Evaluation of potential cytotoxicity of the extracts from soft corals collected from the Philippine Sea of Mindanao: Sarcophyton glaucum, Lobophytum pauciflorum, Sinularia flexibilis and Lobophytum crassum
Paper Details
Evaluation of potential cytotoxicity of the extracts from soft corals collected from the Philippine Sea of Mindanao: Sarcophyton glaucum, Lobophytum pauciflorum, Sinularia flexibilis and Lobophytum crassum
Abstract
Soft corals have been shown to possess a rich variety of marine secondary metabolites and are considered an extremely diverse group of marine organisms. This study explored the potential cytotoxicity of soft corals collected from the Philippine Sea of Mindanao namely Sarcophyton glaucum (Sg), Lobophytum pauciflorum (Lp), Sinularia flexibilis (Sf) and Lobophytum crassum (Lc). Polar (P) and nonpolar (NP) extracts of the soft corals were prepared by sequential extraction of the freezed-dried samples with 50:50 ethanol-water and 50:50 ethylacetate-methanol, respectively. The resulting extracts were tested for their cytotoxic activity using the brine shrimp Artemia salina lethality test (BSLT). Results show that amongst the five soft corals, The polar extract of S. glaucum (SgP) exhibited interesting bioactivity with acute and chronic LC50 values of 324.00 ppm and 35.50 ppm, respectively. The results indicate that the soft coral S. glaucum may contain potential antitumor or pesticidal components and is thus worthy of further investigation.
Benayahu Y, van Ofwegen LP. 2011. New Species of Octocorals (Coelenterata: Anthozoa) from the Penghu Archipelago, Taiwan. Zoological Studies 50(3), 350-362. Retrieved from http://zoolstud.sinica.edu.tw/Journals/50.3/350.pdf
Coll JC. 1992. The chemistry and chemical ecology of octocorals (Coelenterata, Anthozoa, Octocorallia). Chemical Reviews 92(4), 613-631. http://dx.doi.org/10.1021/cr00012a006
Costa IM, Pimentel AB, Pizzolatti MG. 2002. An Application of the Brine Shrimp Bioassay for General Screening of Brazilian Medicinal Plants. Acta Farmacéutica Bonaerense 21(3), 175-178.
Gallimore W. 2017. Marine Metabolites: Oceans of Opportunity. http://dx.doi.org/10.1016/B978-0-12-802104-0.00018-4.
Liang LF, Guo YW. 2013. Terpenes from the Soft Corals of the Genus Sarcophyton: Chemistry and Biological Activities. Chemistry & Biodiversity. 10(12), 2161-2196. http://dx.doi.org/10.1002/cbdv.201200122
Meyer BN, Ferrighi NR, Putnam JE, Jacobsen LB, Nichols DE, Mclaughlin JL. 1982. Brine shrimp: A convenient general bioassay for active plant constituents. Planta Medica. 45, 31-34.
Momtaz ZSK. 2016. Soft corals Sarcophyton glaucum as insecticide against Rice weevils Sitophilus oryzae (Coleoptera: curculionidae).IOSR Journal of Environmental Science, Toxicology and Food Technology (IOSR-JESTFT) 10(11), 10-14. http://dx.doi.org/10.9790/2402-1011031014
Ocean Defender: Philippine Seas. 2013. Retrieved from: www.greenpeace.org.ph/oceans
Peng BR, Lu MC, El-Shazly M, Wu SL, Lai KH, Su JH. 2018. Aquaculture Soft Coral Lobophytum crassum as a Producer of Anti-Proliferative Cembranoids. Marine Drugs 16(1), pii: E15. http://dx.doi.org/10.3390/md16010015
Sinha C. 2012, November. Coral reefs in the Philippines: ‘Rainforest of the Sea’. Manila Times. Retrieved from: https://www.pressreader.com
Turk T, Kem WR. 2009. The phylum Cnidaria and investigations of its toxins and venoms until 1990, Toxicon 54(8), 1031-1037. http://dx.doi.org/10.1016/j.toxicon.2009.06.031
Ullah MO, Haque M, Urmi KF, Zulfiker AHM, Anita ES, Begum M. 2013. Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh. Asian Pacific Journal of Tropical Biomedicine 3(1), 1-7. http://dx.doi.org/10.1016/S2221-1691(13)60015-5
Harmie N. Luyao, Ephrime B. Metillo, Mylene M. Uy, 2019. Evaluation of potential cytotoxicity of the extracts from soft corals collected from the Philippine Sea of Mindanao: Sarcophyton glaucum, Lobophytum pauciflorum, Sinularia flexibilis and Lobophytum crassum. Int. J. Biosci., 14(2), 438-444.
Copyright © 2019 by the Authors. This article is an open access article and distributed under the terms and conditions of the Creative Commons Attribution 4.0 (CC BY 4.0) license.