Generation of reactive oxygen species and their impact on the health related parameters: A critical review

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Generation of reactive oxygen species and their impact on the health related parameters: A critical review

Muhammad Usman Khan, Nuareen Aziz Qurashi, Muhammad Saleem Khan, Farhat Jabeen, Ali Umar, Junaid Yaqoob, Muhammad Wajid
Int. J. Biosci.9( 1), 303-323, July 2016.
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Abstract

Reactive oxygen species (ROS) are highly reactive molecules produced during cellular metabolism and due to some environmental factors. These species have ability to induce damage in vital molecules. The body has several antioxidant systems to cope with but imbalance of oxidants and antioxidants creates a condition commonly known as oxidative stress. The excess production of ROS is the main cause of oxidative stress. In last forty years, oxidative stress was considered as major factors for pathological disorders and ageing. In body, ROS have dual role either beneficial or harmful in the biological systems. They either act as beneficial (NO) in the form of signaling or harmful producing the health disorders. Mitochondrion is the major site for ROS production. The other sources include peroxisomes, endoplasmic reticulum, membrane and cytosol. ROS are studying for their pathogenesis of obesity, diabetes, cancer, inflammation, cardiovascular disease, neurodegenerative disorders and aging. In this review, sources, causes and consequences of superoxide radical, singlet oxygen, ozone, hydrogen peroxide, hydroxyl radical, peroxynitrite, peroxyl and alkoyl radicals and reactive nitrogen species are critically analyzed and discussed in details

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Afonso V, Champy R, Mitrovic D, Collin P, Lomri A. 2007. Reactive oxygen species and superoxide dismutases: role in joint diseases. Joint Bone Spine 74(4), 324-329. http://dx.doi.org/10.1016/j.jbspin.2007.02.002

Agarwal A, Banerjee A, Banerjee U. 2011. Xanthine oxidoreductase: a journey from purine metabolism to cardiovascular excitation-contraction coupling. Critical reviews in biotechnology 31(3), 264-280. http://dx.doi.org/10.3109/07388551.2010.527823

Aikens J, Dix T. 1991. Perhydroxyl radical (HOO.) initiated lipid peroxidation. The role of fatty acid hydroperoxides. Journal of Biological Chemistry 266(23), 15091-15098. http://dx.doi.org/10.1006/abbi.1993.1455

Ala A, Walker AP, Ashkan K, Dooley JS, Schilsky ML. 2007. Wilson’s disease. The Lancet 369(9559), 397-408.  http://dx.doi.org/10.1016/s0140-6736(07)60196-2

Alexandrova M, Bochev P, Markova V, Bechev B, Popova M, Danovska M, Simeonova V. 2004. Dynamics of free radical processes in acute ischemic stroke: influence on neurological status and outcome. Journal of Clinical Neuroscience 11(5), 501-506. http://dx.doi.org/10.1016/j.jocn.2003.10.015

Ambrosone CB, Freudenheim JL, Thompson PA, Bowman E, Vena JE, Marshall JR, Graham S, Laughlin R, Nemoto T, Shields PG. 1999. Manganese superoxide dismutase (MnSOD) genetic polymorphisms, dietary antioxidants, and risk of breast cancer. Cancer research 59(3), 602-606.

Ambrus A, Torocsik B, Tretter L, Ozohanics O, Adam-Vizi V. 2011. Stimulation of reactive oxygen species generation by disease-causing mutations of lipoamide dehydrogenase. Human molecular genetics, ddr202. http://dx.doi.org/10.1093/hmg/ddr202

Asghar MS, Quershi NA, Jabeen F, Shakeel M, Khan MS. 2016. Genotoxicity and oxidative stress analysis in the Catla catla treated with ZnO NPs. Journal of Biodiversity and Environmental Sciences 8(4), 91-104.

Asghar MS, Qureshi NA, Jabeen F, Khan MS, Shakeel M, Noureen A. 2015. Toxicity of zinc nanoparticles in fish: a critical review. Journal of Biodiversity and Environmental Sciences 7(1), 431-439.

Aung-Htut MT, Lam YT, Lim Y-L, Rinnerthaler M, Gelling CL, Yang H, Breitenbach M, Dawes IW. 2013. Maintenance of mitochondrial morphology by autophagy and its role in high glucose effects on chronological lifespan of Saccharomyces cerevisiae. Oxidative medicine and cellular longevity 2013. http://dx.doi.org/10.1155/2013/636287

Bae YS, Oh H, Rhee SG, Do Yoo Y. 2011. Regulation of reactive oxygen species generation in cell signaling. Molecules and cells 32(6), 491-509. http://dx.doi.org/10.1007/s10059-011-0276-3

Bailey DM, Davies B, Young IS, Jackson MJ, Davison GW, Isaacson R, Richardson RS. 2003. EPR spectroscopic detection of free radical outflow from an isolated muscle bed in exercising humans. Journal of applied physiology 94(5), 1714-1718. http://dx.doi.org/10.1152/japplphysiol.01024.2002

