéWiens PRS, Rubinstein E, Karlowsky JA. 2009. Ceftaroline. Drugs 69(7), 809-831.https://doi.org/10.2165/00003495-200969070-00003

Zhanel GG, Wiebe R, Dilay L, Thomson K, Rubinstein E, Hoban DJ, Karlowsky JA. 2007. Comparative review of the carbapenems. Drugs 67(7), 1027-1052.

Zhang R, Lin D, Chan EWc, GuD, Chen GX, Chen S. 2016. Emergence of Carbapenem-Resistant Serotype K1 Hypervirulent Klebsiella pneumoniae Strains in China. Antimicrobial agents and chemotherapy 60(1), 709-711. https://doi.org/10.1128/AAC.02173-15

Zhang Y, Zeng J, Liu W, Zhao F, Hu Z, Zhao C, Wang H. 2015. Emergence of a hypervirulent carbapenem-resistant Klebsiella pneumoniae isolate from clinical infections in China. Journal of Infection, 71(5), 553-560. https://doi.org/10.1016/j.jinf.2015.07.010