Formulation development using different natural and semi synthetic polymers, in vitro evaluation of colon targeted Sulfasalazine tablets for ulcerative colitis

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Research Paper 01/07/2019
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Formulation development using different natural and semi synthetic polymers, in vitro evaluation of colon targeted Sulfasalazine tablets for ulcerative colitis

Yasir Mehmood, Hammad Yousaf, Umer Farooq, Humayun Riaz, Noviara Saleem, Muhammad Billal Hassan, Rana Khalid Mahmood, Abdul RaheemMalik, Muhammad Sameer Ashaq, Abdulmannan Kashif, Tehseen Zahra, Syed Atif Raza
Int. J. Biosci.15( 1), 42-55, July 2019.
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In this present research work, the aim was to develop colonic targeted matrix tablets of Sulfasalazine for colonitis treatment. Matrix tablets of Sulfasalazine were prepared using microsomal enzyme dependent polymers by wet granulation compression method.The colon targeted tablets were prepared using various polymers in combination. All pharmacopeia tests were performed to ensure its specifications. The colon-targeting tablets prepared via wet granulation method. Different polymers used in controlled release formulation for colon. The compatibility was assessed using FT-IR,XRD and DSC studies for pure drug, polymers and their physical mixtures. The physicochemical properties of all the prepared matrix tablets batches were found to be in limits. The drug content percentage in the optimized formulation H was found to be 99.24 ± 0.10%. Formulations H was containing 2.8% of pectin and 5.7% of HPMC K15M and 11.5% Guar gum and release of drug is about 4% in basic medium (6.8pH) for 3 hrs. This was acceptable range for colon targeting drugs in 3 hrs using medium of 6.8pH. The study concluded that that colon targeted tablets can target the colon and extend the release of sulfasalazine in colon for many hours and also ensure enhanced bioavailability.


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