Bar-Or D, Thomas GW, Rael LT, Lau EP, Winkler JV. 2001. Asp-Ala-His-Lys (DAHK) inhibits copper-induced oxidative DNA double strand breaks and telomere shortening. Biochemical and biophysical research communications 282(1), 356-360. http://dx.doi.org/10.1006/bbrc.2001.4533

Belhadj Slimen I, Najar T, Ghram A, Dabbebi H, Ben Mrad M, Abdrabbah M. 2014. Reactive oxygen species, heat stress and oxidative-induced mitochondrial damage. A review. International journal of hyperthermia 30(7), 513-523. http://dx.doi.org/10.3109/02656736.2014.971446

Benham AM, van Lith M, Sitia R, Braakman I. 2013. Ero1–PDI interactions, the response to redox flux and the implications for disulfide bond formation in the mammalian endoplasmic reticulum. Philosophical Transactions of the Royal Society of London B: Biological Sciences 368(1617), 20110403. http://dx.doi.org/10.1098/rstb.2011.0403

Benov L. 2001. How superoxide radical damages the cell. Protoplasma 217(1-3), 33-36. http://dx.doi.org/10.1007/bf01289410

Beutler E. 2007. Iron storage disease: facts, fiction and progress. Blood Cells, Molecules, and Diseases 39(2), 140-147. http://dx.doi.org/10.1016/j.bcmd.2007.03.009

Bhandary B, Marahatta A, Kim H-R, Chae H-J. 2012. An involvement of oxidative stress in endoplasmic reticulum stress and its associated diseases. International journal of molecular sciences 14(1), 434-456. http://dx.doi.org/10.3390/ijms14010434

Binion DG, Rafiee P, Ramanujam KS, Fu S, Fisher PJ, Rivera MT, Johnson CP, Otterson MF, Telford GL, Wilson KT. 2000. Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion. Free Radical Biology and Medicine 29(9), 881-888. http://dx.doi.org/10.1016/s0891-5849(00)00391-9

Bonner JC. 2007. Lung fibrotic responses to particle exposure. Toxicologic pathology 35(1), 148-153. http://dx.doi.org/10.1080/01926230601060009

Bonomini F, Rodella LF, Rezzani R. 2015. Metabolic syndrome, aging and involvement of oxidative stress. Aging and disease 6(2), 109. http://dx.doi.org/10.14336/ad.2014.0305

Brandolini V, Tedeschi P, Capece A, Maietti A, Mazzotta D, Salzano G, Paparella A, Romano P. 2002. Saccharomyces cerevisiae wine strains differing in copper resistance exhibit different capability to reduce copper content in wine. World Journal of Microbiology and Biotechnology 18(6), 499-503.

Brash D, Ziegler A, Jonason A, Simon J, Kunala S, Leffell D. 1996. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. Paper presented at the The journal of investigative dermatology. Symposium proceedings/the Society for Investigative Dermatology, Inc.[and] European Society for Dermatological Research.

Breitenbach M, Rinnerthaler M, Hartl J, Stincone A, Vowinckel J, Breitenbach-Koller H, Ralser M. 2014. Mitochondria in ageing: there is metabolism beyond the ROS. FEMS yeast research 14(1), 198-212. http://dx.doi.org/10.1111/1567-1364.12134

Bretón RR, Rodríguez JCG. 2012. Excitotoxicity and oxidative stress in acute ischemic stroke. Stroke 8, 9. http://dx.doi.org/10.5772/28300

Brewer GJ. 2007. Iron and copper toxicity in diseases of aging, particularly atherosclerosis and Alzheimer’s disease. Experimental Biology and Medicine 232(2), 323-335.

Buzea C, Pacheco II, Robbie K. 2007. Nanomaterials and nanoparticles: sources and toxicity. Biointerphases 2(4), MR17-MR71. http://dx.doi.org/10.1116/1.2815690

Bylund J, Brown KL, Movitz C, Dahlgren C, Karlsson A. 2010. Intracellular generation of superoxide by the phagocyte NADPH oxidase: how, where, and what for? Free Radical Biology and Medicine 49(12), 1834-1845. http://dx.doi.org/10.1016/j.freeradbiomed.2010.09.016

Caldecott KW. 2008. Single-strand break repair and genetic disease. Nature Reviews Genetics 9(8), 619-631.

Cantu-Medellin N, Kelley EE. 2013. Xanthine oxidoreductase-catalyzed reactive species generation: A process in critical need of reevaluation. Redox biology 1(1), 353-358. http://dx.doi.org/10.1016/j.redox.2013.05.002

Catalá A. 2009. Lipid peroxidation of membrane phospholipids generates hydroxy-alkenals and oxidized phospholipids active in physiological and/or pathological conditions. Chemistry and physics of lipids 157(1), 1-11. http://dx.doi.org/10.1016/j.chemphyslip.2008.09.004

Chemizmu K, Fentona R. 2009. Fenton reaction-controversy concerning the chemistry. Ecological chemistry and engineering 16, 347-358.

