Epidemiological studies of antibiotic resistance in pathogens isolated from blood cultures of people from Cuddalore District

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Research Paper 17/03/2023
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Epidemiological studies of antibiotic resistance in pathogens isolated from blood cultures of people from Cuddalore District

C. Uma Maheswari, V. Arul Balaji, J. Vigneshwari,G. Vinitha, M. Shenbagam
Int. J. Biosci.22( 3), 51-55, March 2023.
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Infections due to multidrug-resistant (MDR) microorganisms have triggered antimicrobial resistance among the antibiotics pattern. Antimicrobial resistance (AMR) in pathogens isolated from blood cultures is currently one of the most concerning issues in medicine. This study was to investigate the AMR distribution of the blood-borne pathogens isolated over two years in the Cuddalore region. A surveying laboratory-confirmed bloodstream infection (BSIs) was done and data from various major diagnostic laboratories were used. During the study period, 390 positive BSIs were collected. The prevalence of gram-positive bacteria (51%) and gram-negative bacteria (49%). The most common pathogens were gram-positive isolates Staphylococcus haemolyticus (38%) and Staphylococcus home. hominis (31%) and gram-negative isolates Enterobacter cloacae complex (13%), Acinetobacter haemolyticus and Klebsiella pneumonia (18%). The gram-positive Staphylococcus haemolyticus and Staphylococcus hom. hominis showed the highest resistance and sensitivity antibiotics pattern. Tigecycline was a highly sensitive antibiotic against all gram-positive isolates. Citro. Koseri showed sensitivity among the gram-negative antibiotic pattern. High resistance rates to both frontline antibiotics were observed for all gram-positive organisms isolated from blood cultures.


Alagesan M, Gopalakrishnan R, Panchatcharam SN, Dorairajan S, Mandayam Ananth T, Venkatasubramanian R. 2015. A decade of change in susceptibility patterns of Gram-negative blood culture isolates: A single center study, Germs 5(3), 65-77. https://doi.org/10.11599%2Fgerms.2015.1073

Laxminarayan R, Chaudhury RR. 2016. Antibiotic resistance in India: Drivers and opportunities for action, PLoS Medicine 13(3). https://doi.org/10.1371/journal.pmed.1001974

Mogasale VV, Saldanha P, Pai V. 2021. A descriptive analysis of antimicrobial resistance patterns of WHO priority pathogens isolated in children from a tertiary care hospital in India. Sci. Rep. 11, 5116. https://doi.org/10.1038/s41598-021-84293-8

Prestinaci F, Pezzotti P, Pantosti A. 2015. Antimicrobial resistance: A global multifaceted phenomenon, Pathogens and Global Health. 109(7), 309-318. https://doi.org/10.1179/2047773215Y.0030

Revelas A. 2012. Healthcare – associated infections: a public health problem. Niger, Medical Journal 53(2), 59. https://doi.org/10.4103%2F0300-1652.103543

Saeidinia A, Keihanian F, Delavar SF, Keihanian F, Ranjbar A, Karkan MF. 2016. Lack of antibacterial activity of Ruta graveolens extracts against Enterococcus fecalis, Pakistan Journal of Pharma Science 29(4), 1371-1374.

Saeidinia A, Tavakoli I, Naghipour MR. 2016. Prevalence of Strongyloides stercoralis and other intestinal parasites among institutionalized mentally disabled individuals in Rasht, Northern Iran, Iranian Journal of Parasitology 11(4), 527-533.

Saeidynia F, Keihanian F, Saeidynia A. 2014.Antibiotic resistance in blood culture samples from patients referred to Razi laboratory of Rasht. Advances in Infectious Diseases 4(03), 165-172. DOI:10.4236/aid.2014.43023

Sumanth Gandra, Nestor Mojica, Eili Y. 2014. Klein, Ashvin Ashok, Vidya Nerurkar, Mamta Kumari, Uma Ramesh, Sunanda Dey, Viral Vadwai, Bibhu R. Das, Ramanan Laxminarayan. Trends in antibiotic resistance among major bacterial pathogens isolated from blood cultures tested at a large private laboratory network in India, 2008. International Journal of Infectious Diseases 50, 75-82. https://doi.org/10.1016/j.ijid.2016.08.002

Walia K. 2019. Establishing antimicrobial resistance surveillance & research network in India, Journey so far. The Indian Journal of Medicine, Res 149(2), 164-179. https://doi.org/10.4103%2Fijmr.IJMR_22

Zhang X, Gu B, Mei Y, Wen Y, Xia W. 2015.Increasing resistance rate to carbapenem among blood culture isolates of Klebsiella pneumoniae, Acinetobacter baumannii and Pseudomonas aeruginosa in a university affiliated hospital in China, 2004-2011. The Journal of Antibiotics 68(2), 115-120.