Exploring the therapeutic efficacy of PLGA-NDP: A comprehensive analysis in OECM-1 oral cancer cells
Paper Details
Exploring the therapeutic efficacy of PLGA-NDP: A comprehensive analysis in OECM-1 oral cancer cells
Abstract
The present study investigates the therapeutic efficacy of PLGA encapsulated nedaplatin (PLGA-NDP) in oral cancer OECM-1 cells. PLGA-NDP exhibited greater release activity, a lower degree of redox reaction, and increased cytotoxicity, as indicated by the results of the MTT assay, Alamar Blue assay, and β-hexosaminidase release activity, than nedaplatin alone. The survival of the cells in the colony formation assay was significantly decreased for cells treated with PLGA-NDP, as observed by its increased cytotoxic effect and ability to prevent cells from growing colonies when compared with nedaplatin alone. The fewer release of MMP-9 in the presence of PLGA-NDP-8ug/mL also suggests that PLGA-NDP can inhibit the degranulation of cells, a process that promotes cancer invasion and metastasis. PLGA-NDP treatment was more effective in a dose-dependent manner, indicating it as a new therapeutic strategy in the treatment of oral cancer. These findings indicate that PLGA-nedaplatin nanoparticles could be effective therapeutic agent. This result suggests that PLGA encapsulated nedaplatin nanoparticles could present an increase effective therapeutic agent than conventional nedaplatin therapy and therefore less side-effects and improved therapeutic efficacy. It needs much further research to be better understood in their limitations and mode of action before they can be considered for clinical use than conventional nedaplatin chemotherapy, possibly leading to decreased side effects and improved therapeutic efficacy.
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Senkuttuvan Ilanchit Chenni, Kathiresan Suresh, Azhamuthu Theerthu, Abulkalam Asath Nihal Ahamed, Ravichandran Pugazhendhi, Rajeswari Vasu, 2025. Exploring the therapeutic efficacy of PLGA-NDP: A comprehensive analysis in OECM-1 oral cancer cells. Int. J. Biosci., 27(1), 73-82.
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