Chen W, Balakrishnan K, Kuang Y, Han Y, Fu M, Gandhi V, Peng X. 2014. Reactive oxygen species (ROS) inducible DNA cross-linking agents and their effect on cancer cells and normal lymphocytes. Journal of medicinal chemistry 57(11), 4498-4510. http://dx.doi.org/10.1021/jm401349g

Chung HS, Wang S-B, Venkatraman V, Murray CI, Van Eyk JE. 2013. Cysteine oxidative posttranslational modifications emerging regulation in the cardiovascular system. Circulation research 112(2), 382-392. http://dx.doi.org/10.1161/circresaha.112.268680

Collin B, Busseuil D, Zeller M, Perrin C, Barthez O, Duvillard L, Vergely C, Bardou M, Dumas M, Cottin Y. 2007. Increased superoxide anion production is associated with early atherosclerosis and cardiovascular dysfunctions in a rabbit model. Molecular and cellular biochemistry 294(1-2), 225-235. http://dx.doi.org/10.1007/s11010-006-9263-y

Csányi G, Miller JFJ. 2014. Oxidative stress in cardiovascular disease. International journal of molecular sciences 15(4), 6002-6008. http://dx.doi.org/10.3390/ijms15046002

Datta R, Alfonso-García A, Cinco R, Gratton E. 2015. Fluorescence lifetime imaging of endogenous biomarker of oxidative stress. Scientific reports 5. http://dx.doi.org/10.1038/srep09848

Davies MJ, Fu S, Wang H, Dean RT. 1999. Stable markers of oxidant damage to proteins and their application in the study of human disease. Free Radical Biology and Medicine 27(11), 1151-1163. http://dx.doi.org/10.1016/b978-0-444-50957 4.50007-7

de Gruijl FR, van Kranen HJ, Mullenders LH. 2001. UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer. Journal of Photochemistry and Photobiology B: Biology 63(1), 19-27. http://dx.doi.org/10.1016/s1011-1344(01)00199-3

Dröse S, Brandt U. 2012. Molecular mechanisms of superoxide production by the mitochondrial respiratory chain Mitochondrial Oxidative Phosphorylation 145-169 p, Springer.

Fang J, Sawa T, Akaike T, Maeda H. 2002. Tumor-targeted delivery of polyethylene glycol-conjugated D-amino acid oxidase for antitumor therapy via enzymatic generation of hydrogen peroxide. Cancer research 62(11), 3138-3143. http://dx.doi.org/10.1002/ijc.22982

Farage M, Miller K, Elsner P, Maibach H. 2008. Intrinsic and extrinsic factors in skin ageing: a review. International Journal of Cosmetic Science 30(2), 87-95. http://dx.doi.org/10.1111/j.1468-2494.2007.00415.x

Finkel T. 2011. Signal transduction by reactive oxygen species. The Journal of cell biology 194(1), 7-15. http://dx.doi.org/10.1083/jcb.201102095

Foote CS, Valentine J, Greenberg A, Liebman JF. 2012. Active oxygen in chemistry 2, Springer Science & Business Media.

Fransen M, Nordgren M, Wang B, Apanasets O. 2012. Role of peroxisomes in ROS/RNS-metabolism: implications for human disease. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1822(9), 1363-1373. http://dx.doi.org/10.1016/j.bbadis.2011.12.001

Fruehauf JP, Trapp V. 2008. Reactive oxygen species: an Achilles’ heel of melanoma? Expert review of anticancer therapy 8(11), 1751-1757. http://dx.doi.org/10.1586/14737140.8.11.1751

Fubini B, Hubbard A. 2003. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis. Free Radical Biology and Medicine 34(12), 1507-1516. http://dx.doi.org/10.1016/s0891-5849(03)00149-7

Fujita K, Nishizawa H, Funahashi T, Shimomura I, Shimabukuro M. 2006. Systemic oxidative stress is associated with visceral fat accumulation and the metabolic syndrome. Circulation Journal 70(11), 1437-1442. http://dx.doi.org/10.1253/circj.70.1437

Gabbita SP, Lovell MA, Markesbery WR. 1998. Increased nuclear DNA oxidation in the brain in Alzheimer’s disease. Journal of neurochemistry 71(5), 2034-2040. http://dx.doi.org/10.1046/j.14714159.1998.71052034.x

Ghafourifar P, Cadenas E. 2005. Mitochondrial nitric oxide synthase. Trends in Pharmacological Sciences 26(4), 190-195. http://dx.doi.org/10.1016/j.tips.2005.02.005

Goetz ME, Luch A. 2008. Reactive species: a cell damaging rout assisting to chemical carcinogens. Cancer letters 266(1), 73-83. http://dx.doi.org/10.1016/j.canlet.2008.02.035

Gupta RK, Patel AK, Shah N, Chaudhary A, Jha UK, Yadav UC, Gupta PK, Pakuwal U. 2013. Oxidative stress and antioxidants in disease and cancer: a review. Asian Pacific journal of cancer prevention: APJCP 15(11), 4405-4409. http://dx.doi.org/10.7314/apjcp.2014.15.11.4405

Gupte A, Mumper RJ. 2007. Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells. Free Radical Biology and Medicine 43(9), 1271-1278. http://dx.doi.org/10.1016/j.freeradbiomed.2007.07.003

Haber F, Weiss J. (1934). The catalytic decomposition of hydrogen peroxide by iron salts. Paper presented at the Proceedings of the Royal Society of London A: Mathematical, Physical and Engineering Sciences.

