Homeostasis model assessment of insulin resistance in response to aerobic program in adult obese women

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Research Paper 01/10/2013
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Homeostasis model assessment of insulin resistance in response to aerobic program in adult obese women

Zahedmanesh Forouzan, Pishkar Leila, Zahedmanesh Farnaz, Yousefi Soheila
Int. J. Biosci.3( 10), 306-311, October 2013.
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Abstract

Physical activity is widely accepted that improve glucose homeostasis and insulin resistance in obese patient populations. This study was aimed to investigate the effect of a long term aerobic training on glucose profile and insulin action in obese women. For this purpose, pre and post aerobic training (3 per week / 12 weeks) blood samples were collected in fifteen adult obese women and compared with control group (no training) matched for age, gender, height, and BMI. Student’s t-tests for paired samples were performed to determine whether there were significant within-group changes in the outcomes. A p-value less than 0.05 were considered statistically significant. At baseline there were no differences in the biochemical variables and anthropometrical parameters between the two groups. There was a decrease in fasting glucose levels and anthropometrical markers after exercise intervention. Compared to pre-training, serum insulin and insulin resistance decreased significantly after exercise program but not in the control group. Our results indicate that aerobic training for long time improves glucose homeostasis in obese men that is associated with improved insulin resistance.

VIEWS 8

Belkina AC, Denis GV. 2010. Obesity genes and insulin resistance. Current Opinion in Endocrinology, Diabetes and Obesity. 17(5), 472-7. http://dx.doi.org/10.1097/MED.0b013e32833c5c48

Berggren JR, Hulver MW, Houmard JA. 2005. Fat  as  an  endocrine  organ:  influence  of  exercise. Journal of Applied Physiology 99, 757–764. http://dx.doi.org/10.1152/japplphysiol.00134.2005

Brooks N, Layne JE, Gordon PL, Roubenoff R, Nelson ME, Castaneda-Sceppa C. 2007. Strength training improves muscle quality and insulin sensitivity in Hispanic older adults with type 2 diabetes. International Journal of Medical Sciences 4(1), 19–27. http://dx.doi.org/10.7150/ijms.4.19

Cockram CS. 2000. The epidemiology of diabetes mellitus in the Asia-Pacific region. Hong Kong Medical Journal 6, 43–52.

Corcoran  MP,  Lamon-Fava  S,  Fielding  RA. 2007. Skeletal muscle lipid deposition and insulin resistance: effect of dietary fatty acids and exercise. American Journal of Clinical Nutrition 85, 662–677.

DeFronzo RA, Bonadonna RC, Ferrannini E. 1992. Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15, 318–353. http://dx.doi.org/10.2337/diacare.15.3.318

Duncan M, Singh B, Wise P. 1995.  A  simple measure of insulin resistance. Lancet  346, 120–1. http://dx.doi.org/10.1016/S0140-6736(95)92143-5

Fain JN, Madan AK, Hiler ML, Cheema P, Bahouth SW. 2004. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology 145, 2273–2282. http://dx.doi.org/10.1210/en.2003-1336

Heled Y, Shapiro Y, Shani Y, Moran DS, Langzam L, Barash V, Sampson SR, Meyerovitch J. 2004. Physical exercise enhances hepatic insulin signaling and inhibits phosphoenolpyruvate carboxykinase activity in diabetes-prone Psammomys obesus. Metabolism 53, 836–841. http://dx.doi.org/10.1016/j.metabol.2004.02.001

Holloszy JO. 2005. Exercise-induced increase in muscle insulin sensitivity. Journal of Applied Physiology 99, 338–343. http://dx.doi.org/10.1152/japplphysiol.00123.2005

Imbeault P. 2007. Environmental influences on adiponectin levels in humans. Applied Physiology, Nutrition, and Metabolism 32(3), 505-11. http://dx.doi.org/10.1139/H07-017

Kaastra B, Manders RJ, Van Breda E, Kies A, Jeukendrup AE, Keizer HA, Kuipers H, Van Loon LJ. 2006. Effects of increasing insulin secretion on acute postexercise blood glucose disposal. Medicine Science and Sports Exercise 38, 268–275. http://dx.doi.org/10.1249/01.mss.0000183875.86476.bd

Kahn SE. 2001. The importance of β-cell failure in the development and progression of type 2 diabetes. Journal of Clinical Endocrinology & Metabolism 86, 4047–4058. http://dx.doi.org/10.1210/jc.86.9.4047

Lara-Castro C, Luo N, Wallace P, Klein RL, Garvey WT. 2006. Adiponectin multimeric complexes and the metabolic syndrome trait cluster. Diabetes 55(1), 249-259. http://dx.doi.org/10.2337/diabetes.55.01.06.db05-1105

Machado UF, Schaan BD, Seraphim PM. 2006. Transportadores de glicose na síndrome metabólica. Arquivos Brasileiros de Endocrinologia & Metabologia 50, 177-89. http://dx.doi.org/10.1590/S0004-27302006000200004

Manson JE, Nathan DM, Krolewski AS, Stampfer MJ, Willett WC, and Hennekens CH. 1992. A prospective study of exercise and incidence of diabetes among United States male physicians. Journal of the American Medical Association 268, 63–67. http://dx.doi.org/10.1001/jama.268.1.63

Park S, Hong SM, Lee JE, Sung SR. 2007. Exercise improves glucose homeostasis that has been impaired by a high-fat diet by potentiating pancreatic B- cell function and mass through IRS2 in diabetic rats. Journal of Applied Physiology 103(5),1764-71. http://dx.doi.org/10.1152/japplphysiol.00434.2007

Perseghin G, Lattuada G, De Cobelli F, Ragogna F, Ntali G, Esposito A, Belloni E, Canu T, Terruzzi I, Scifo P, Del Maschio A, Luzi L. 2007. Habitual physical activity is associated with intrahepatic fat content in humans. Diabetes Care 30, 683–688. http://dx.doi.org/10.2337/dc06-2032

Sheu WH, Chang TM, Lee WJ, Ou HC, Wu CM, Tseng LN ET AL. 2008. Effect of weight loss on proinflammatory state of mononuclear cells in obese women. Obesity (Silver Spring) 16(5), 1033-8. http://dx.doi.org/10.1038/oby.2008.37

Shulman GI. 2000. Cellular mechanisms of insulin resistance. Journal of Clinical Investigation 106, 171-6. http://dx.doi.org/10.1172/JCI10583

Tang Z, Yuan L, Gu C, Liu Y, Zhu L. 2005. Effect of exercise on the expression of adiponectin mRNA and GLUT4 mRNA in type 2 diabetic rats. Journal of Huazhong University of Science and Technology. Medical sciences 25(2), 191-3. http://dx.doi.org/10.1007/BF02873574

Urano Y, Sakurai T, Ueda H, Ogasawara J, Sakurai T, Takei M, Izawa T. 2004. Desensitization of the inhibitory effect of norepinephrine on insulin secretion from pancreatic islets of exercise-trained rats. Metabolism 53, 1424–1432. http://dx.doi.org/10.1016/j.metabol.2004.06.008

Wei M, Gibbons LW, Mitchell TL, Kampert JB, Lee CD, and Blair SN. 1999. The association between cardiorespiratory fitness and impaired fasting glucose and type 2 diabetes mellitus in men. Annals of Internal Medicine 130, 89–96. http://dx.doi.org/10.7326/0003-4819-130-2-199901190-00002

Wellen KE, Hotamisligil GS. 2005. Inflammation, stress, and diabetes. Journal of Clinical Investigation 115, 1111–1119. http://dx.doi.org/10.1172/JCI25102