Hepatoprotective Property of Parameria laevigata Leaf Extracts in CCl4- hepatotoxicity Induced Sprague Dawley Rats
Paper Details
Hepatoprotective Property of Parameria laevigata Leaf Extracts in CCl4- hepatotoxicity Induced Sprague Dawley Rats
Abstract
This study investigated the hepatoprotective property of Parameria laevigata leaf extracts in CCl4- hepatotoxicity-induced Sprague Dawley rats. An experimental design consisting of four (4) treatments, positive control and negative control, was used in the study. It has two (2) major phases, namely: plant authentication and screening of secondary metabolites and enzymometric analysis (SGOT and SGPT) using a blood chemistry analyzer. Results of the study revealed that the leaf extract of Parameria laevigata exhibits hepatoprotective properties as evidenced by the SGPT and SGOT levels and that of the histopathological analysis when induced at 100% concentration. The results were comparable to that of the positive control. The hepatoprotective activity of the Parameria laevigata leaf extracts is attributed to the collective presence of secondary metabolites such as flavonoids, saponins, and tannins. Fractionation and isolation of the active secondary metabolite must therefore be carried out before advancing to the pre-clinical and clinical trials phases of experimentation.
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