Halliwell B, Gutteridge JM. 2015. Free radicals  in biology and medicine: Oxford University Press, USA.

Hamid A, Khan MU, Yaqoob J, Umar A, Ali A, Rehman A, Javed S, Adnan S, Anwar A, Khan MS. 2016. Assessment of mercury load in river Ravi, urban sewage streams of Lahore Pakistan and its impact on the oxidative stress of exposed fish. Journal of Biodiversity and Environmental Sciences 8(4), 63-72.

Harman D. 1955. Aging: a theory based on free radical and radiation chemistry. http://dx.doi.org/10.1093/geronj/11.3.298

Harman D. 1972. The biologic clock: the mitochondria? Journal of the American Geriatrics Society 20(4), 145-147. http://dx.doi.org/10.1111/j.1532-5415.1972.tb00787.x

Hekimi S, Lapointe J, Wen Y. 2011. Taking a “good” look at free radicals in the aging process. Trends in cell biology 21(10), 569-576. http://dx.doi.org/10.1016/j.tcb.2011.06.008

Huang Y-W, Wu C-h, Aronstam RS. 2010. Toxicity of transition metal oxide nanoparticles: recent insights from in vitro studies. Materials 3(10), 4842-4859. http://dx.doi.org/10.3390/ma3104842

Inoue M, Sato EF, Nishikawa M, Park A-M, Kira Y, Imada I, Utsumi K. 2003. Mitochondrial generation of reactive oxygen species and its role in aerobic life. Current medicinal chemistry 10(23), 2495-2505. http://dx.doi.org/10.2174/0929867033456477

Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J-I. 2008. ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis. Science 320(5876), 661-664. http://dx.doi.org/10.1126/science.1156906

Jomova K, Valko M. 2011. Advances in metal-induced oxidative stress and human disease. Toxicology 283(2), 65-87. http://dx.doi.org/10.1016/j.tox.2011.03.001

Jones DP. 2006. Redefining oxidative stress. Antioxidants & redox signaling 8(9-10), 1865-1879. http://dx.doi.org/10.1089/ars.2006.8.1865

Juarranz Á, Jaén P, Sanz-Rodríguez F, Cuevas J, González S. 2008. Photodynamic therapy of cancer. Basic principles and applications. Clinical and Translational Oncology 10(3), 148-154. http://dx.doi.org/10.1007/s12094-008-0172-2

Judge S, Leeuwenburgh C. 2007. Cardiac mitochondrial bioenergetics, oxidative stress, and aging. American Journal of Physiology-Cell Physiology 292(6), C1983-C1992. http://dx.doi.org/10.1152/ajpcell.00285.2006

Kadhim M, Salomaa S, Wright E, Hildebrandt G, Belyakov OV, Prise KM, Little MP. 2013. Non-targeted effects of ionising radiation—Implications for low dose risk. Mutation Research/Reviews in Mutation Research 752(2), 84-98. http://dx.doi.org/10.1016/j.mrrev.2012.12.001

Kaiser J, Heidenreich W, Monchaux G, Morlier J, Collier C. 2004. Lung tumour risk in radon-exposed rats from different experiments: comparative analysis with biologically based models. Radiation and environmental biophysics 43(3), 189-201. http://dx.doi.org/10.1007/s00411-004-0251-x

Kareyeva AV, Grivennikova VG, Vinogradov AD. 2012. Mitochondrial hydrogen peroxide production as determined by the pyridine nucleotide pool and its redox state. Biochimica et Biophysica Acta (BBA)-Bioenergetics 1817(10), 1879-1885. http://dx.doi.org/10.1016/j.bbabio.2012.03.033

Kataria N, Kataria AK, Pandey N, Gupta P. 2010. Serum biomarkers of physiological defense against reactive oxygen species during environmental stress in Indian dromedaries. HVM Bioflux 2(2), 55-60.

Khan M, Quershi N, Jabeen F, Asghar M, Shakeel M. 2016. Analysis of minerals profile, phenolic compounds and potential of Garlic (Allium sativum) as antioxidant scavenging the free radicals. International Journal of Biosciences 8(4), 72-82. http://dx.doi.org/10.12692/ijb/8.4.72-82

Khan MS, Jabeen F, Asghar MS, Qureshi NA, Shakeel M, Noureen A, Shabbir S. 2015. Role of nao-ceria in the amelioration of oxidative stress: current and future applications in medicine. International Journal of Biosciences 6(8), 89-109. http://dx.doi.org/10.12692/ijb/6.8.89-109

Khan MS, Jabeen F, Qureshi NA, Asghar MSSM, Noureen A. 2015b. Toxicity of silver nanoparticles in fish: a critical review. Journal of Biodiversity and Environmental Sciences 6(5), 211-227.

