Flavonol glycosides from the leaves of Astragalus microcephalus

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Research Paper 01/07/2012
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Flavonol glycosides from the leaves of Astragalus microcephalus

Fatemeh Fathiazad, Ali Movafeghi, Mohammad karim Khosropanah
Int. J. Biosci. 2(7), 23-28, July 2012.
Copyright Statement: Copyright 2012; The Author(s).
License: CC BY-NC 4.0

Abstract

Four new flavonol glycosides were isolated from the leaves of Astragalus microcephalus. The structures of the new compounds were established as Isorhamnetin-3-O- [β-D-apiofuranosyl (1→3)]-β-D-glucopyranoside (Microcephalin I), Isorhamnetin-3-O– [α-L-rhamnopyranosyl (1→3)]-β-D-glucopyranoside (Microcephalin II), Their strucrures were totally elucidated based on spectroscopic methods, 1D- (1H, 13C, 13C DEPT) and 2D- NMR experiments as well as UV spectra analysis..

Benbassat N, Nikolov S. 1995. Flavonoids from Astragalus onobrychis. Planta Medica 61, 100-102.

Cao G, Sofic E, Prior RL. 1997. Antioxidant and Prooxidant Behavior of Flavonoids: Structure-Activity Relationships. Free Radical Biology and Medicine 22(5), 749-760.

Cook NC, Samman S. 1996. Flavonoids— Chemistry, metabolism, cardioprotective effects, and dietary sources. The Journal of Nutritional Biochemistry 7(2), 66–76.

Cui B, Kinjo J, Nakamura M, Nohara T. 1991. A novel acylated flavonoid glycoside from Astragalus complanatus. Tetrahedron Letters 32(43), 6135– 6138.

Fathiazad F, M.K. Khosropanah MK, MovafeghI A. 2010. Cycloartane-type glycosides from the roots of Astragalus caspicus Bieb. Natural Product Research 24, 1069-1078.

Ghahreman A, Maassoumi AA, Ghahremani-nejad F. 2002. Astragalus tuyehensis (Fabaceae), a new species from Iran. Novon 12, 47-49.

Harborne JB, Williams CA. 2000. Advances in flavonoid research since 1992. Phytochemistry 55(6), 481-504.

Lemańska K, Szymusiak H, Tyrakowska B, Zieliński R, Soffers AEMF, Rietjens IMCM. 2001. The influence of pH on antioxidant properties and the mechanism of antioxidant action of hydroxyflavones. 31(7), 869–881.

Maasoumi AA. 1998. Astragalus in the Old World. Tehran, Research institute of forests and rangelands.

Mabry TJ, Markham KR, Thomas MB. 1970. The Systematic  Identification  of  Flavonoids.  New  York, Springer.

Marichcova LM, Paskov DS. 1984. Astragalus centralpinus: a potential medicinal plant containing valuable bioflavonoids. Groupe Polyphenols Bulletin de Liaison 12, 305-307.

Markham KR, Mabry TJ. 1975. Ultraviolet-visible and proton magnetic resonance spectroscopy of flavonoids. In Harborne JB, Mabry TJ and Mabry H, ed. The Flavonoids. London: Chapman and Hall: 45-77.

Markham KR, Mohan Chari V. 1982. The Flavonoids Advances in Research. London, Chapman and Hall.

Norris FA, Stermitz FR. 1970. 4′-O-Methylquercetin-3-glucoside from Astragalus miser Dougl. var. oblongifolius. Phytochemistry 9, 229.

Ozipek M, Calis I. 2003. Amino acid, flavonoid and neolignan glucosides from Astragalus melanophrurius. Journal of Faculty of pharmacy, Hacettepe University 23, 85-94.

Pistelli L, Giachi I, Elena L, Bertoli A. 2003. Further saponins and Flavonoids from Astragalus verrucosus Moris. Pharmaceutical biology 41, 568-572.

Podlech D, Sytin A. 2002. New species of Astragalus L. (Leguminosae) sect. Hololeuce, Onobrychoidei, Ornithopodium and Synchoreati and a new section Baldaccia. Sendtnera 8, 155-166.

Podlech D, Zarre S. 2003. New species of Astragalus sect. Ammodendron (Fabaceae) with a key for the species of the Flora Iranica area. Willdenowia 33, 314-352.

Podlech M. 2001. Contributions to the knowledge of the genus Astragalus L. (Leguminosae) VII-X. Sendt near 7, 163-201.

Semmar N, Jay M, Farman M, Chemli R. 2005. Chemotaxonomicanalysis of Astragalus caprinus (Fabaceae) based on the flavonicpatterns. Biochemical Systematics and Ecology 33(2), 187–200.

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