Exploring pharmacologically significant bioactive compounds of Psoralea corylifolia L.- A review
Paper Details
Exploring pharmacologically significant bioactive compounds of Psoralea corylifolia L.- A review
Abstract
Psoralea corylifolia, a Chinese medicinal plant belonging to the Fabaceae family, has long been esteemed in various traditional medicine systems. Recent scrutiny into its phytochemistry and pharmacology unveils a treasure trove of secondary metabolites, totaling 63, delineated into six structural categories: flavonoids, meroterpenes, furanocoumarins, coumestans, steroids, and phenolic compounds. Foremost among these compounds is bakuchiol, a meroterpene gaining traction in the cosmetic industry for its noted anti-aging and anti-acne properties. Furanocoumarins like psoralen and isopsoralen exhibit efficacy in treating psoriasis and vitiligo by inducing skin pigmentation. Moreover, the spectrum of bioactivities demonstrated by other secondary metabolites from P. corylifolia is vast, encompassing antibacterial, anti-inflammatory, antioxidant, antidiabetic, anti-obesity, hepatoprotective, estrogenic, osteogenic, and anticancer effects. Looking ahead, the study underscores both challenges and opportunities for advancing research and development in this domain. Key focal points include optimizing extraction and isolation techniques, standardizing and controlling the quality of plant materials and extracts, elucidating mechanisms of action and molecular targets, and assessing the safety and toxicity profiles of secondary metabolites. In conclusion, P. corylifolia emerges as a botanical gem, poised to unlock novel pharmaceutical and cosmetic avenues. Its multifaceted pharmacological potential underscores its significance in contemporary medicine and warrants further exploration and harnessing of its bioactive constituents.
Ali H, Dixit S, Alam P. 2018. Psoralea corylifolia L. (Buguchi) – folklore to modern evidence: review. Fitoterapia 124, 92-96. DOI: 10.1016/j.fitote.2017.11.016.
Dong X, Zhang Z, He S, Wang X. 2020. Progress on the Pharmacological Research of Psoralea corylifolia Linn.: A Review. Frontiers in Pharmacology 11, 457. DOI: 10.3389/fphar.2020.00457.
Gupta M, Mahajan S. 2020. Review on pharmacological and pharmacognostical properties of Psoralea corylifolia. World Journal of Pharmacy and Pharmaceutical sciences 9(8), 235-252.
Khushboo KS, Srivastava S. 2019. A comprehensive review on pharmacological activities of Psoralea corylifolia L. (Buguchi). International Journal of Green Pharmacy 13(2), 143-150. DOI: 10.22377/ijgp.v13i02.2685.
Kumar N, Singh B. 2020. A comprehensive review on phytochemistry and pharmacological activities of Psoralea corylifolia L. Natural Product Research, 1-14. DOI: 10.1080/14786419.2020.1776793
Li S, Zhang B, Jiang D, Wei Y, Zhang N. 2019. Phytochemistry, pharmacology, quality control, and future research of Psoralea corylifolia L. Chinese Herbal Medicines 11(3), 227-237. DOI: 10.1016/j.chmed.2019.05.002.
Pandey R, Gupta S. 2016 Psoralea corylifolia (Babchi): An overview. Int J Pharm Sci Rev Res. 38(1), 51-58.
Pandey R, Mishra, A. 2019. Pharmacological potential of Psoralea corylifolia L.- A review. Journal of Applied Pharmaceutical Science 9(4), 127-136. DOI: 10.7324/JAPS.2019.90417
Patel S, Sharma V. 2021. Psoralea corylifolia Linn: Ethnobotanical, phytochemical and pharmacological review. Journal of Applied Pharmaceutical Science, 11(4), 157-166. DOI: 10.7324/JAPS.2021.11422.
Sharma P, Rani R, Pal S, Malhotra S. 2020. Psoralea corylifolia Linn. – A comprehensive review of its ethnopharmacology, phytochemistry, and pharmacological properties. Journal of Ethnopharmacology 247, 112255. DOI: 10.1016/j.jep.2019.112255
Wang L, Li Y, Guo Y, 2020. Psoralen protects chondrocytes, exhibits anti-inflammatory effects on synoviocytes, and attenuates monosodium iodoacetate-induced osteoarthritis. Int Immunopharmacol 86, 106726.
Wang Y, Zhu L, He J, Huang D. 2021. Phytochemistry, pharmacology, and clinical application of Psoralea corylifolia Linn.: A systematic review. Frontiers in Pharmacology 12, 666459. DOI: 10.3389/fphar.2021.666459
Zhao K, Jiang Y. 2018. Psoralea corylifolia Linn.: A review of its traditional uses, phytochemistry, pharmacology, and toxicology. Biomedicine & Pharmacotherapy 105, 53-70. DOI: 10.1016/j.biopha.2018.05.060
Zhou J, Wu J, Chen X, 2020. Chemical composition and pharmacological activities of Psoralea corylifolia Linn. Phytother Res. 34(9), 2229-2254.
G. Bhagirath, G. Surendra Reddy, M. D. Mustafa (2024), Exploring pharmacologically significant bioactive compounds of Psoralea corylifolia L.- A review; IJBB, V18, N2, April, P11-18
https://innspub.net/exploring-pharmacologically-significant-bioactive-compounds-of-psoralea-corylifolia-l-a-review/
Copyright © 2024
By Authors and International
Network for Natural Sciences
(INNSPUB) https://innspub.net
This article is published under the terms of the
Creative Commons Attribution License 4.0