Kizhakekuttu TJ, Widlansky ME. 2010. Natural antioxidants and hypertension: promise and challenges. Cardiovascular therapeutics 28(4), e20-e32. http://dx.doi.org/10.1111/j.1755-5922.2010.00137.x

Klaunig JE, Kamendulis LM. 2004. The role of oxidative stress in carcinogenesis. Annu. Rev. Pharmacol. Toxicol. 44, 239-267. http://dx.doi.org/10.1201/9780203904787.ch4

Klaunig JE, Kamendulis LM, Hocevar BA. 2010. Oxidative stress and oxidative damage in carcinogenesis. Toxicologic pathology 38(1), 96-109.

Knaapen AM, Borm PJ, Albrecht C, Schins RP. 2004. Inhaled particles and lung cancer. Part A: Mechanisms. International Journal of Cancer 109(6), 799-809. http://dx.doi.org/10.1002/ijc.11708

Kontoghiorghes GJ, Efstathiou A, Ioannou-Loucaides S, Kolnagou A. 2008. Chelators controlling metal metabolism and toxicity pathways: applications in cancer prevention, diagnosis and treatment. Hemoglobin 32(1-2), 217-227. http://dx.doi.org/10.1080/03630260701727119

Kowald A, Lehrach H, Klipp E. 2006. Alternative pathways as mechanism for the negative effects associated with overexpression of superoxide dismutase. Journal of theoretical biology 238(4), 828-840. http://dx.doi.org/10.1016/j.jtbi.2005.06.034

Kruidenier L, Kuiper I, Lamers CB, Verspaget HW. 2003. Intestinal oxidative damage in inflammatory bowel disease: semi‐quantification, localization, and association with mucosal antioxidants. The Journal of pathology 201(1), 28-36. http://dx.doi.org/10.1002/path.1409

Krumova K, Cosa G. 2016. Overview of Reactive Oxygen Species. http://dx.doi.org/10.1039/9781849737722-00279

Kukreja R, Kontos H, Hess M, Ellis E. 1986. Superoxide generation by prostaglandin synthetase and lipoxygenase in presence of NADH or NADPH. Paper presented at the FEDERATION PROCEEDINGS.

Kumar B, Koul S, Khandrika L, Meacham RB, Koul HK. 2008. Oxidative stress is inherent in prostate cancer cells and is required for aggressive phenotype. Cancer research 68(6), 1777-1785. http://dx.doi.org/10.1158/0008-5472.can-07-5259

Kuppusamy P, Zweier JL. 1989. Characterization of free radical generation by xanthine oxidase. Evidence for hydroxyl radical generation. Journal of Biological Chemistry 264(17), 9880-9884. http://dx.doi.org/10.1080/1071576031000107344

Leone N, Courbon D, Ducimetiere P, Zureik M. 2006. Zinc, copper, and magnesium and risks for all-cause, cancer, and cardiovascular mortality. Epidemiology 17(3), 308-314. http://dx.doi.org/10.1097/01.ede.0000209454.41466.b7

Letavayová L, Vlčková V, Brozmanová J. 2006. Selenium: from cancer prevention to DNA damage. Toxicology 227(1), 1-14. http://dx.doi.org/10.1016/j.tox.2006.07.017

Linke A, Adams V, Schulze PC, Erbs S, Gielen S, Fiehn E, Möbius-Winkler S, Schubert A, Schuler G, Hambrecht R. 2005. Antioxidative effects of exercise training in patients with chronic heart failure increase in radical scavenger enzyme activity in skeletal muscle. Circulation 111(14), 1763-1770.

Little M, Heidenreich W, Moolgavkar S, Schöllnberger H, Thomas D. 2008. Systems biological and mechanistic modelling of radiation-induced cancer. Radiation and environmental biophysics 47(1), 39-47. http://dx.doi.org/10.1007/s00411-007-0150-z

Lugogo NL, Bappanad D, Kraft M. 2011. Obesity, metabolic dysregulation and oxidative stress in asthma. Biochimica et Biophysica Acta (BBA)-General Subjects 1810(11), 1120-1126. http://dx.doi.org/10.1016/j.bbagen.2011.09.004

Luis A. 2011. Peroxisomes as a cellular source of reactive nitrogen species signal molecules. Archives of Biochemistry and Biophysics 506(1), 1-11. http://dx.doi.org/10.1016/j.abb.2010.10.022

Matheson PJ, Wilson MA, Garrison RN. 2000. Regulation of intestinal blood flow. Journal of Surgical Research 93(1), 182-196. http://dx.doi.org/10.1006/jsre.2000.5862

Memısoğullari R, Taysı S, Bakan E, Capoglu I. 2003. Antioxidant status and lipid peroxidation in type II diabetes mellitus. Cell biochemistry and function 21(3), 291-296. http://dx.doi.org/10.1002/cbf.1025

Mishra OP, Pooniya V, Ali Z, Upadhyay RS, Prasad R. 2008. Antioxidant status of children with acute renal failure. Pediatric Nephrology 23(11), 2047-2051. http://dx.doi.org/10.1007/s00467-008-0875-1

Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. 2007. Trends in oxidative aging theories. Free Radical Biology and Medicine 43(4), 477-503. http://dx.doi.org/10.1016/j.freeradbiomed.2007.03.034

Murphy MP. 2009. How mitochondria produce reactive oxygen species. Biochemical Journal 417(1), 1-13. http://dx.doi.org/10.1042/bj20081386

Nakabeppu Y. 2014. Cellular levels of 8-oxoguanine in either DNA or the nucleotide pool play pivotal roles in carcinogenesis and survival of cancer cells. International journal of molecular sciences 15(7), 12543-12557. http://dx.doi.org/10.3390/ijms150712543

Nayak D, Karmen C, Frishman W, Vakili B. 2000. Antioxidant vitamins and enzymatic and synthetic oxygen-derived free radical scavengers in the prevention and treatment of cardiovascular disease. Heart disease (Hagerstown, Md.) 3(1), 28-45. http://dx.doi.org/10.1097/00132580-200101000-00006

Nel A, Xia T, Mädler L, Li N. 2006. Toxic potential of materials at the nanolevel. Science 311(5761), 622-627.

Nishiyama Y, Allakhverdiev SI, Murata N. 2011. Protein synthesis is the primary target of reactive oxygen species in the photoinhibition of photosystem II. Physiologia Plantarum 142(1), 35-46. http://dx.doi.org/10.1111/j.1399-3054.2011.01457.x

Oyinloye BE, Adenowo AF, Kappo AP. 2015. Reactive Oxygen Species, Apoptosis, Antimicrobial Peptides and Human Inflammatory Diseases. Pharmaceuticals 8(2), 151-175.

Pandey KB, Rizvi SI. 2009. Plant polyphenols as dietary antioxidants in human health and disease. Oxidative medicine and cellular longevity 2(5), 270-278. http://dx.doi.org/10.4161/oxim.2.5.9498

Pappolla M, Omar R, Kim K, Robakis N. 1992. Immunohistochemical evidence of oxidative [corrected] stress in Alzheimer’s disease. The American journal of pathology 140(3), 621.

Park JS, Svetkauskaite D, He Q, Kim J-Y, Strassheim D, Ishizaka A, Abraham E. 2004. Involvement of toll-like receptors 2 and 4 in cellular activation by high mobility group box 1 protein. Journal of Biological Chemistry 279(9), 7370-7377. http://dx.doi.org/10.1074/jbc.m306793200

Park S, Imlay JA. 2003. High levels of intracellular cysteine promote oxidative DNA damage by driving the Fenton reaction. Journal of bacteriology 185(6), 1942-1950. http://dx.doi.org/10.1128/jb.185.6.1942-1950.2003

Piantadosi CA, Zhang J. 1996. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 27(2), 327-332. http://dx.doi.org/10.1161/01.str.27.2.327

Plaetzer K, Krammer B, Berlanda J, Berr F, Kiesslich T. 2009. Photophysics and photochemistry of photodynamic therapy: fundamental aspects. Lasers in medical science 24(2), 259-268. http://dx.doi.org/10.1007/s10103-008-0539-1

Poljšak B, Dahmane R. 2012. Free radicals and extrinsic skin aging. Dermatology research and practice 2012. http://dx.doi.org/10.1155/2012/135206

Prokai L, Yan LJ, VeraSerrano JL, Stevens SM, Forster MJ. 2007. Mass spectrometry‐based survey of age‐associated protein carbonylation in rat brain mitochondria. Journal of mass spectrometry 42(12), 1583-1589. http://dx.doi.org/10.1002/jms.1345

Pu X, Kamendulis LM, Klaunig JE. 2006. Acrylonitrile‐induced oxidative DNA damage in rat astrocytes. Environmental and molecular mutagenesis 47(8), 631-638. http://dx.doi.org/10.1002/em.20249

Que EL, Domaille DW, Chang CJ. 2008. Metals in neurobiology: probing their chemistry and biology with molecular imaging. Chemical Reviews 108(5), 1517-1549. http://dx.doi.org/10.1002/chin.200833267

Rao R, Møller IM. 2011. Pattern of occurrence and occupancy of carbonylation sites in proteins. Proteomics 11(21), 4166-4173. http://dx.doi.org/10.1002/pmic.201100223

Riley P. 1994. Free radicals in biology: oxidative stress and the effects of ionizing radiation. International journal of radiation biology 65(1), 27-33. http://dx.doi.org/10.1080/09553009414550041

Rinnerthaler M, Büttner S, Laun P, Heeren G, Felder TK, Klinger H, Weinberger M, Stolze K, Grousl T, Hasek J. 2012. Yno1p/Aim14p, a NADPH-oxidase ortholog, controls extramitochondrial reactive oxygen species generation, apoptosis, and actin cable formation in yeast. Proceedings of the National Academy of Sciences 109(22), 8658-8663. http://dx.doi.org/10.1073/pnas.1201629109

Risom L, Møller P, Loft S. 2005. Oxidative stress-induced DNA damage by particulate air pollution. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 592(1), 119-137. http://dx.doi.org/10.1016/j.mrfmmm.2005.06.012

Roberts CK, Sindhu KK. 2009. Oxidative stress and metabolic syndrome. Life sciences 84(21), 705-712. http://dx.doi.org/10.1016/j.lfs.2009.02.026

Sanders LM, Henderson CE, Hong MY, Barhoumi R, Burghardt RC, Carroll RJ, Turner ND, Chapkin RS, Lupton JR. 2004. Pro-oxidant environment of the colon compared to the small intestine may contribute to greater cancer susceptibility. Cancer letters 208(2), 155-161. http://dx.doi.org/10.1016/j.canlet.2003.12.007

Sauvaigo S, Caillat S, Odin F, Nkengne A, Bertin C, Oddos T. 2010. Effect of aging on DNA excision/synthesis repair capacities of human skin fibroblasts. Journal of Investigative Dermatology 130(6), 1739-1741. http://dx.doi.org/10.1038/jid.2010.10

Savini I, Catani MV, Evangelista D, Gasperi V, Avigliano L. 2013. Obesity-associated oxidative stress: strategies finalized to improve redox state. International journal of molecular sciences 14(5), 10497-10538. http://dx.doi.org/10.3390/ijms140510497

Schins RP. 2002. Mechanisms of genotoxicity of particles and fibers. Inhalation toxicology 14(1), 57-78. http://dx.doi.org/10.1080/089583701753338631

Selley M, Close D, Stern S. 2002. The effect of increased concentrations of homocysteine on the concentration of (E)-4-hydroxy-2-nonenal in the plasma and cerebrospinal fluid of patients with Alzheimer’s disease. Neurobiology of aging 23(3), 383-388. http://dx.doi.org/10.1016/s0197-4580(01)00327-x

Shafaq N. 2012. An overview of oxidative stress and antioxidant defensive system. http://dx.doi.org/10.4172/scientificreports.413

Shaheen M, Echeverry D, Oblad MG, Montoya MI, Teklehaimanot S, Akhtar AJ. 2007. Hepatitis C, metabolic syndrome, and inflammatory markers: results from the Third National Health and Nutrition Examination Survey [NHANES III]. Diabetes research and clinical practice 75(3), 320-326. http://dx.doi.org/10.1016/j.diabres.2006.07.008

Shakeel M, Jabeen F, Shabbir S, Asghar MS, Khan MS, Chaudhry AS. 2015. Toxicity of Nano-Titanium Dioxide (TiO2-NP) Through Various Routes of Exposure: a Review. Biological trace element research, 1-36. http://dx.doi.org/10.1007/s12011-015-0550-x

Shen H, Anastasio C. 2012. A comparison of hydroxyl radical and hydrogen peroxide generation in ambient particle extracts and laboratory metal solutions. Atmospheric environment 46, 665-668. http://dx.doi.org/10.1016/j.atmosenv.2011.10.006

Sies H. 1997. Oxidative stress: oxidants and antioxidants. Experimental physiology 82(2), 291-295.

Singh R, Devi S, Gollen R. 2015. Role of free radical in atherosclerosis, diabetes and dyslipidaemia: larger‐than‐life. Diabetes/metabolism research and reviews 31(2), 113-126. http://dx.doi.org/10.1002/dmrr.2558

Sosa V, Moliné T, Somoza R, Paciucci R, Kondoh H, LLeonart ME. 2013. Oxidative stress and cancer: an overview. Ageing research reviews 12(1), 376-390.

Stadtman E. 1995. The status of oxidatively modified proteins as a marker of aging. LIFE SCIENCES RESEARCH REPORTS, 129-129. http://dx.doi.org/10.1016/s0891-5849(02)00764-5

Steffes MW, Gross MD, Lee DH, Schreiner PJ, Jacobs DR. 2006. Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Obesity 14(2), 319-326. http://dx.doi.org/10.1038/oby.2006.41

Steinberg D. 1997. Low density lipoprotein oxidation and its pathobiological significance. Journal of Biological Chemistry 272(34), 20963-20966. http://dx.doi.org/10.1074/jbc.272.34.20963

Stuehr D, Pou S, Rosen GM. 2001. Oxygen reduction by nitric-oxide synthases. Journal of Biological Chemistry 276(18), 14533-14536. http://dx.doi.org/10.1074/jbc.r100011200

Tamai M, Furuta H, Kawashima H, Doi A, Hamanishi T, Shimomura H, Sakagashira S, Nishi M, Sasaki H, Sanke T. 2006. Extracellular superoxide dismutase gene polymorphism is associated with insulin resistance and the susceptibility to type 2 diabetes. Diabetes research and clinical practice 71(2), 140-145. http://dx.doi.org/10.1016/j.diabres.2005.05.006

te Velde AA, Pronk I, de Kort F, Stokkers PC. 2008. Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2? European journal of gastroenterology & hepatology 20(6), 555-560. http://dx.doi.org/10.1097/meg.0b013e3282f45751

Tribble DL, Committee N. 1999. Antioxidant Consumption and Risk of Coronary Heart Disease: Emphasis on Vitamin C, Vitamin E, and β-Carotene A Statement for Healthcare Professionals From the American Heart Association. Circulation 99(4), 591-595. http://dx.doi.org/10.1161/01.cir.99.4.591

Tulard A, Hoffschir F, de Boisferon FH, Luccioni C, Bravard A. 2003. Persistent oxidative stress after ionizing radiation is involved in inherited radiosensitivity. Free Radical Biology and Medicine 35(1), 68-77. http://dx.doi.org/10.1016/s0891-5849(03)00243-0

Valko M, Rhodes C, Moncol J, Izakovic M, Mazur M. 2006. Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chemico-biological interactions 160(1), 1-40. http://dx.doi.org/10.1016/j.cbi.2005.12.009

Vincent HK, Bourguignon CM, Taylor AG. 2010. Relationship of the dietary phytochemical index to weight gain, oxidative stress and inflammation in overweight young adults. Journal of human nutrition and dietetics 23(1), 20-29. http://dx.doi.org/10.1111/j.1365-277x.2009.00987.x

Wang M, Sun S, Neufeld CI, PerezRamirez B, Xu Q. 2014. Reactive Oxygen Species‐Responsive Protein Modification and Its Intracellular Delivery for Targeted Cancer Therapy. Angewandte Chemie 126(49), 13662-13666. http://dx.doi.org/10.1002/ange.201407234

Waris G, Ahsan H. 2006. Reactive oxygen species: role in the development of cancer and various chronic conditions. Journal of carcinogenesis 5(1), 14.

Wellen KE, Hotamisligil GS. 2005. Inflammation, stress, and diabetes. The Journal of clinical investigation 115(5), 1111-1119. http://dx.doi.org/10.1172/jci25102

WheatleyPrice P, Asomaning K, Reid A, Zhai R, Su L, Zhou W, Zhu A, Ryan DP, Christiani DC, Liu G. 2008. Myeloperoxidase and superoxide dismutase polymorphisms are associated with an increased risk of developing pancreatic adenocarcinoma. Cancer 112(5), 1037-1042. http://dx.doi.org/10.1002/cncr.23267

Wheeler MD, Nakagami M, Bradford BU, Uesugi T, Mason RP, Connor HD, Dikalova A, Kadiiska M, Thurman RG. 2001. Overexpression of manganese superoxide dismutase prevents alcohol-induced liver injury in the rat. Journal of Biological Chemistry 276(39), 36664-36672. http://dx.doi.org/10.1074/jbc.m105352200

Whicher J, Evans SW. 2012. Biochemistry of inflammation 18, Springer Science & Business Media.

Wickens AP. 2001. Ageing and the free radical theory. Respiration physiology 128(3), 379-391. http://dx.doi.org/10.1016/s0034-5687(01)00313-9

Wilson MR, Lightbody JH, Donaldson K, Sales J, Stone V. 2002. Interactions between ultrafine particles and transition metals in vivo and in vitro. Toxicology and applied pharmacology 184(3), 172-179. http://dx.doi.org/10.1006/taap.2002.9501

Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR, Nel AE. 2006. Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. Nano letters 6(8), 1794-1807. http://dx.doi.org/10.1021/nl061025k

Ya Sklyarov A, Panasyuk N, Fomenko I. 2011. Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in development of experimental ulcerative colitis. Journal of Physiology and Pharmacology 62(1), 65. http://dx.doi.org/10.7124/bc.00008e

Yang H, Jin X, Lam K, Wai C, Yan S-K. 2011. Oxidative stress and diabetes mellitus. Clinical Chemistry and Laboratory Medicine 49(11), 1773-1782.

Young I, Woodside J. 2001. Antioxidants in health and disease. Journal of clinical pathology 54(3), 176-186.

Zappasodi F, Salustri C, Babiloni C, Cassetta E, Del Percio C, Ercolani M, Rossini PM, Squitti R. 2008. An observational study on the influence of the APOE-ε4 allele on the correlation between ‘free’copper toxicosis and EEG activity in Alzheimer disease. Brain research 1215, 183-189. http://dx.doi.org/10.1016/j.brainres.2008.03.066

Zelko IN, Mariani TJ, Folz RJ. 2002. Superoxide dismutase multigene family: a comparison of the CuZn-SOD (SOD1), Mn-SOD (SOD2), and EC-SOD (SOD3) gene structures, evolution, and expression. Free Radical Biology and Medicine 33(3), 337-349. http://dx.doi.org/10.1016/s0891-5849(02)00905-x

Zhang Q, Zou P, Zhan H, Zhang M, Zhang L, Ge R-S, Huang Y. 2011. Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated Leydig cell damage. Toxicology letters 205(2), 183-189. http://dx.doi.org/10.1016/j.toxlet.2011.06.003

Zhao Y, Zhao B. 2013. Oxidative stress and the pathogenesis of Alzheimer’s disease. Oxidative medicine and cellular longevity 2013. http://dx.doi.org/10.1155/2013/316523

Zheng Y, Li X-K, Wang Y, Cai L. 2008. The role of zinc, copper and iron in the pathogenesis of diabetes and diabetic complications: therapeutic effects by chelators. Hemoglobin 32(1-2), 135-145. http://dx.doi.org/10.1080/03630260701727077

Zhou R, Yazdi AS, Menu P, Tschopp J. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature 469(7329), 221-225. http://dx.doi.org/10.1038/nature10156

Ziboh VA, Miller CC, Cho Y. 2000. Metabolism of polyunsaturated fatty acids by skin epidermal enzymes: generation of antiinflammatory and antiproliferative metabolites. The American journal of clinical nutrition 71(1), 361s-366s.